SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4as3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 192
LYS A 187
ALA A 186
MET A 156
 None
 1.11A 1hk2A-4as3A:
undetectable		 1hk2A-4as3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 165
VAL A  29
ALA A 314
TRP A 318
GLY A 261
 None
 1.04A 1kiaA-4as3A:
5.1		 1kiaA-4as3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 165
VAL A  29
ALA A 314
TRP A 318
GLY A 261
 None
 1.05A 1kiaB-4as3A:
5.1		 1kiaB-4as3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 165
VAL A  29
ALA A 314
TRP A 318
GLY A 261
 None
 1.05A 1kiaC-4as3A:
5.0		 1kiaC-4as3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 165
VAL A  29
ALA A 314
TRP A 318
GLY A 261
 None
 1.07A 1nbhB-4as3A:
2.6		 1nbhB-4as3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 165
VAL A  29
ALA A 314
TRP A 318
GLY A 261
 None
 1.11A 1nbiA-4as3A:
4.9		 1nbiA-4as3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 165
VAL A  29
ALA A 314
TRP A 318
GLY A 261
 None
 1.13A 1nbiB-4as3A:
5.0		 1nbiB-4as3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 320
ILE A 294
MET A 291
LEU A 151
 None
 0.84A 1zgyA-4as3A:
undetectable		 1zgyA-4as3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  42
GLU A  43
ASP A  31
ASP A 265
ASP A  33
 BTB  A1330 ( 4.6A)
BTB  A1332 ( 3.4A)
MG  A1328 ( 2.6A)
BTB  A1331 (-4.0A)
BTB  A1330 (-4.5A)
 1.34A 2b0qA-4as3A:
1.1		 2b0qA-4as3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 321
LEU A 155
ILE A  18
LEU A  17
 None
 1.04A 2byoA-4as3A:
undetectable		 2byoA-4as3A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A 195
PRO A 235
TYR A 249
 None
 0.70A 2dxrA-4as3A:
undetectable		 2dxrA-4as3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 128
TYR A  83
PHE A  69
LEU A  79
 None
 1.01A 2w98A-4as3A:
7.0
2w98B-4as3A:
7.3		 2w98A-4as3A:
21.08
2w98B-4as3A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 249
GLU A 170
ASN A 223
 None
 0.75A 2y7hC-4as3A:
undetectable		 2y7hC-4as3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A  36
ASP A 267
LEU A 271
TRP A 283
 None
CL  A1329 ( 4.0A)
None
None
 1.18A 3n2oC-4as3A:
2.1
3n2oD-4as3A:
undetectable		 3n2oC-4as3A:
19.49
3n2oD-4as3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 239
ASP A 267
VAL A  98
TYR A  83
 None
CL  A1329 ( 4.0A)
None
None
 1.10A 3p6hA-4as3A:
undetectable		 3p6hA-4as3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 260
PHE A  30
ASN A  21
ILE A 160
ILE A  18
 None
 1.02A 4nkvA-4as3A:
undetectable		 4nkvA-4as3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 260
PHE A  30
ASN A  21
ILE A 160
ILE A  18
 None
 1.01A 4nkvC-4as3A:
undetectable		 4nkvC-4as3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 260
PHE A  30
ASN A  21
ILE A 160
ILE A  18
 None
 1.01A 4nkvD-4as3A:
undetectable		 4nkvD-4as3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A  83
GLU A  43
GLU A  42
PHE A 102
 None
BTB  A1332 ( 3.4A)
BTB  A1330 ( 4.6A)
None
 1.37A 4twdA-4as3A:
undetectable
4twdB-4as3A:
undetectable		 4twdA-4as3A:
21.90
4twdB-4as3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A  83
GLU A  43
GLU A  42
PHE A 102
 None
BTB  A1332 ( 3.4A)
BTB  A1330 ( 4.6A)
None
 1.43A 4twdG-4as3A:
undetectable
4twdH-4as3A:
undetectable		 4twdG-4as3A:
21.90
4twdH-4as3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A  83
GLU A  43
GLU A  42
PHE A 102
 None
BTB  A1332 ( 3.4A)
BTB  A1330 ( 4.6A)
None
 1.41A 4twdH-4as3A:
0.0
4twdI-4as3A:
0.0		 4twdH-4as3A:
21.90
4twdI-4as3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  60
LEU A  79
GLU A  77
TYR A  82
 None
 1.01A 4z4fA-4as3A:
2.3		 4z4fA-4as3A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4as3 PHOSPHORYLCHOLINE
PHOSPHATASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 102
VAL A  98
TYR A  83
ASP A  40
 None
None
None
BTB  A1330 (-2.9A)
 1.31A 5iwuA-4as3A:
undetectable		 5iwuA-4as3A:
23.93