SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4arv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 7 LEU A 155
LEU A 215
GLY A 211
LEU A 209
 None
 0.77A 1gtiA-4arvA:
undetectable		 1gtiA-4arvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 7 LEU A 209
ILE A 222
THR A 218
GLN A  26
 None
EDO  A1417 (-4.7A)
EDO  A1417 (-4.2A)
None
 1.15A 1kglA-4arvA:
undetectable		 1kglA-4arvA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 7 GLU A 339
ILE A 378
TRP A 341
LEU A 394
 None
None
TOE  A1420 ( 3.9A)
TOE  A1420 ( 4.9A)
 1.41A 1q0yH-4arvA:
undetectable
1q0yL-4arvA:
undetectable		 1q0yH-4arvA:
18.51
1q0yL-4arvA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 10 GLY A 270
LEU A 273
LEU A 274
ILE A 277
LEU A 336
 None
 0.93A 2f8dA-4arvA:
undetectable		 2f8dA-4arvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 10 GLY A 270
LEU A 273
LEU A 274
ILE A 277
LEU A 336
 None
 0.94A 2f8dB-4arvA:
undetectable		 2f8dB-4arvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 8 LEU A 369
PRO A 331
VAL A  20
GLY A  19
 None
 0.87A 2qd5A-4arvA:
undetectable		 2qd5A-4arvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 8 LEU A 369
SER A  16
VAL A  20
GLY A  52
 None
 1.02A 2qd5A-4arvA:
undetectable		 2qd5A-4arvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 8 LEU A 369
SER A  16
VAL A  20
GLY A  52
 None
 1.06A 2qd5B-4arvA:
undetectable		 2qd5B-4arvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 6 LYS A 261
LEU A 323
ASN A 329
ASP A 307
 None
None
None
PO4  A1415 (-2.8A)
 1.36A 2w98A-4arvA:
undetectable
2w98B-4arvA:
undetectable		 2w98A-4arvA:
22.57
2w98B-4arvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 LEU A 224
ASP A 328
GLU A 221
GLY A  19
HIS A  18
 None
None
None
None
PO4  A1415 (-3.9A)
 1.44A 2zj0A-4arvA:
undetectable		 2zj0A-4arvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 LEU A 224
ASP A 328
GLU A 221
GLY A  19
HIS A  18
 None
None
None
None
PO4  A1415 (-3.9A)
 1.46A 3ce6A-4arvA:
undetectable		 3ce6A-4arvA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 LEU A 224
ASP A 328
GLU A 221
GLY A  19
HIS A  18
 None
None
None
None
PO4  A1415 (-3.9A)
 1.47A 3ce6C-4arvA:
undetectable		 3ce6C-4arvA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 PHE A 223
VAL A  33
LEU A  29
GLN A  26
THR A  27
 None
 1.37A 3elzC-4arvA:
undetectable		 3elzC-4arvA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 THR A 291
LEU A 124
VAL A 132
GLY A 131
ILE A 408
 None
 1.09A 3ijdA-4arvA:
undetectable		 3ijdA-4arvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 6 MET A 360
LEU A 363
TRP A  41
GLN A 326
 None
 1.26A 3mnoA-4arvA:
0.0		 3mnoA-4arvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 6 MET A 360
LEU A 363
TRP A  41
GLN A 326
 None
 1.23A 3mnpA-4arvA:
undetectable		 3mnpA-4arvA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 5 LEU A 224
ARG A  17
LEU A 249
PRO A 327
 None
PO4  A1415 (-4.0A)
None
None
 1.36A 3onnA-4arvA:
undetectable		 3onnA-4arvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 4 ASN A 171
SER A 247
LEU A 165
THR A  34
 None
 1.19A 4an2A-4arvA:
undetectable		 4an2A-4arvA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 GLU A 361
GLN A 358
ASN A 365
LEU A  58
LEU A  48
 None
 1.43A 4k36A-4arvA:
undetectable		 4k36A-4arvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 GLU A 361
GLN A 358
ASN A 365
LEU A  58
LEU A  48
 None
 1.47A 4k36B-4arvA:
undetectable		 4k36B-4arvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 5 GLN A 290
THR A 291
LEU A  15
LEU A 303
 None
 1.12A 4lvcB-4arvA:
undetectable		 4lvcB-4arvA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 7 ASP A  88
ARG A  92
PHE A 125
HIS A 126
 PO4  A1416 ( 4.6A)
PO4  A1416 ( 3.2A)
None
PO4  A1416 (-4.1A)
 1.18A 4o4dA-4arvA:
undetectable		 4o4dA-4arvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 ALA A  99
LEU A 101
MET A  59
LEU A  58
GLY A 334
 None
 0.95A 4xi3C-4arvA:
undetectable		 4xi3C-4arvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 4 GLN A 290
THR A 291
LEU A  15
LEU A 303
 None
 1.14A 5m5kB-4arvA:
undetectable		 5m5kB-4arvA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4arv PHYTASE
(Yersinia
kristensenii) 		5 / 12 LEU A 317
ILE A 313
ASP A 257
THR A 262
ASN A 320
 None
 1.23A 5nfjB-4arvA:
undetectable		 5nfjB-4arvA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4arv PHYTASE
(Yersinia
kristensenii) 		4 / 8 TRP A 321
THR A 330
PRO A 331
ILE A 310
 None
 0.92A 6a4iA-4arvA:
undetectable		 6a4iA-4arvA:
19.83