SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4atf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 GLU A 184
HIS A 215
ASP A 173
 GAL  A1357 (-4.1A)
GAL  A1357 (-3.3A)
GAL  A1357 (-2.8A)
 0.74A 1i9gA-4atfA:
undetectable		 1i9gA-4atfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 ARG A 246
ARG A 346
ILE A 187
 None
 0.67A 1uobA-4atfA:
undetectable		 1uobA-4atfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ASP A 103
ILE A 147
LEU A 129
TYR A  86
 None
 1.04A 2ya7A-4atfA:
1.8		 2ya7A-4atfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ASP A 103
ILE A 147
LEU A 129
TYR A  86
 None
 1.05A 2ya7B-4atfA:
1.7		 2ya7B-4atfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ASP A 103
ILE A 147
LEU A 129
TYR A  86
 None
 1.05A 2ya7D-4atfA:
undetectable		 2ya7D-4atfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 4 GLY A 127
GLU A  85
ASP A  82
ASP A 126
 NA  A 500 (-4.0A)
NA  A 500 (-3.8A)
None
None
 1.17A 3mb5A-4atfA:
undetectable		 3mb5A-4atfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ILE A 347
ILE A 261
GLY A 248
VAL A 342
 None
 0.92A 3n3iA-4atfA:
undetectable		 3n3iA-4atfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		5 / 12 THR A 169
GLY A 192
ASP A 194
SER A 207
GLU A 197
 None
 1.36A 3tkaA-4atfA:
undetectable		 3tkaA-4atfA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 TRP A 109
TRP A 117
THR A 115
 GAL  A1355 (-3.6A)
None
None
 1.31A 4bboB-4atfA:
undetectable		 4bboB-4atfA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		6 / 12 GLY A 248
ILE A  63
ILE A 347
VAL A 342
VAL A 153
ILE A  80
 None
 1.50A 4q5mA-4atfA:
undetectable		 4q5mA-4atfA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 ARG A 162
ASP A 343
TRP A 344
 None
NA  A 500 (-3.4A)
None
 0.30A 4xdqA-4atfA:
18.8		 4xdqA-4atfA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 GLU A 184
HIS A 215
ASP A 173
 GAL  A1357 (-4.1A)
GAL  A1357 (-3.3A)
GAL  A1357 (-2.8A)
 0.86A 5c0oG-4atfA:
undetectable		 5c0oG-4atfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4atf BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 TYR A 225
ASP A 224
GLN A 226
 None
None
AAL  A1358 (-3.4A)
 0.94A 6g1pA-4atfA:
undetectable		 6g1pA-4atfA:
21.29