SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4asc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 4 SER A 344
SER A 342
LEU A 383
PHE A 385
 None
 1.23A 1r5lA-4ascA:
undetectable		 1r5lA-4ascA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 SER A 413
TYR A 415
LEU A 429
THR A 356
 None
 1.19A 2v0zO-4ascA:
undetectable		 2v0zO-4ascA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 PHE A 321
LEU A 613
ALA A 341
ALA A 328
VAL A 347
 None
None
CSO  A 340 ( 3.6A)
None
None
 1.13A 3cwkA-4ascA:
undetectable		 3cwkA-4ascA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 VAL A 457
VAL A 352
PHE A 405
VAL A 464
 None
 1.06A 3fhxB-4ascA:
undetectable		 3fhxB-4ascA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 PHE A 321
ILE A 583
ASN A 614
PHE A 608
 None
 1.39A 3octA-4ascA:
undetectable		 3octA-4ascA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 ILE A 562
LEU A 550
GLY A 564
GLY A 563
 None
 0.82A 5a06B-4ascA:
2.3		 5a06B-4ascA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 THR A 524
GLU A 528
HIS A 508
LEU A 552
 None
 1.25A 5utuH-4ascA:
undetectable		 5utuH-4ascA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 VAL A 363
SER A 353
PHE A 321
LEU A 613
VAL A 611
 None
 1.14A 6a93B-4ascA:
undetectable		 6a93B-4ascA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 LEU A 555
ASN A 359
VAL A 355
ARG A 612
 None
 0.95A 6cb4A-4ascA:
undetectable		 6cb4A-4ascA:
23.28