SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4asi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 ALA A1739
VAL A1716
TRP A1699
 None
 0.85A 1av2C-4asiA:
undetectable
1av2D-4asiA:
undetectable		 1av2C-4asiA:
1.86
1av2D-4asiA:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		6 / 12 ILE A1748
SER A1855
ILE A1854
LEU A1936
ARG A1712
ILE A1714
 None
 1.39A 1dhiA-4asiA:
undetectable		 1dhiA-4asiA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		6 / 12 ILE A1748
SER A1855
ILE A1854
LEU A1936
ARG A1712
ILE A1714
 None
 1.37A 1dhjA-4asiA:
undetectable		 1dhjA-4asiA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		6 / 12 ILE A1748
SER A1855
ILE A1854
LEU A1936
ARG A1712
ILE A1714
 None
 1.37A 1draA-4asiA:
undetectable		 1draA-4asiA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
GLY A1872
 None
 0.97A 1igxA-4asiA:
undetectable		 1igxA-4asiA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 VAL A2022
TYR A2118
PHE A1992
LEU A2015
PRO A2019
 None
 1.46A 1klmA-4asiA:
1.3		 1klmA-4asiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 TRP A2004
HIS A1919
MET A2001
 None
 1.09A 1l5qB-4asiA:
2.2		 1l5qB-4asiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 10 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.14A 1pxxA-4asiA:
undetectable		 1pxxA-4asiA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 GLY A1836
SER A1855
GLY A1718
ASN A1719
ILE A1717
 None
 1.01A 1q8jB-4asiA:
undetectable		 1q8jB-4asiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 GLY A1836
SER A1855
ILE A1751
GLY A1718
ASN A1719
 None
 1.18A 1q8jB-4asiA:
undetectable		 1q8jB-4asiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ILE A1748
SER A1855
ILE A1854
LEU A1936
ARG A1712
 None
 1.17A 1rx3A-4asiA:
undetectable		 1rx3A-4asiA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 ALA A1739
VAL A1716
TRP A1699
 None
 0.87A 1w5uC-4asiA:
undetectable
1w5uD-4asiA:
undetectable		 1w5uC-4asiA:
1.86
1w5uD-4asiA:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ILE A1761
GLY A1762
LEU A1763
PRO A1831
SER A1837
 None
 1.06A 1zq9A-4asiA:
undetectable		 1zq9A-4asiA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.01A 2aylA-4asiA:
undetectable		 2aylA-4asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.03A 2aylB-4asiA:
undetectable		 2aylB-4asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		6 / 12 ILE A1748
SER A1855
ILE A1854
LEU A1936
ARG A1712
ILE A1714
 None
 1.38A 2drcA-4asiA:
undetectable		 2drcA-4asiA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 6 THR A1901
ASP A2037
ASN A2040
ASP A2042
 None
 1.26A 2okcA-4asiA:
undetectable		 2okcA-4asiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 GLY A1729
ILE A1635
VAL A1675
SER A1727
 None
 0.89A 2yoeB-4asiA:
undetectable
2yoeC-4asiA:
undetectable		 2yoeB-4asiA:
16.60
2yoeC-4asiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 TYR A2253
LEU A1949
PHE A1992
ILE A1960
PHE A2080
 None
 1.23A 2zzmA-4asiA:
undetectable		 2zzmA-4asiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 TYR A2253
LEU A1949
PHE A1992
ILE A1960
PHE A2080
 None
 1.26A 2zznA-4asiA:
undetectable		 2zznA-4asiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 TYR A2253
LEU A1949
PHE A1992
ILE A1960
PHE A2080
 None
 1.29A 2zznB-4asiA:
undetectable		 2zznB-4asiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 LEU A1871
PHE A1736
ILE A1864
GLY A1865
SER A1754
 None
 1.47A 3bpxA-4asiA:
undetectable
3bpxB-4asiA:
undetectable		 3bpxA-4asiA:
12.15
3bpxB-4asiA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		6 / 12 ILE A1748
SER A1855
ILE A1854
LEU A1936
ARG A1712
ILE A1714
 None
 1.37A 3drcA-4asiA:
undetectable		 3drcA-4asiA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 SER A1837
GLY A1828
GLY A1729
GLY A1836
ILE A1829
 None
 0.99A 3gczA-4asiA:
undetectable		 3gczA-4asiA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 10 PRO A1948
LEU A2260
ILE A2018
PRO A2019
GLY A2017
 None
 1.44A 3iluB-4asiA:
undetectable
3iluE-4asiA:
undetectable		 3iluB-4asiA:
17.56
3iluE-4asiA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 0.99A 3n8wA-4asiA:
undetectable		 3n8wA-4asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.18A 3n8xA-4asiA:
undetectable		 3n8xA-4asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.03A 3n8zA-4asiA:
undetectable		 3n8zA-4asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.02A 3n8zB-4asiA:
undetectable		 3n8zB-4asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 TYR A2118
TYR A2145
ARG A2255
LEU A2256
 None
 1.20A 3wipG-4asiA:
undetectable
3wipH-4asiA:
undetectable		 3wipG-4asiA:
15.49
3wipH-4asiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 ARG A2255
LEU A2256
TYR A2118
TYR A2145
 None
 1.27A 3wipF-4asiA:
undetectable
3wipJ-4asiA:
undetectable		 3wipF-4asiA:
15.49
3wipJ-4asiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 ARG A1750
ASP A2069
GLN A2065
 None
 0.90A 4azsA-4asiA:
undetectable		 4azsA-4asiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 SER A2059
PHE A2061
ARG A1874
VAL A2010
ILE A2067
 None
 1.45A 4b3aA-4asiA:
undetectable		 4b3aA-4asiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 ALA A1739
SER A1740
PHE A1642
ARG A1750
ILE A1751
 None
 1.24A 4bb2A-4asiA:
undetectable
4bb2B-4asiA:
undetectable		 4bb2A-4asiA:
18.10
4bb2B-4asiA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 SER A1740
ARG A1750
GLU A1850
ILE A1851
 None
 1.09A 4d33A-4asiA:
undetectable		 4d33A-4asiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 SER A1740
ARG A1750
GLU A1850
ILE A1851
 None
 1.08A 4d33B-4asiA:
undetectable		 4d33B-4asiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 SER A1740
ARG A1750
GLU A1850
ILE A1851
 None
 1.11A 4d39B-4asiA:
undetectable		 4d39B-4asiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 5 ALA A1861
ILE A1864
LEU A1868
ASN A1756
 None
 1.00A 4g19A-4asiA:
undetectable		 4g19A-4asiA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 LEU A1949
PRO A2114
VAL A2022
GLY A2021
 None
 0.94A 4klrB-4asiA:
undetectable		 4klrB-4asiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 GLU A2124
ASP A2147
ILE A2119
ILE A2239
 None
 0.76A 4kttB-4asiA:
undetectable		 4kttB-4asiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 GLU A2156
LEU A2155
SER A2153
ARG A2151
GLU A2124
 None
 1.43A 4mx0A-4asiA:
undetectable		 4mx0A-4asiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 6 GLU A2073
ILE A1854
HIS A1919
TYR A1848
 None
 1.38A 4qwpA-4asiA:
undetectable		 4qwpA-4asiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 VAL A2030
GLN A2006
LEU A2032
SER A2033
 None
 1.10A 4zphA-4asiA:
undetectable
4zphB-4asiA:
undetectable		 4zphA-4asiA:
19.20
4zphB-4asiA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ALA A2123
ASP A1970
ARG A1972
GLU A1999
 None
 0.99A 5bs8A-4asiA:
undetectable
5bs8B-4asiA:
undetectable
5bs8C-4asiA:
undetectable		 5bs8A-4asiA:
21.83
5bs8B-4asiA:
16.39
5bs8C-4asiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ALA A2123
ASP A1970
ARG A1972
GLU A1999
 None
 0.99A 5btdA-4asiA:
undetectable
5btdB-4asiA:
undetectable
5btdC-4asiA:
undetectable		 5btdA-4asiA:
21.83
5btdB-4asiA:
16.39
5btdC-4asiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ALA A2123
ASP A1970
ARG A1972
GLU A1999
 None
 0.96A 5btdA-4asiA:
undetectable
5btdC-4asiA:
undetectable
5btdD-4asiA:
undetectable		 5btdA-4asiA:
21.83
5btdC-4asiA:
21.83
5btdD-4asiA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 ASP A1970
ALA A2024
LYS A2062
GLU A1999
VAL A2022
 None
 1.29A 5hw4B-4asiA:
undetectable		 5hw4B-4asiA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 PHE A1997
GLY A2017
LEU A1949
GLY A2011
VAL A2022
 None
 1.12A 5i71A-4asiA:
undetectable		 5i71A-4asiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 6 HIS A1944
GLU A1746
ALA A1847
LEU A1846
 None
 1.10A 5igiA-4asiA:
undetectable		 5igiA-4asiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 5 HIS A1919
LEU A2077
TYR A2064
PHE A2061
 None
 1.11A 5igjA-4asiA:
undetectable		 5igjA-4asiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.11A 5ikqA-4asiA:
undetectable		 5ikqA-4asiA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.10A 5ikqB-4asiA:
undetectable		 5ikqB-4asiA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.09A 5ikrB-4asiA:
undetectable		 5ikrB-4asiA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 THR A1632
THR A1858
PRO A1639
ILE A1635
 None
 1.14A 5jhdE-4asiA:
undetectable
5jhdG-4asiA:
undetectable		 5jhdE-4asiA:
16.34
5jhdG-4asiA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 TYR A1848
TYR A2064
GLN A2065
 None
 0.90A 5jsdA-4asiA:
undetectable
5jsdB-4asiA:
undetectable		 5jsdA-4asiA:
21.68
5jsdB-4asiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 TYR A1848
TYR A2064
GLN A2065
 None
 0.91A 5jsdB-4asiA:
undetectable
5jsdC-4asiA:
undetectable		 5jsdB-4asiA:
21.68
5jsdC-4asiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 THR A1632
THR A1633
ARG A1860
SER A1881
ALA A1755
 None
 1.45A 5l5fV-4asiA:
0.0
5l5fb-4asiA:
undetectable		 5l5fV-4asiA:
14.53
5l5fb-4asiA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 THR A1632
THR A1633
ARG A1860
SER A1881
ALA A1755
 None
 1.45A 5l5fH-4asiA:
undetectable
5l5fN-4asiA:
undetectable		 5l5fH-4asiA:
14.53
5l5fN-4asiA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 THR A1632
THR A1633
ARG A1860
SER A1881
ALA A1755
 None
 1.41A 5lf3N-4asiA:
undetectable		 5lf3N-4asiA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 VAL A2265
ARG A2258
GLU A2262
TRP A2310
 None
 1.14A 5umwB-4asiA:
0.4
5umwE-4asiA:
undetectable		 5umwB-4asiA:
8.50
5umwE-4asiA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 5 ARG A1712
MET A1701
THR A1702
LEU A1669
 None
 1.42A 5z86J-4asiA:
undetectable		 5z86J-4asiA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ILE A1751
VAL A1753
ILE A1638
THR A1633
 None
 0.97A 6cduF-4asiA:
undetectable
6cduG-4asiA:
undetectable		 6cduF-4asiA:
17.91
6cduG-4asiA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 6 VAL A2117
ASN A2082
PRO A2120
ILE A2119
 None
 1.12A 6h7uA-4asiA:
undetectable		 6h7uA-4asiA:
20.10