SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ast'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 11 TYR A 170
VAL A 217
GLY A 218
CYH A  18
LEU A 189
 None
 1.08A 2bxeA-4astA:
undetectable		 2bxeA-4astA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 TYR A 170
VAL A 217
GLY A 218
CYH A  18
LEU A 189
 None
 1.08A 2bxeB-4astA:
undetectable		 2bxeB-4astA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		4 / 7 ALA A 150
THR A 149
ALA A 152
PRO A 145
 None
 0.88A 2ql8A-4astA:
undetectable
2ql8B-4astA:
undetectable		 2ql8A-4astA:
17.31
2ql8B-4astA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		3 / 3 ILE A 332
MET A 273
ARG A 277
 None
 0.94A 4lnwA-4astA:
undetectable		 4lnwA-4astA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		3 / 3 ILE A 332
MET A 273
ARG A 277
 None
 0.95A 4lnxA-4astA:
undetectable		 4lnxA-4astA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 VAL A 203
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.38A 4olfA-4astA:
undetectable		 4olfA-4astA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 TYR A 170
VAL A 217
GLY A 218
CYH A  18
LEU A 189
 None
 1.04A 4ot2A-4astA:
undetectable		 4ot2A-4astA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 LEU A 212
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.30A 4q15A-4astA:
undetectable		 4q15A-4astA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		4 / 7 CYH A 219
ILE A 191
GLN A 193
PRO A 194
 None
 1.03A 4w5oA-4astA:
3.1		 4w5oA-4astA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 LEU A 212
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.30A 4ydqA-4astA:
undetectable		 4ydqA-4astA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 VAL A 203
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.50A 4ydqB-4astA:
undetectable		 4ydqB-4astA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		4 / 7 CYH A 219
ILE A 191
GLN A 193
PRO A 194
 None
 1.07A 4z4eA-4astA:
2.7		 4z4eA-4astA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		4 / 7 CYH A 219
ILE A 191
GLN A 193
PRO A 194
 None
 1.06A 4z4gA-4astA:
2.7		 4z4gA-4astA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		3 / 3 VAL A 203
GLN A 193
CYH A 219
 None
 0.92A 5icxC-4astA:
undetectable
5icxF-4astA:
undetectable		 5icxC-4astA:
21.52
5icxF-4astA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 MET A  13
GLU A 309
ILE A 300
ALA A 302
ALA A  52
 None
 1.23A 5kvaA-4astA:
2.9		 5kvaA-4astA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 MET A  13
GLU A 309
ILE A 300
ALA A 302
ALA A  52
 None
 1.19A 5kvaB-4astA:
undetectable		 5kvaB-4astA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 VAL A 203
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.39A 5xioA-4astA:
undetectable		 5xioA-4astA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 LEU A 212
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.28A 5xipA-4astA:
undetectable		 5xipA-4astA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 TYR A 170
VAL A 217
GLY A 218
CYH A  18
LEU A 189
 None
 1.08A 6ci6A-4astA:
undetectable		 6ci6A-4astA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4ast ALDO-KETO REDUCTASE
AKR14A1
(Escherichia
coli) 		5 / 12 VAL A 203
PRO A 194
HIS A  59
SER A  29
GLY A  31
 None
 1.42A 6mn8A-4astA:
undetectable		 6mn8A-4astA:
21.80