SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ate'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		5 / 12 PHE A 137
TYR A 169
LEU A 205
PRO A 219
TRP A 199
 None
 1.40A 2c7vB-4ateA:
undetectable		 2c7vB-4ateA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		4 / 8 ASN A  63
ARG A  59
GLU A 234
PHE A  64
 None
 0.79A 2fl5E-4ateA:
undetectable
2fl5F-4ateA:
undetectable		 2fl5E-4ateA:
18.01
2fl5F-4ateA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		3 / 3 ASP A 265
ASP A  37
ASP A  73
 CA  A1275 (-3.4A)
None
None
 0.47A 2igtA-4ateA:
undetectable		 2igtA-4ateA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		3 / 3 ASP A 265
ASP A  37
ASP A  73
 CA  A1275 (-3.4A)
None
None
 0.45A 2igtB-4ateA:
undetectable		 2igtB-4ateA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		4 / 8 LEU A 254
THR A 261
ALA A 100
ALA A 101
 None
 0.96A 3ax9B-4ateA:
undetectable		 3ax9B-4ateA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		4 / 6 SER A 128
LEU A 124
MET A 126
THR A 233
 None
CL  A1277 (-4.4A)
None
None
 1.36A 3thrB-4ateA:
undetectable		 3thrB-4ateA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		5 / 7 ASN A 253
LEU A 254
ARG A  79
GLY A 147
SER A 128
 CL  A1277 (-4.2A)
None
None
None
None
 1.15A 4cp3A-4ateA:
undetectable
4cp3B-4ateA:
undetectable		 4cp3A-4ateA:
22.88
4cp3B-4ateA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		4 / 8 TYR A 195
PHE A 119
GLY A 147
ILE A 246
 None
 0.90A 4qoiA-4ateA:
undetectable
4qoiB-4ateA:
undetectable		 4qoiA-4ateA:
21.91
4qoiB-4ateA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		3 / 3 GLU A  38
TYR A 270
GLU A 116
 None
 0.64A 4ryaA-4ateA:
undetectable		 4ryaA-4ateA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		3 / 3 ARG A 118
ASP A 265
TRP A 266
 None
CA  A1275 (-3.4A)
None
 0.29A 4xdqA-4ateA:
19.5		 4xdqA-4ateA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		3 / 3 ASP A  37
ASN A  47
PHE A  70
 None
 0.73A 5jglB-4ateA:
undetectable		 5jglB-4ateA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		3 / 3 VAL A  89
SER A  87
TRP A  97
 None
 0.93A 5jwaA-4ateA:
undetectable		 5jwaA-4ateA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		5 / 12 SER A 125
SER A 129
ILE A 230
LEU A 254
PHE A  64
 None
 1.40A 6a93A-4ateA:
undetectable		 6a93A-4ateA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		5 / 12 LEU A 254
LEU A 124
SER A 129
ARG A  83
GLY A  58
 None
CL  A1277 (-4.4A)
None
None
None
 1.01A 6b0iB-4ateA:
undetectable		 6b0iB-4ateA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		5 / 12 LEU A 254
LEU A 124
SER A 129
ARG A  83
GLY A  58
 None
CL  A1277 (-4.4A)
None
None
None
 1.00A 6b0lB-4ateA:
undetectable		 6b0lB-4ateA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4ate BETA-PORPHYRANASE A
(Zobellia
galactanivorans) 		3 / 3 LYS A 120
SER A 128
SER A 122
 None
 1.16A 6gbfA-4ateA:
undetectable		 6gbfA-4ateA:
19.69