SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4asl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4asl EPA1P
([Candida]
glabrata) 		5 / 10 PHE A 171
VAL A 169
ILE A 109
LEU A 221
PHE A 252
 None
 1.12A 1z11C-4aslA:
undetectable		 1z11C-4aslA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4asl EPA1P
([Candida]
glabrata) 		5 / 10 PHE A 171
VAL A 169
ILE A 109
LEU A 221
PHE A 252
 None
 1.11A 1z11D-4aslA:
undetectable		 1z11D-4aslA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 4asl EPA1P
([Candida]
glabrata) 		4 / 8 ASP A  69
SER A  67
TYR A  68
TYR A  88
 NA  A 304 (-3.1A)
None
None
None
 1.13A 2bteD-4aslA:
undetectable		 2bteD-4aslA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4asl EPA1P
([Candida]
glabrata) 		4 / 8 ASP A  69
SER A  67
TYR A  68
TYR A  88
 NA  A 304 (-3.1A)
None
None
None
 1.09A 2v0gA-4aslA:
undetectable		 2v0gA-4aslA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4asl EPA1P
([Candida]
glabrata) 		5 / 10 LEU A 221
ILE A 219
SER A 254
SER A  62
GLY A 147
 None
 1.06A 3ijxB-4aslA:
undetectable
3ijxD-4aslA:
undetectable		 3ijxB-4aslA:
22.80
3ijxD-4aslA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4asl EPA1P
([Candida]
glabrata) 		5 / 10 ILE A 219
SER A 254
SER A  62
GLY A 147
LEU A 221
 None
 1.18A 3ik6B-4aslA:
undetectable
3ik6E-4aslA:
undetectable		 3ik6B-4aslA:
22.80
3ik6E-4aslA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4asl EPA1P
([Candida]
glabrata) 		5 / 10 LEU A 221
ILE A 219
SER A 254
SER A  62
GLY A 147
 None
 1.05A 3ik6B-4aslA:
undetectable
3ik6E-4aslA:
undetectable		 3ik6B-4aslA:
22.80
3ik6E-4aslA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4asl EPA1P
([Candida]
glabrata) 		5 / 11 ILE A 219
SER A 254
SER A  62
GLY A 147
LEU A 221
 None
 1.07A 3iluB-4aslA:
undetectable
3iluE-4aslA:
undetectable		 3iluB-4aslA:
22.80
3iluE-4aslA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4asl EPA1P
([Candida]
glabrata) 		4 / 8 ALA A 163
ASP A 165
ILE A 109
VAL A 169
 None
GAL  A 302 ( 2.5A)
None
None
 0.71A 3nu9A-4aslA:
undetectable		 3nu9A-4aslA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4asl EPA1P
([Candida]
glabrata) 		5 / 11 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 1.00A 3w67A-4aslA:
undetectable		 3w67A-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 1.08A 3w67B-4aslA:
undetectable		 3w67B-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
ILE A 109
 None
 0.93A 3w67D-4aslA:
undetectable		 3w67D-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
VAL A 169
LEU A 221
ILE A 109
 None
 0.93A 3w67D-4aslA:
undetectable		 3w67D-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.87A 3w68A-4aslA:
undetectable		 3w68A-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.89A 3w68D-4aslA:
undetectable		 3w68D-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 234
PHE A 252
VAL A 169
PHE A 248
 None
 1.38A 4c9wA-4aslA:
undetectable		 4c9wA-4aslA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4asl EPA1P
([Candida]
glabrata) 		4 / 7 PHE A 141
LEU A 136
ALA A 100
MET A  63
 None
 1.02A 4rjdB-4aslA:
undetectable		 4rjdB-4aslA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 PHE A 248
ILE A 219
VAL A 169
LEU A 221
ILE A 109
 None
 0.82A 5mueA-4aslA:
undetectable		 5mueA-4aslA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4asl EPA1P
([Candida]
glabrata) 		5 / 12 GLY A 172
ALA A 173
ASP A 178
PRO A  52
SER A  51
 None
 0.89A 5t2zA-4aslA:
undetectable		 5t2zA-4aslA:
20.38