SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4are'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 GLY A 537
GLY A 540
LEU A 550
ASP A 554
 None
 0.81A 1aegA-4areA:
undetectable		 1aegA-4areA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 10 ASN A 455
VAL A 453
TYR A 764
GLY A 454
LEU A 529
 None
 1.02A 1fkoA-4areA:
undetectable		 1fkoA-4areA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 HIS A 523
GLU A 524
HIS A 527
GLU A 555
TYR A 607
 ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
ZN  A1790 (-3.3A)
ZN  A1790 (-2.5A)
None
 0.97A 1j36A-4areA:
undetectable		 1j36A-4areA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 HIS A 523
GLU A 524
HIS A 527
GLU A 555
TYR A 607
 ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
ZN  A1790 (-3.3A)
ZN  A1790 (-2.5A)
None
 0.98A 1j36B-4areA:
undetectable		 1j36B-4areA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 11 HIS A 523
GLU A 524
HIS A 527
GLU A 555
TYR A 607
 ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
ZN  A1790 (-3.3A)
ZN  A1790 (-2.5A)
None
 0.96A 1j37A-4areA:
3.8		 1j37A-4areA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 11 HIS A 523
GLU A 524
HIS A 527
GLU A 555
TYR A 607
 ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
ZN  A1790 (-3.3A)
ZN  A1790 (-2.5A)
None
 0.97A 1j37B-4areA:
4.0		 1j37B-4areA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 ASP A 466
THR A 421
GLU A 710
 None
 0.79A 1pj7A-4areA:
2.5		 1pj7A-4areA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 GLU A 555
HIS A 523
HIS A 527
GLU A 524
 ZN  A1790 (-2.5A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
 0.98A 1v7zD-4areA:
undetectable		 1v7zD-4areA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 GLU A 555
HIS A 523
HIS A 527
GLU A 524
 ZN  A1790 (-2.5A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
 0.97A 1v7zE-4areA:
undetectable		 1v7zE-4areA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 GLU A 555
HIS A 523
HIS A 527
GLU A 524
 ZN  A1790 (-2.5A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
 0.97A 1v7zF-4areA:
undetectable		 1v7zF-4areA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 ASP A 340
TYR A 344
GLU A 381
 P6G  A1791 (-3.4A)
P6G  A1791 ( 3.5A)
None
 0.85A 1vm1A-4areA:
undetectable		 1vm1A-4areA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 10 GLU A 559
LEU A 534
GLN A 530
GLU A 524
SER A 564
 None
None
None
ZN  A1790 (-3.7A)
None
 1.31A 1wrlE-4areA:
undetectable
1wrlF-4areA:
undetectable		 1wrlE-4areA:
8.23
1wrlF-4areA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 PHE A 158
ALA A 195
ILE A 167
PHE A 157
LEU A 124
 None
 0.99A 1xdkF-4areA:
undetectable		 1xdkF-4areA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 LEU A 617
PHE A 625
ARG A 573
 None
 0.74A 1xdkF-4areA:
undetectable		 1xdkF-4areA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 ASN A 548
GLY A 598
THR A 594
PHE A 606
 None
 1.00A 1ykiA-4areA:
undetectable
1ykiB-4areA:
undetectable		 1ykiA-4areA:
16.01
1ykiB-4areA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 THR A 594
PHE A 606
ASN A 548
GLY A 598
 None
 1.00A 1ykiA-4areA:
undetectable
1ykiB-4areA:
undetectable		 1ykiA-4areA:
16.01
1ykiB-4areA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 8 TYR A 599
ASN A 548
GLY A 598
THR A 594
PHE A 606
 None
 1.43A 1ykiC-4areA:
undetectable
1ykiD-4areA:
undetectable		 1ykiC-4areA:
16.01
1ykiD-4areA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 THR A 594
PHE A 606
ASN A 548
GLY A 598
 None
 1.00A 1ykiC-4areA:
undetectable
1ykiD-4areA:
undetectable		 1ykiC-4areA:
16.01
1ykiD-4areA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 7 TYR A 764
ASP A 456
TYR A 533
TYR A 528
 None
 1.50A 2bytD-4areA:
2.5		 2bytD-4areA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 HIS A 523
GLU A 524
HIS A 527
GLU A 555
TYR A 607
 ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
ZN  A1790 (-3.3A)
ZN  A1790 (-2.5A)
None
 1.04A 2c6nB-4areA:
undetectable		 2c6nB-4areA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 ASP A 678
LEU A 681
LYS A 682
ARG A 437
 None
 1.18A 2gj5A-4areA:
undetectable		 2gj5A-4areA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 TYR A 764
ASP A 456
TYR A 533
TYR A 528
 None
 1.49A 2v0gD-4areA:
3.4		 2v0gD-4areA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 6 ASP A 456
TYR A 778
PHE A 782
LEU A 743
 None
 1.19A 2w98A-4areA:
undetectable
2w98B-4areA:
undetectable		 2w98A-4areA:
18.76
2w98B-4areA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 7 GLU A 555
HIS A 523
HIS A 527
GLU A 524
 ZN  A1790 (-2.5A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
 0.94A 3a6jB-4areA:
2.5		 3a6jB-4areA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 GLU A 555
HIS A 523
HIS A 527
GLU A 524
 ZN  A1790 (-2.5A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
 0.95A 3a6jF-4areA:
undetectable		 3a6jF-4areA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 LEU A 322
GLU A 294
ILE A 293
 None
 0.57A 3czhA-4areA:
undetectable		 3czhA-4areA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 LEU A 720
GLY A 784
TRP A 755
LEU A 747
PHE A 782
 None
 1.47A 3h52C-4areA:
undetectable		 3h52C-4areA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 LEU A 720
VAL A 785
TRP A 755
LEU A 747
PHE A 782
 None
 1.39A 3h52C-4areA:
undetectable		 3h52C-4areA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 7 TYR A 439
PHE A 417
ASN A 419
GLY A 420
 None
 1.11A 3kmoB-4areA:
2.6		 3kmoB-4areA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 THR A 719
SER A 447
HIS A 450
ARG A 443
 None
 0.87A 3kp2A-4areA:
undetectable
3kp2B-4areA:
undetectable		 3kp2A-4areA:
12.18
3kp2B-4areA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 PHE A 611
ILE A 576
GLY A 563
HIS A 615
 None
 1.37A 3r0lD-4areA:
undetectable		 3r0lD-4areA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 ASN A 203
GLY A 159
SER A 154
GLY A 200
ASN A 125
 None
 1.31A 3r24A-4areA:
undetectable		 3r24A-4areA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 11 HIS A 523
GLU A 524
HIS A 527
GLU A 555
TYR A 607
 ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
ZN  A1790 (-3.3A)
ZN  A1790 (-2.5A)
None
 1.00A 4c2pA-4areA:
3.8		 4c2pA-4areA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 GLU A 663
ASP A 666
LEU A 577
ALA A 581
ARG A 588
 None
 1.22A 4cpzE-4areA:
undetectable		 4cpzE-4areA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 ARG A 443
THR A 717
GLU A 710
THR A 719
 None
 1.31A 4eahA-4areA:
4.0
4eahE-4areA:
4.0
4eahG-4areA:
undetectable		 4eahA-4areA:
19.33
4eahE-4areA:
19.33
4eahG-4areA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 4 SER A 475
GLY A 373
GLU A 381
 None
 0.58A 4juoA-4areA:
3.4
4juoC-4areA:
undetectable		 4juoA-4areA:
22.53
4juoC-4areA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 TYR A 525
ARG A 443
SER A 442
 None
 0.94A 4khpI-4areA:
undetectable
4khpJ-4areA:
undetectable		 4khpI-4areA:
11.50
4khpJ-4areA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 6 LEU A 325
LEU A 322
GLU A 321
ILE A 290
 None
 0.96A 4ww7A-4areA:
undetectable		 4ww7A-4areA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 TYR A 439
ASP A 418
ILE A 424
TYR A 714
 None
 1.01A 4xjeA-4areA:
2.3		 4xjeA-4areA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 PHE A 515
ARG A 573
ILE A 576
GLU A 559
 None
 1.43A 4zzcC-4areA:
1.7
4zzcD-4areA:
1.7		 4zzcC-4areA:
19.15
4zzcD-4areA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD401_0
(PROTON-GATED ION
CHANNEL)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 PHE A 515
ARG A 573
ILE A 576
GLU A 559
 None
 1.49A 4zzcD-4areA:
1.7
4zzcE-4areA:
1.7		 4zzcD-4areA:
19.15
4zzcE-4areA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE401_0
(PROTON-GATED ION
CHANNEL)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 ARG A 573
ILE A 576
GLU A 559
PHE A 515
 None
 1.45A 4zzcA-4areA:
1.7
4zzcE-4areA:
1.7		 4zzcA-4areA:
19.15
4zzcE-4areA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 VAL A 781
THR A 719
ARG A 721
 None
 0.73A 5b2sB-4areA:
1.5		 5b2sB-4areA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 VAL A 781
THR A 719
ARG A 721
 None
 0.76A 5b2tB-4areA:
2.4		 5b2tB-4areA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 8 ILE A 315
PHE A 349
VAL A 259
GLU A 294
 None
 1.12A 5dqyA-4areA:
undetectable		 5dqyA-4areA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 7 VAL A 378
GLU A 381
ASN A 287
ILE A 290
 None
None
P6G  A1791 ( 4.3A)
None
 1.19A 5jh7C-4areA:
undetectable		 5jh7C-4areA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 5 ALA A 366
ALA A 379
ILE A 343
LEU A 346
 None
 0.82A 5jncD-4areA:
undetectable		 5jncD-4areA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		3 / 3 ARG A 508
ILE A 514
PHE A 515
 None
 0.71A 5kirA-4areA:
undetectable		 5kirA-4areA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		5 / 12 ALA A 700
THR A 725
THR A 746
LEU A 747
PHE A 782
 None
 1.08A 5ybbA-4areA:
2.5		 5ybbA-4areA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 7 ARG A 437
GLU A 444
TRP A 440
THR A 760
 None
 1.48A 6a4iB-4areA:
2.9		 6a4iB-4areA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4are COLLAGENASE G
(Hathewaya
histolytica) 		4 / 6 PRO A 572
HIS A 615
HIS A 660
GLU A 619
 None
 1.08A 6pahA-4areA:
undetectable		 6pahA-4areA:
17.86