SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4atb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		4 / 8 GLY B 260
LEU B 223
VAL B 229
MET B 266
 None
 1.21A 1gsfA-4atbB:
undetectable		 1gsfA-4atbB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		4 / 8 GLY B 260
LEU B 223
VAL B 229
MET B 266
 None
 1.21A 1gsfB-4atbB:
undetectable		 1gsfB-4atbB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		4 / 8 GLY B 260
LEU B 223
VAL B 229
MET B 266
 None
 1.21A 1gsfD-4atbB:
undetectable		 1gsfD-4atbB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus;
Mus
musculus) 		5 / 12 THR B 315
ILE B 291
GLY B 290
GLY B 288
VAL A  44
 None
 1.08A 1nv8A-4atbB:
undetectable		 1nv8A-4atbB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus;
Mus
musculus) 		5 / 12 THR B 315
ILE B 291
GLY B 290
GLY B 288
VAL A  44
 None
 1.04A 1nv8B-4atbB:
undetectable		 1nv8B-4atbB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus;
Mus
musculus) 		5 / 12 THR B 315
ILE B 291
GLY B 290
GLY B 288
VAL A  44
 None
 1.00A 1vq1B-4atbB:
undetectable		 1vq1B-4atbB:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		4 / 8 SER B 289
ALA A  40
CYH A  37
THR B 261
 None
 0.86A 3bpxA-4atbB:
undetectable
3bpxB-4atbB:
undetectable		 3bpxA-4atbB:
16.32
3bpxB-4atbB:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		5 / 12 ILE B 314
ALA B 318
GLN B 319
LEU B 279
ALA B 280
 None
 1.14A 3dzyA-4atbB:
undetectable		 3dzyA-4atbB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 12 GLY A 249
ALA A 267
LEU A 245
THR A 219
LEU A 223
 None
 1.05A 3p2kA-4atbA:
undetectable		 3p2kA-4atbA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 12 GLY A 249
ALA A 267
LEU A 245
THR A 219
LEU A 223
 None
 1.09A 3p2kB-4atbA:
undetectable		 3p2kB-4atbA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		5 / 12 LEU B 207
CYH B 116
THR B  88
ILE B  49
VAL B 113
 None
 1.19A 3sp9A-4atbB:
undetectable		 3sp9A-4atbB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 12 LEU A 193
ILE A 175
VAL A 135
LEU A 138
VAL A  97
 None
 0.97A 3w68A-4atbA:
2.8		 3w68A-4atbA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 12 LEU A 193
ILE A 175
VAL A 135
LEU A 138
VAL A  97
 None
 1.01A 3w68D-4atbA:
2.4		 3w68D-4atbA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		4 / 7 ARG B  40
THR B 363
THR B 364
VAL B  35
 None
 0.92A 4qwpB-4atbB:
undetectable		 4qwpB-4atbB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		5 / 11 ILE B 283
SER B 289
GLY B 288
ARG A 269
GLU A  38
 None
 1.33A 4xt7A-4atbB:
undetectable		 4xt7A-4atbB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 9 ARG A 327
ALA A  56
LEU A 330
GLY A 331
PHE A 211
 None
 1.42A 4y28A-4atbA:
undetectable
4y28J-4atbA:
undetectable		 4y28A-4atbA:
19.59
4y28J-4atbA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 12 LEU A 262
PHE A  34
ARG A  43
GLU A  50
SER A 322
 None
 1.36A 4ydqA-4atbA:
undetectable		 4ydqA-4atbA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 9 ILE A 329
GLY A 331
GLN A 273
LEU A 226
LEU A  64
 None
 1.44A 5fhzB-4atbA:
undetectable		 5fhzB-4atbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		4 / 6 CYH A 271
LEU A 227
HIS A 250
LEU A 248
 None
 1.20A 5hpuC-4atbA:
undetectable
5hpuD-4atbA:
undetectable		 5hpuC-4atbA:
3.85
5hpuD-4atbA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		6 / 12 ILE A 128
ILE A 175
VAL A 135
LEU A 138
VAL A  97
ILE A  99
 None
 1.03A 5mueA-4atbA:
undetectable		 5mueA-4atbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 12 ILE A 128
VAL A 135
LEU A 138
VAL A  97
ILE A  99
 None
 0.75A 5mugA-4atbA:
undetectable		 5mugA-4atbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 12 ALA A 252
LEU A 245
LEU A 248
ILE A 244
ILE A 287
 None
 1.42A 5uanB-4atbA:
undetectable		 5uanB-4atbA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		5 / 9 GLY A 139
LEU A 138
VAL A  97
ILE A 177
GLY A 163
 None
 0.96A 5vkqC-4atbA:
undetectable
5vkqD-4atbA:
undetectable		 5vkqC-4atbA:
11.57
5vkqD-4atbA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		4 / 8 PRO A 353
THR A 313
THR A 316
ALA A 336
 None
 0.91A 5x2tI-4atbA:
undetectable
5x2tJ-4atbA:
undetectable
5x2tK-4atbA:
undetectable
5x2tL-4atbA:
undetectable		 5x2tI-4atbA:
19.82
5x2tJ-4atbA:
21.14
5x2tK-4atbA:
19.82
5x2tL-4atbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2
(Mus
musculus) 		4 / 7 ALA A 137
ILE A  99
GLN A  98
VAL A  97
 None
 0.88A 6cduF-4atbA:
undetectable
6cduJ-4atbA:
undetectable		 6cduF-4atbA:
19.13
6cduJ-4atbA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		4 / 4 HIS B 305
VAL B 284
LEU B 306
ALA B 302
 None
 1.28A 6d8pB-4atbB:
undetectable		 6d8pB-4atbB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3
(Mus
musculus) 		3 / 3 THR B 356
GLU B 252
ASN B 221
 None
 0.65A 6nj9K-4atbB:
undetectable		 6nj9K-4atbB:
22.75