SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4arx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 7 PHE A 579
ARG A 526
TRP A 545
SER A 582
 None
 1.45A 1gyxA-4arxA:
undetectable
1gyxB-4arxA:
0.0		 1gyxA-4arxA:
9.49
1gyxB-4arxA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 11 LEU A  60
PHE A  56
GLY A  59
LEU A  46
LEU A  42
 None
 1.27A 1mx1B-4arxA:
undetectable		 1mx1B-4arxA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 GLU A 274
ASN A 270
TRP A 226
 None
 1.24A 1r15C-4arxA:
undetectable		 1r15C-4arxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 GLU A 274
ASN A 270
TRP A 226
 None
 1.25A 1r15D-4arxA:
undetectable		 1r15D-4arxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 GLU A 274
ASN A 270
TRP A 226
 None
 1.25A 1r15E-4arxA:
undetectable		 1r15E-4arxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 GLU A 274
ASN A 270
TRP A 226
 None
 1.28A 1r15F-4arxA:
undetectable		 1r15F-4arxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.18A 1ya3A-4arxA:
undetectable		 1ya3A-4arxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		6 / 10 ALA A 165
ALA A 164
LEU A 103
LEU A 141
ALA A 144
LEU A 199
 None
 1.46A 2bxgB-4arxA:
3.3		 2bxgB-4arxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 PHE A 247
VAL A 162
ILE A  63
SER A  39
ILE A  64
 None
 1.11A 2ft9A-4arxA:
undetectable		 2ft9A-4arxA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 10 THR A 361
HIS A 319
THR A 386
PRO A 451
ILE A 303
 None
 1.22A 2y7wB-4arxA:
undetectable		 2y7wB-4arxA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 LEU A 541
ASN A 591
ALA A 476
ILE A 539
THR A 558
 None
 1.09A 3czhB-4arxA:
undetectable		 3czhB-4arxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 ASN A 194
ARG A 192
ASN A 138
HIS A 168
 None
 1.27A 3frqA-4arxA:
undetectable		 3frqA-4arxA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 7 ASN A 194
ARG A 192
ASN A 138
HIS A 168
 None
 1.26A 3frqB-4arxA:
undetectable		 3frqB-4arxA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 4 ILE A 466
PHE A 605
ILE A 518
THR A 525
 None
 1.13A 3ia4A-4arxA:
undetectable		 3ia4A-4arxA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 HIS A 319
SER A 363
ASN A 270
 None
 0.89A 3s8pB-4arxA:
undetectable		 3s8pB-4arxA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 7 PHE A 462
PHE A 328
ASN A 301
ALA A 352
 None
 1.09A 4ejgA-4arxA:
1.6		 4ejgA-4arxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 GLY A 201
THR A 494
VAL A 208
ASP A 205
 None
 1.10A 4eohA-4arxA:
2.8		 4eohA-4arxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 10 THR A 264
GLY A 479
VAL A 487
ASP A 497
VAL A 499
 None
 1.09A 4jx1B-4arxA:
undetectable		 4jx1B-4arxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 SER A 176
TYR A 193
PRO A  52
 None
 0.98A 4k8cA-4arxA:
undetectable		 4k8cA-4arxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 SER A 176
TYR A 193
PRO A  52
 None
 0.98A 4kanB-4arxA:
undetectable		 4kanB-4arxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 SER A 176
TYR A 193
PRO A  52
 None
 0.97A 4kbeB-4arxA:
undetectable		 4kbeB-4arxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 5 SER A 176
ARG A 173
LEU A 196
ASP A 251
 None
 1.49A 4xdtA-4arxA:
undetectable		 4xdtA-4arxA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 8 ASN A 270
PRO A 271
PHE A 453
SER A 454
 None
 1.10A 5amiB-4arxA:
undetectable		 5amiB-4arxA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 GLY A 495
PRO A 475
ARG A 532
LEU A 241
LEU A 263
 None
 1.27A 5bw4B-4arxA:
undetectable		 5bw4B-4arxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		5 / 12 ILE A 303
LEU A 383
GLY A 357
PHE A 388
THR A 386
 None
 1.07A 5byjA-4arxA:
undetectable		 5byjA-4arxA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		3 / 3 HIS A 319
SER A 363
ASN A 270
 None
 0.87A 5cprB-4arxA:
undetectable		 5cprB-4arxA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 8 ALA A 245
ASN A 249
HIS A 457
THR A  43
 None
 1.09A 5db5A-4arxA:
undetectable
5db5B-4arxA:
undetectable		 5db5A-4arxA:
21.31
5db5B-4arxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 6 GLY A 425
ASP A  62
ILE A  38
TYR A  33
 None
 1.10A 5iwuA-4arxA:
undetectable		 5iwuA-4arxA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC
(Bacillus
thuringiensis) 		4 / 6 ARG A 368
VAL A 382
LEU A 366
ARG A 402
 None
 0.86A 5x7zA-4arxA:
1.9		 5x7zA-4arxA:
13.66