SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4art'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4art STRUCTURAL PROTEIN
ORF273
(Acidianus
two-tailed
virus) 		5 / 12 ILE A 162
ILE A 116
TYR A 140
TYR A  60
ALA A  70
 None
None
None
None
GOL  A1271 (-4.2A)
 1.09A 1jtxA-4artA:
undetectable		 1jtxA-4artA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4art STRUCTURAL PROTEIN
ORF273
(Acidianus
two-tailed
virus) 		4 / 6 LEU A 264
PHE A 102
ASP A  98
GLU A 267
 None
 1.26A 2vn1B-4artA:
undetectable		 2vn1B-4artA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4art STRUCTURAL PROTEIN
ORF273
(Acidianus
two-tailed
virus) 		4 / 7 TYR A  73
PRO A  69
GLU A  38
ARG A  82
 None
 1.11A 3s3oA-4artA:
undetectable		 3s3oA-4artA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4art STRUCTURAL PROTEIN
ORF273
(Acidianus
two-tailed
virus) 		4 / 7 GLU A  36
ILE A  67
LEU A 137
ILE A 141
 None
 0.96A 4xumA-4artA:
undetectable		 4xumA-4artA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4art STRUCTURAL PROTEIN
ORF273
(Acidianus
two-tailed
virus) 		4 / 7 TYR A 140
GLU A  92
ASP A  94
GLU A 101
 None
 1.22A 6mn5B-4artA:
undetectable		 6mn5B-4artA:
12.82