SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4arr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 1v54A-4arrA:
undetectable
1v54C-4arrA:
undetectable		 1v54A-4arrA:
19.22
1v54C-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 1v54N-4arrA:
undetectable
1v54P-4arrA:
undetectable		 1v54N-4arrA:
19.22
1v54P-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 1v55A-4arrA:
undetectable
1v55C-4arrA:
undetectable		 1v55A-4arrA:
19.22
1v55C-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 12 LEU A 179
ILE A 185
MET A 212
PHE A 204
ILE A 202
 None
 1.33A 1xotA-4arrA:
undetectable		 1xotA-4arrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.28A 2dyrA-4arrA:
undetectable
2dyrC-4arrA:
undetectable		 2dyrA-4arrA:
19.22
2dyrC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 2dyrN-4arrA:
undetectable
2dyrP-4arrA:
undetectable		 2dyrN-4arrA:
19.22
2dyrP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.23A 2dysA-4arrA:
undetectable
2dysC-4arrA:
undetectable		 2dysA-4arrA:
19.22
2dysC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.23A 2dysN-4arrA:
undetectable
2dysP-4arrA:
undetectable		 2dysN-4arrA:
19.22
2dysP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.24A 2eijA-4arrA:
undetectable
2eijC-4arrA:
undetectable		 2eijA-4arrA:
19.22
2eijC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 2eijN-4arrA:
undetectable
2eijP-4arrA:
undetectable		 2eijN-4arrA:
19.22
2eijP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 2eikA-4arrA:
undetectable
2eikC-4arrA:
undetectable		 2eikA-4arrA:
19.22
2eikC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 2eikN-4arrA:
undetectable
2eikP-4arrA:
undetectable		 2eikN-4arrA:
19.22
2eikP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 2eilA-4arrA:
undetectable
2eilC-4arrA:
undetectable		 2eilA-4arrA:
19.22
2eilC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 2eilN-4arrA:
undetectable
2eilP-4arrA:
undetectable		 2eilN-4arrA:
19.22
2eilP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.20A 2eimA-4arrA:
undetectable
2eimC-4arrA:
undetectable		 2eimA-4arrA:
19.22
2eimC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 2eimN-4arrA:
undetectable
2eimP-4arrA:
undetectable		 2eimN-4arrA:
19.22
2eimP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.20A 2einA-4arrA:
undetectable
2einC-4arrA:
undetectable		 2einA-4arrA:
19.22
2einC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.19A 2einN-4arrA:
undetectable
2einP-4arrA:
undetectable		 2einN-4arrA:
19.22
2einP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 2y69A-4arrA:
undetectable
2y69C-4arrA:
undetectable		 2y69A-4arrA:
19.22
2y69C-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 2zxwA-4arrA:
undetectable
2zxwC-4arrA:
undetectable		 2zxwA-4arrA:
19.22
2zxwC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 2zxwN-4arrA:
undetectable
2zxwP-4arrA:
undetectable		 2zxwN-4arrA:
19.22
2zxwP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.29A 3abkA-4arrA:
undetectable
3abkC-4arrA:
undetectable		 3abkA-4arrA:
19.22
3abkC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.28A 3abkN-4arrA:
undetectable
3abkP-4arrA:
undetectable		 3abkN-4arrA:
19.22
3abkP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.24A 3abmN-4arrA:
undetectable
3abmP-4arrA:
undetectable		 3abmN-4arrA:
19.22
3abmP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.29A 3ag1A-4arrA:
undetectable
3ag1C-4arrA:
undetectable		 3ag1A-4arrA:
19.22
3ag1C-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.29A 3ag1N-4arrA:
undetectable
3ag1P-4arrA:
undetectable		 3ag1N-4arrA:
19.22
3ag1P-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.29A 3ag2A-4arrA:
undetectable
3ag2C-4arrA:
undetectable		 3ag2A-4arrA:
19.22
3ag2C-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.28A 3ag2N-4arrA:
undetectable
3ag2P-4arrA:
undetectable		 3ag2N-4arrA:
19.22
3ag2P-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.29A 3ag3A-4arrA:
undetectable
3ag3C-4arrA:
undetectable		 3ag3A-4arrA:
19.22
3ag3C-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 3ag3N-4arrA:
undetectable
3ag3P-4arrA:
undetectable		 3ag3N-4arrA:
19.22
3ag3P-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 3ag4A-4arrA:
undetectable
3ag4C-4arrA:
undetectable		 3ag4A-4arrA:
19.22
3ag4C-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 3ag4N-4arrA:
undetectable
3ag4P-4arrA:
undetectable		 3ag4N-4arrA:
19.22
3ag4P-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.30A 3asnA-4arrA:
undetectable
3asnC-4arrA:
undetectable		 3asnA-4arrA:
19.22
3asnC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 9 GLY A  97
ASP A  73
GLY A  30
LEU A  67
VAL A  75
 None
 0.96A 3u7sB-4arrA:
undetectable		 3u7sB-4arrA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 5 SER A 260
ASP A 238
ASP A 242
ILE A 240
 None
 1.34A 3uj7B-4arrA:
undetectable		 3uj7B-4arrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 5 LEU A  90
PRO A  91
LEU A 122
ILE A 118
 None
 0.99A 4klrA-4arrA:
undetectable		 4klrA-4arrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 ARG A 101
THR A 128
THR A 129
VAL A  75
 None
None
I3C  A1300 (-4.4A)
None
 0.98A 4qwpB-4arrA:
undetectable		 4qwpB-4arrA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		3 / 3 ARG A 210
GLN A 211
GLU A 187
 None
 0.93A 4tvtA-4arrA:
undetectable		 4tvtA-4arrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.28A 5b1aN-4arrA:
undetectable
5b1aP-4arrA:
undetectable		 5b1aN-4arrA:
19.22
5b1aP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.27A 5b1bN-4arrA:
undetectable
5b1bP-4arrA:
undetectable		 5b1bN-4arrA:
19.22
5b1bP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.28A 5iy5A-4arrA:
undetectable
5iy5C-4arrA:
undetectable		 5iy5A-4arrA:
19.22
5iy5C-4arrA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.24A 5x19N-4arrA:
undetectable
5x19P-4arrA:
undetectable		 5x19N-4arrA:
19.22
5x19P-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.30A 5zcqN-4arrA:
undetectable
5zcqP-4arrA:
undetectable		 5zcqN-4arrA:
19.22
5zcqP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 TYR A 121
CSS A  56
CSS A  43
LEU A  67
 None
 1.41A 6cnkB-4arrA:
undetectable
6cnkC-4arrA:
undetectable		 6cnkB-4arrA:
15.33
6cnkC-4arrA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 GLY A 280
TRP A 251
ALA A 229
LEU A 252
 None
 1.09A 6fosA-4arrA:
undetectable		 6fosA-4arrA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.25A 6nknA-4arrA:
undetectable
6nknC-4arrA:
undetectable		 6nknA-4arrA:
19.22
6nknC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.25A 6nmfN-4arrA:
undetectable
6nmfP-4arrA:
undetectable		 6nmfN-4arrA:
19.22
6nmfP-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.26A 6nmpA-4arrA:
undetectable
6nmpC-4arrA:
undetectable		 6nmpA-4arrA:
19.22
6nmpC-4arrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS A 145
ASP A  83
THR A  84
TYR A  87
 None
 1.22A 6nmpN-4arrA:
undetectable
6nmpP-4arrA:
undetectable		 6nmpN-4arrA:
19.22
6nmpP-4arrA:
19.93