SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4as5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 VAL A 193
LEU A 235
ALA A 252
ASN A 199
VAL A 148
 None
 1.13A 1sa1A-4as5A:
undetectable
1sa1B-4as5A:
undetectable		 1sa1A-4as5A:
22.03
1sa1B-4as5A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 VAL A 193
LEU A 235
ALA A 252
ASN A 199
VAL A 148
 None
 1.12A 1sa1C-4as5A:
undetectable
1sa1D-4as5A:
undetectable		 1sa1C-4as5A:
22.03
1sa1D-4as5A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 7 ARG A 261
GLU A 152
ALA A 210
ALA A 253
 None
 1.02A 2ejfA-4as5A:
undetectable		 2ejfA-4as5A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 GLY A 207
ALA A 208
ASP A 209
GLY A 189
VAL A 193
 None
 0.81A 2fxeA-4as5A:
undetectable		 2fxeA-4as5A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 5 LEU A 258
ILE A 262
ILE A 251
ALA A 252
 None
 0.74A 2i2zA-4as5A:
2.1		 2i2zA-4as5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 ALA A 210
ASP A 209
ILE A 187
GLY A 189
ILE A 262
 None
 1.09A 2o4kA-4as5A:
undetectable		 2o4kA-4as5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.17A 2obvA-4as5A:
undetectable		 2obvA-4as5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.18A 2p02A-4as5A:
undetectable		 2p02A-4as5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 11 SER A 108
TYR A 211
ALA A 224
GLY A 223
ALA A 222
 None
 1.44A 2xh9A-4as5A:
2.0		 2xh9A-4as5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 10 SER A 108
TYR A 211
ALA A 224
GLY A 223
ALA A 222
 None
 1.44A 2xh9B-4as5A:
2.0		 2xh9B-4as5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 9 VAL A 160
ALA A 210
ILE A 154
ILE A 190
TYR A 212
 None
 1.45A 3hbbB-4as5A:
undetectable		 3hbbB-4as5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		3 / 3 ARG A 248
ASP A 244
ASP A 274
 None
 0.89A 3jayA-4as5A:
undetectable		 3jayA-4as5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		3 / 3 ARG A 248
ASP A 244
ASP A 274
 None
 0.93A 3jb2A-4as5A:
undetectable		 3jb2A-4as5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		3 / 3 ARG A 248
ASP A 244
ASP A 274
 None
 0.93A 3jb3A-4as5A:
undetectable		 3jb3A-4as5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 GLY A  94
VAL A 107
ALA A 197
ALA A 196
LEU A  42
 PO4  A 401 (-3.4A)
None
None
None
None
 0.97A 3mteA-4as5A:
undetectable		 3mteA-4as5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 GLY A  94
VAL A 107
ALA A 197
ALA A 196
LEU A  42
 PO4  A 401 (-3.4A)
None
None
None
None
 0.97A 3mteB-4as5A:
undetectable		 3mteB-4as5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 ALA A 224
ILE A 109
ALA A  16
ASP A  93
GLU A 162
 None
None
None
MG  A 502 ( 3.0A)
None
 1.14A 3nvkI-4as5A:
undetectable		 3nvkI-4as5A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 GLY A  94
VAL A 107
ALA A 197
ALA A 196
LEU A  42
 PO4  A 401 (-3.4A)
None
None
None
None
 0.96A 3p2kC-4as5A:
undetectable		 3p2kC-4as5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 GLY A  94
VAL A 107
ALA A 197
ALA A 196
LEU A  42
 PO4  A 401 (-3.4A)
None
None
None
None
 1.02A 3p2kD-4as5A:
undetectable		 3p2kD-4as5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 12 LEU A 182
ILE A 251
TYR A 212
ILE A 190
VAL A 228
 None
 1.26A 3vw1D-4as5A:
undetectable		 3vw1D-4as5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.17A 4kttA-4as5A:
undetectable		 4kttA-4as5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.19A 4kttC-4as5A:
undetectable		 4kttC-4as5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.12A 4ndnA-4as5A:
undetectable		 4ndnA-4as5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.19A 4ndnC-4as5A:
undetectable		 4ndnC-4as5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.24A 4odjA-4as5A:
undetectable		 4odjA-4as5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.14A 5a1iA-4as5A:
undetectable		 5a1iA-4as5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.14A 5a1iA-4as5A:
undetectable		 5a1iA-4as5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 ASP A 220
ASP A  93
ASP A  90
ILE A  23
 MG  A 502 ( 2.9A)
MG  A 502 ( 3.0A)
MG  A 502 (-2.4A)
None
 0.96A 5cfsA-4as5A:
undetectable		 5cfsA-4as5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		5 / 9 VAL A 198
ALA A 106
SER A 124
VAL A 193
GLY A  94
 None
None
None
None
PO4  A 401 (-3.4A)
 1.27A 6bklA-4as5A:
undetectable
6bklB-4as5A:
undetectable
6bklC-4as5A:
undetectable
6bklD-4as5A:
undetectable		 6bklA-4as5A:
6.55
6bklB-4as5A:
6.55
6bklC-4as5A:
6.55
6bklD-4as5A:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.15A 6fboA-4as5A:
undetectable		 6fboA-4as5A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.16A 6fcbA-4as5A:
undetectable		 6fcbA-4as5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.15A 6fcdA-4as5A:
undetectable		 6fcdA-4as5A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		3 / 3 THR A  46
ALA A  26
LYS A  28
 EDO  A1280 (-3.5A)
EDO  A1280 ( 3.7A)
None
 0.74A 6fgcA-4as5A:
2.7		 6fgcA-4as5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		3 / 3 THR A  46
ALA A  26
LYS A  28
 EDO  A1280 (-3.5A)
EDO  A1280 ( 3.7A)
None
 0.73A 6fgdA-4as5A:
2.4		 6fgdA-4as5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
 1.13A 6g6rA-4as5A:
undetectable		 6g6rA-4as5A:
21.57