SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4arc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 5 GLU A 136
TYR A 133
TYR A 132
PRO A 431
 None
 1.38A 1dfoB-4arcA:
undetectable		 1dfoB-4arcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 5 GLU A 136
TYR A 133
TYR A 132
PRO A 431
 None
 1.38A 1dfoA-4arcA:
undetectable		 1dfoA-4arcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 5 GLU A 136
TYR A 133
TYR A 132
PRO A 431
 None
 1.38A 1dfoD-4arcA:
undetectable		 1dfoD-4arcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 5 GLU A 136
TYR A 133
TYR A 132
PRO A 431
 None
 1.39A 1dfoC-4arcA:
undetectable		 1dfoC-4arcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		6 / 12 GLY A  51
ASN A  55
SER A 496
GLY A 530
VAL A 569
MET A 620
 None
None
LEU  A1001 ( 3.7A)
None
None
None
 0.80A 1ffyA-4arcA:
27.6		 1ffyA-4arcA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 ARG A 643
GLY A 118
ASP A  60
TRP A  18
 None
 1.07A 1kf6M-4arcA:
undetectable
1kf6N-4arcA:
undetectable		 1kf6M-4arcA:
22.78
1kf6N-4arcA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		3 / 3 ALA A 323
VAL A 303
TRP A 321
 None
 0.87A 1nt5A-4arcA:
undetectable		 1nt5A-4arcA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		3 / 3 ALA A 323
VAL A 303
TRP A 321
 None
 0.87A 1nt5B-4arcA:
undetectable		 1nt5B-4arcA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		6 / 12 GLY A  51
HIS A  52
SER A 496
GLY A 530
VAL A 569
MET A 620
 None
None
LEU  A1001 ( 3.7A)
None
None
None
 0.77A 1qu2A-4arcA:
27.6		 1qu2A-4arcA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 12 GLY A  51
HIS A  52
ASN A  55
SER A 496
VAL A 569
 None
None
None
LEU  A1001 ( 3.7A)
None
 0.47A 1qu3A-4arcA:
32.0		 1qu3A-4arcA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 8 TRP A 191
GLU A 486
MET A 434
VAL A 452
 None
 1.12A 1rs6A-4arcA:
undetectable
1rs6B-4arcA:
2.6		 1rs6A-4arcA:
18.53
1rs6B-4arcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 11 ARG A 759
GLN A 751
ASP A 791
HIS A 706
ARG A 702
 None
 1.25A 2a68M-4arcA:
0.0		 2a68M-4arcA:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		8 / 8 MET A  40
TYR A  43
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.67A 2bteA-4arcA:
34.7		 2bteA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		8 / 8 MET A  40
TYR A  43
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.63A 2bteD-4arcA:
34.1		 2bteD-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		6 / 7 MET A  40
TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-3.6A)
 0.45A 2bytA-4arcA:
34.7		 2bytA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		6 / 7 TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.73A 2bytA-4arcA:
34.7		 2bytA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		7 / 7 MET A  40
TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.74A 2bytD-4arcA:
34.8		 2bytD-4arcA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 7 LEU A 761
PHE A 648
PHE A 669
ASN A 734
 None
C  B  23 ( 4.5A)
None
A  B  24 ( 3.2A)
 0.78A 2opxA-4arcA:
undetectable		 2opxA-4arcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 ILE A 768
ARG A 643
ILE A 726
PHE A 669
 None
 1.05A 2q72A-4arcA:
undetectable		 2q72A-4arcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 PHE A 541
TRP A 212
GLY A 529
GLY A 530
 None
 0.97A 2qr2A-4arcA:
2.4
2qr2B-4arcA:
2.7		 2qr2A-4arcA:
13.97
2qr2B-4arcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 5 TRP A 212
GLY A 529
GLY A 530
PHE A 541
 None
 0.95A 2qr2A-4arcA:
2.2
2qr2B-4arcA:
2.7		 2qr2A-4arcA:
13.97
2qr2B-4arcA:
13.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		7 / 8 MET A  40
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.80A 2v0gA-4arcA:
45.3		 2v0gA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 8 MET A  40
SER A 497
TYR A 499
TYR A 527
HIS A 537
 LEU  A1001 ( 4.3A)
None
None
None
LEU  A1001 (-3.6A)
 1.44A 2v0gA-4arcA:
45.3		 2v0gA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		7 / 8 MET A  40
TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.69A 2v0gA-4arcA:
45.3		 2v0gA-4arcA:
45.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 5 TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 533
 LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-4.2A)
 0.57A 2v0gD-4arcA:
34.1		 2v0gD-4arcA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 GLU A 136
TYR A 133
TYR A 132
PRO A 431
 None
 1.27A 2vmyA-4arcA:
undetectable		 2vmyA-4arcA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 12 ILE A 526
LEU A 564
ASN A 723
MET A 647
ALA A  63
 None
None
A  B  14 ( 3.4A)
None
None
 1.13A 3a50D-4arcA:
undetectable		 3a50D-4arcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 12 ILE A 232
ASN A 383
ILE A 399
ALA A 400
PRO A 312
 None
 1.22A 3a51E-4arcA:
undetectable		 3a51E-4arcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 10 VAL A 261
VAL A 326
GLY A 333
VAL A 245
GLY A 331
 None
A  B  76 ( 4.0A)
A  B  76 ( 4.1A)
None
A  B  76 ( 4.8A)
 1.25A 3ls4H-4arcA:
undetectable		 3ls4H-4arcA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 PHE A 348
ALA A 260
ALA A 268
THR A 305
 None
 0.96A 3mdrB-4arcA:
undetectable		 3mdrB-4arcA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 MET A 114
LEU A 115
TRP A  79
GLN A 631
 None
 0.79A 3mnoA-4arcA:
undetectable		 3mnoA-4arcA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 MET A 114
LEU A 115
TRP A  79
GLN A 631
 None
 0.80A 3mnpA-4arcA:
undetectable		 3mnpA-4arcA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		3 / 3 PHE A 253
CYH A 256
HIS A 311
 None
 1.25A 3u9fF-4arcA:
undetectable		 3u9fF-4arcA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		3 / 3 PHE A 253
CYH A 256
HIS A 311
 None
 1.29A 3u9fL-4arcA:
undetectable		 3u9fL-4arcA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 5 ASP A 704
THR A 708
GLU A 731
LYS A 735
 None
None
A  B  22 ( 3.1A)
None
 1.42A 4a3pA-4arcA:
4.2		 4a3pA-4arcA:
14.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		6 / 7 MET A  40
LEU A  41
ASP A  80
SER A 496
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-4.9A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.53A 4aq7A-4arcA:
39.0		 4aq7A-4arcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		6 / 7 MET A  40
LEU A  41
SER A 496
GLU A 532
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-4.9A)
LEU  A1001 ( 3.7A)
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.91A 4aq7A-4arcA:
39.0		 4aq7A-4arcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_D_LEUD902_0
(LEUCINE--TRNA LIGASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		8 / 9 MET A  40
LEU A  41
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-4.9A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.43A 4aq7D-4arcA:
53.4		 4aq7D-4arcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_D_LEUD902_0
(LEUCINE--TRNA LIGASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		8 / 9 MET A  40
LEU A  41
SER A 496
TYR A 499
TYR A 527
GLU A 532
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-4.9A)
LEU  A1001 ( 3.7A)
None
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.76A 4aq7D-4arcA:
53.4		 4aq7D-4arcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		7 / 7 LEU A  41
TYR A  43
ASP A  80
SER A 496
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 (-4.9A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.00A 4arcA-4arcA:
60.8		 4arcA-4arcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.11A 4ek1A-4arcA:
undetectable		 4ek1A-4arcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 7 ILE A 318
PRO A 319
GLY A 353
ALA A 337
 None
 0.95A 4g0uB-4arcA:
undetectable		 4g0uB-4arcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.12A 4g3rA-4arcA:
undetectable		 4g3rA-4arcA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 PHE A 253
LEU A 259
VAL A 245
VAL A 408
 None
 1.10A 4l4cA-4arcA:
undetectable		 4l4cA-4arcA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 9 THR A 492
ALA A  81
THR A 127
ALA A 126
GLY A 429
 None
 1.13A 4qvnK-4arcA:
undetectable
4qvnL-4arcA:
undetectable		 4qvnK-4arcA:
13.30
4qvnL-4arcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 9 THR A 492
ALA A  81
THR A 127
ALA A 126
GLY A 429
 None
 1.13A 4qvnY-4arcA:
undetectable
4qvnZ-4arcA:
undetectable		 4qvnY-4arcA:
13.30
4qvnZ-4arcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 9 THR A 492
ALA A  81
THR A 127
ALA A 126
GLY A 429
 None
 1.16A 4qvqK-4arcA:
undetectable
4qvqL-4arcA:
undetectable		 4qvqK-4arcA:
12.50
4qvqL-4arcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 9 THR A 492
ALA A  81
THR A 127
ALA A 126
GLY A 429
 None
 1.16A 4qvqY-4arcA:
undetectable
4qvqZ-4arcA:
undetectable		 4qvqY-4arcA:
12.50
4qvqZ-4arcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 9 THR A 492
ALA A  81
THR A 127
ALA A 126
GLY A 429
 None
 1.19A 4qwuK-4arcA:
undetectable
4qwuL-4arcA:
undetectable		 4qwuK-4arcA:
13.07
4qwuL-4arcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 9 THR A 492
ALA A  81
THR A 127
ALA A 126
GLY A 429
 None
 1.16A 4qwuY-4arcA:
undetectable
4qwuZ-4arcA:
undetectable		 4qwuY-4arcA:
13.07
4qwuZ-4arcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 8 TRP A 191
GLU A 486
MET A 434
VAL A 452
 None
 1.24A 4uchA-4arcA:
undetectable
4uchB-4arcA:
undetectable		 4uchA-4arcA:
17.95
4uchB-4arcA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 12 LEU A 644
PHE A 669
LEU A 736
LEU A 676
LEU A 776
 None
 1.21A 5iepA-4arcA:
undetectable		 5iepA-4arcA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 10 ALA A 560
HIS A 537
LEU A  38
TYR A 499
GLY A 529
 None
LEU  A1001 (-3.6A)
None
None
None
 1.29A 5zbdB-4arcA:
undetectable		 5zbdB-4arcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 5 ASP A 345
ILE A 232
PHE A 234
TYR A 258
 None
 1.16A 6a93B-4arcA:
2.3		 6a93B-4arcA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 12 PHE A 234
VAL A 236
VAL A 338
PHE A 253
VAL A 320
 None
 1.19A 6ap6A-4arcA:
undetectable		 6ap6A-4arcA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 12 PHE A 234
VAL A 236
VAL A 338
PHE A 253
VAL A 320
 None
 1.19A 6ap6B-4arcA:
undetectable		 6ap6B-4arcA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		6 / 12 LEU A 115
GLY A 116
HIS A 767
GLN A  75
VAL A  73
ASP A 783
 None
 1.47A 6bxlB-4arcA:
2.1		 6bxlB-4arcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		5 / 9 VAL A 835
GLY A 830
ILE A 848
LEU A 854
ARG A 811
 None
None
C  B  56 ( 3.7A)
G  B  19 ( 4.1A)
C  B  47 ( 2.9A)
 1.20A 6c2mC-4arcA:
undetectable		 6c2mC-4arcA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 4 HIS A 265
VAL A 320
LEU A 267
ALA A 334
 None
 1.27A 6d8pB-4arcA:
undetectable		 6d8pB-4arcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4arc LEUCINE--TRNA LIGASE
(Escherichia
coli) 		4 / 6 PRO A  42
ILE A 105
GLY A  78
GLU A 124
 LEU  A1001 ( 4.9A)
None
None
None
 1.11A 6gqiA-4arcA:
undetectable		 6gqiA-4arcA:
20.64