SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4asy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 4 ALA A 132
GLN A 211
TYR A 206
LEU A 103
 None
 1.19A 1e6wC-4asyA:
3.0		 1e6wC-4asyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  88
LEU A 106
GLY A 109
ASP A 110
ALA A   9
 None
 1.07A 2bm9F-4asyA:
undetectable		 2bm9F-4asyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  88
LEU A 106
GLY A 109
ASP A 110
ALA A   9
 None
 0.90A 2br4D-4asyA:
undetectable		 2br4D-4asyA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 11 ARG A 128
SER A 124
LEU A  45
PHE A 118
LEU A 175
 None
None
N5Y  A1294 (-3.7A)
None
None
 1.29A 2v0mA-4asyA:
undetectable		 2v0mA-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 175
ALA A  46
GLY A 123
PHE A 135
 None
 0.95A 2wq5A-4asyA:
undetectable		 2wq5A-4asyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 258
ALA A 272
TYR A  37
MET A  44
 None
 1.13A 3d91A-4asyA:
undetectable		 3d91A-4asyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 110
ILE A  51
ASN A 111
LEU A 106
THR A  42
 None
None
None
None
N5Y  A1294 (-4.5A)
 1.15A 3eeyE-4asyA:
undetectable		 3eeyE-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 110
ILE A  51
ASN A 111
LEU A 106
THR A  42
 None
None
None
None
N5Y  A1294 (-4.5A)
 1.16A 3eeyF-4asyA:
undetectable		 3eeyF-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		3 / 3 THR A 200
LYS A  25
GLU A 198
 None
 0.63A 3ijdB-4asyA:
undetectable		 3ijdB-4asyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  27
LEU A  67
GLY A  10
ALA A   9
SER A  55
 None
 1.05A 3n8xB-4asyA:
undetectable		 3n8xB-4asyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  27
LEU A  67
GLY A  10
ALA A   9
SER A  55
 None
 1.03A 3nt1A-4asyA:
undetectable		 3nt1A-4asyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  27
LEU A  67
GLY A  10
ALA A   9
SER A  55
 None
 1.02A 3nt1B-4asyA:
undetectable		 3nt1B-4asyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		6 / 12 PHE A 177
SER A 124
LEU A  45
PHE A 118
ALA A 136
GLY A 174
 None
None
N5Y  A1294 (-3.7A)
None
None
None
 1.26A 3nxuA-4asyA:
undetectable		 3nxuA-4asyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  27
LEU A  67
GLY A  10
ALA A   9
SER A  55
 None
 1.10A 3rr3C-4asyA:
undetectable		 3rr3C-4asyA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  27
LEU A  67
GLY A  10
ALA A   9
SER A  55
 None
 1.10A 3rr3D-4asyA:
undetectable		 3rr3D-4asyA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  43
ASP A  76
ILE A  99
ILE A   7
ILE A  51
 None
 1.05A 3s56B-4asyA:
undetectable		 3s56B-4asyA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 186
ILE A  99
GLY A  95
ILE A  94
LEU A  88
 None
 1.01A 3u7sA-4asyA:
undetectable		 3u7sA-4asyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 174
LEU A  43
ASP A 110
LEU A 108
ILE A   7
 None
 1.19A 3wdmB-4asyA:
undetectable		 3wdmB-4asyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 106
ILE A   6
ILE A   7
TYR A  37
ILE A  54
 None
 0.96A 3zosA-4asyA:
undetectable		 3zosA-4asyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 234
ASP A 230
ASP A 225
 None
 0.73A 4gc9A-4asyA:
undetectable		 4gc9A-4asyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 292
TYR A 283
GLU A 255
LEU A 242
 None
None
N5Y  A1294 (-3.5A)
None
 1.16A 5umwB-4asyA:
undetectable
5umwE-4asyA:
undetectable		 5umwB-4asyA:
13.31
5umwE-4asyA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 242
VAL A 292
TYR A 283
GLU A 255
 None
None
None
N5Y  A1294 (-3.5A)
 0.92A 5umwA-4asyA:
undetectable
5umwF-4asyA:
undetectable		 5umwA-4asyA:
13.31
5umwF-4asyA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		5 / 9 GLN A  90
GLN A  82
ASP A 110
GLY A 195
SER A 192
 None
 1.45A 5x7pA-4asyA:
0.4		 5x7pA-4asyA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 209
LEU A 212
ALA A 156
GLN A 181
 None
None
MES  A1296 (-3.1A)
None
 1.12A 6b89A-4asyA:
undetectable		 6b89A-4asyA:
16.73