SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ars'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 10 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.43A 1a52B-4arsA:
undetectable		 1a52B-4arsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 9 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.40A 1ereA-4arsA:
undetectable		 1ereA-4arsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 9 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.39A 1ereB-4arsA:
undetectable		 1ereB-4arsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 9 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.40A 1ereC-4arsA:
undetectable		 1ereC-4arsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 9 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.38A 1ereD-4arsA:
undetectable		 1ereD-4arsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 4 THR A  35
LEU A 172
LEU A 165
GLN A 162
 None
 1.23A 1fbmA-4arsA:
undetectable		 1fbmA-4arsA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 11 LEU A 220
PRO A 175
PHE A 174
LEU A 172
PRO A  36
 None
 1.48A 1klmA-4arsA:
undetectable		 1klmA-4arsA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 10 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.37A 1qkuA-4arsA:
undetectable		 1qkuA-4arsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 10 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.38A 1qkuB-4arsA:
undetectable		 1qkuB-4arsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 10 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.37A 1qkuC-4arsA:
undetectable		 1qkuC-4arsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 10 GLY A 271
LEU A 274
LEU A 275
ILE A 278
LEU A 336
 None
 1.04A 2f8dA-4arsA:
undetectable		 2f8dA-4arsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 10 GLY A 271
LEU A 274
LEU A 275
ILE A 278
LEU A 336
 None
 1.05A 2f8dB-4arsA:
undetectable		 2f8dB-4arsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 11 GLU A  54
GLY A  53
LEU A  56
PRO A 332
SER A  17
 None
 1.32A 2h21B-4arsA:
undetectable		 2h21B-4arsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 11 GLU A  54
GLY A  53
LEU A  56
PRO A 332
SER A  17
 None
 1.35A 2h21C-4arsA:
undetectable		 2h21C-4arsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 8 LEU A 395
ASP A 343
ARG A 340
GLU A  11
 None
 1.07A 2j2pA-4arsA:
undetectable
2j2pB-4arsA:
undetectable		 2j2pA-4arsA:
19.18
2j2pB-4arsA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 8 LEU A 368
PRO A 331
VAL A  21
GLY A  20
 None
 0.83A 2qd5A-4arsA:
undetectable		 2qd5A-4arsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 8 LEU A 368
SER A  17
VAL A  21
GLY A  53
 None
 1.00A 2qd5A-4arsA:
undetectable		 2qd5A-4arsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 8 LEU A 368
SER A  17
VAL A  21
GLY A  53
 None
 1.02A 2qd5B-4arsA:
undetectable		 2qd5B-4arsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		3 / 3 GLY A 205
ASP A 204
SER A 136
 None
 0.74A 2qhfA-4arsA:
undetectable		 2qhfA-4arsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 6 LEU A 126
ASP A 124
TRP A  88
ILE A 303
 None
 1.08A 2rlfB-4arsA:
undetectable
2rlfC-4arsA:
undetectable		 2rlfB-4arsA:
5.72
2rlfC-4arsA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 LEU A 225
ASP A 328
GLU A 222
GLY A  20
HIS A  19
 None
 1.40A 2zj0A-4arsA:
undetectable		 2zj0A-4arsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 6 LEU A 220
GLY A 215
LEU A 172
SER A 169
 None
 0.92A 3aiaA-4arsA:
undetectable		 3aiaA-4arsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 LEU A 225
ASP A 328
GLU A 222
GLY A  20
HIS A  19
 None
 1.42A 3ce6A-4arsA:
undetectable		 3ce6A-4arsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 LEU A 225
ASP A 328
GLU A 222
GLY A  20
HIS A  19
 None
 1.43A 3ce6C-4arsA:
undetectable		 3ce6C-4arsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		3 / 3 ASN A 298
ALA A  84
LYS A 299
 None
 1.01A 3runA-4arsA:
undetectable		 3runA-4arsA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 6 ASN A 254
ASP A 307
GLY A 334
THR A 322
 None
None
None
GOL  A1419 (-4.4A)
 0.92A 4l1aB-4arsA:
undetectable		 4l1aB-4arsA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 ALA A  89
LEU A 103
PHE A 102
ILE A 300
ILE A  15
 None
 1.11A 4nx6A-4arsA:
undetectable		 4nx6A-4arsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 ALA A  89
LEU A 103
PHE A 102
ILE A 300
ILE A  15
 None
 1.13A 4nx7A-4arsA:
undetectable		 4nx7A-4arsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 ALA A 101
LEU A 103
MET A  60
LEU A  59
GLY A 334
 None
 0.99A 4xi3C-4arsA:
undetectable		 4xi3C-4arsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 ALA A  89
LEU A 103
PHE A 102
ILE A 300
ILE A  15
 None
 1.07A 5e8qA-4arsA:
undetectable		 5e8qA-4arsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 7 ILE A  15
VAL A 402
ILE A 313
ASN A 298
 None
 1.00A 5hieC-4arsA:
undetectable		 5hieC-4arsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 LEU A 323
HIS A 253
GLN A 357
ARG A  22
GLY A  20
 None
 1.34A 5m50E-4arsA:
undetectable		 5m50E-4arsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 ALA A  89
PRO A 331
TYR A  64
ALA A 304
GLY A 305
 None
 1.26A 5tzoC-4arsA:
undetectable		 5tzoC-4arsA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 7 PHE A 224
MET A 168
MET A  27
THR A  35
 None
 1.38A 5u6mB-4arsA:
undetectable		 5u6mB-4arsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 8 PHE A 224
MET A 168
MET A  27
THR A  35
 None
 1.30A 5u6nA-4arsA:
undetectable		 5u6nA-4arsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		5 / 12 TYR A 179
PHE A 174
GLY A 212
ALA A 213
LEU A 165
 None
 1.06A 5zwrA-4arsA:
undetectable		 5zwrA-4arsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		4 / 8 TRP A 321
THR A 330
PRO A 331
ILE A 310
 GOL  A1415 ( 3.8A)
GOL  A1415 ( 4.4A)
None
None
 0.84A 6a4iA-4arsA:
undetectable		 6a4iA-4arsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		3 / 3 LEU A 370
GLN A 371
LYS A  76
 None
 0.85A 6exiB-4arsA:
2.0		 6exiB-4arsA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4ars HISTIDINE ACID
PHOSPHATASE
(Hafnia
alvei) 		3 / 3 LEU A 370
GLN A 371
LYS A  76
 None
 0.92A 6exiA-4arsA:
undetectable		 6exiA-4arsA:
12.53