SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4atq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 430
ALA A 358
LEU A 362
ALA A 366
ILE A 380
 None
 0.75A 1fk6A-4atqA:
undetectable		 1fk6A-4atqA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 10 ALA A 228
VAL A 155
ILE A 222
GLY A 223
GLY A 224
 None
 0.91A 1k6cA-4atqA:
undetectable		 1k6cA-4atqA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.83A 1p7lD-4atqA:
undetectable		 1p7lD-4atqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.83A 1p7lC-4atqA:
undetectable		 1p7lC-4atqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.82A 1rg9A-4atqA:
undetectable		 1rg9A-4atqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.83A 1rg9D-4atqA:
undetectable		 1rg9D-4atqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.84A 1rg9C-4atqA:
undetectable		 1rg9C-4atqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		6 / 12 TYR A 325
ALA A 331
GLY A 327
ILE A 297
SER A 304
ALA A 334
 None
 1.47A 1ve3A-4atqA:
undetectable		 1ve3A-4atqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		6 / 12 TYR A 325
ALA A 331
GLY A 327
ILE A 297
SER A 304
ALA A 334
 None
 1.35A 1ve3B-4atqA:
undetectable		 1ve3B-4atqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 11 GLY A 240
GLY A 237
ILE A 418
LEU A 430
ALA A 388
 None
 0.89A 1x7pA-4atqA:
undetectable
1x7pB-4atqA:
undetectable		 1x7pA-4atqA:
21.04
1x7pB-4atqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 294
GLY A 271
GLY A  70
LEU A 431
LEU A 419
 PLP  A1456 ( 4.6A)
None
None
None
None
 1.06A 2hw2A-4atqA:
undetectable		 2hw2A-4atqA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		3 / 3 ASP A  54
ASP A  68
ASP A  82
 None
 0.73A 2igtB-4atqA:
2.1		 2igtB-4atqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 6 LEU A 441
ILE A 436
ARG A 274
VAL A 376
 None
 1.03A 2ygoA-4atqA:
undetectable		 2ygoA-4atqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 10 THR A  76
SER A  77
SER A  71
GLY A  72
GLY A  70
 None
 1.49A 3ixlA-4atqA:
undetectable		 3ixlA-4atqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 9 VAL A 268
LEU A 167
ALA A 137
GLU A 139
THR A 165
 PLP  A1456 (-4.2A)
None
None
None
None
 1.00A 3mdvA-4atqA:
undetectable		 3mdvA-4atqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 268
LEU A 167
ALA A 137
GLU A 139
THR A 165
 PLP  A1456 (-4.2A)
None
None
None
None
 1.00A 3mdvB-4atqA:
undetectable		 3mdvB-4atqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 261
ALA A 145
ARG A 191
ILE A 230
THR A 149
 None
 1.15A 3ql3A-4atqA:
undetectable		 3ql3A-4atqA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A  69
ILE A 389
ILE A 442
ARG A 363
ALA A 358
 None
 1.36A 3uj7A-4atqA:
undetectable		 3uj7A-4atqA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 7 GLU A 200
ILE A 205
VAL A 155
PHE A 248
 None
 1.08A 4a97H-4atqA:
undetectable		 4a97H-4atqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 7 GLY A 207
THR A 206
ILE A 205
THR A 216
 None
 0.87A 4acaC-4atqA:
2.7		 4acaC-4atqA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 11 GLY A 134
VAL A 138
GLU A 139
SER A 133
VAL A 268
 PLP  A1456 (-3.3A)
None
None
PLP  A1456 (-3.8A)
PLP  A1456 (-4.2A)
 1.29A 4danA-4atqA:
undetectable		 4danA-4atqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		3 / 3 PHE A 198
TYR A 424
TYR A 196
 None
 0.98A 4ffwA-4atqA:
undetectable		 4ffwA-4atqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.91A 4kttD-4atqA:
undetectable		 4kttD-4atqA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 7 GLU A 233
ARG A 381
GLY A 240
GLY A 237
 PLP  A1456 (-3.7A)
None
None
None
 0.87A 4rdxA-4atqA:
undetectable		 4rdxA-4atqA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		6 / 11 GLU A 446
ALA A 449
LEU A 445
LEU A 441
LEU A  69
LEU A 430
 None
 1.35A 4wg0C-4atqA:
undetectable
4wg0D-4atqA:
undetectable
4wg0E-4atqA:
undetectable		 4wg0C-4atqA:
2.51
4wg0D-4atqA:
2.51
4wg0E-4atqA:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		6 / 11 GLU A 446
ALA A 449
LEU A 445
LEU A 441
LEU A  69
LEU A 430
 None
 1.36A 4wg0E-4atqA:
undetectable
4wg0F-4atqA:
undetectable
4wg0G-4atqA:
undetectable		 4wg0E-4atqA:
2.51
4wg0F-4atqA:
2.51
4wg0G-4atqA:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ILE A 230
ALA A 256
ALA A 211
ILE A 215
 None
 0.70A 5mvmA-4atqA:
undetectable
5mvmB-4atqA:
undetectable		 5mvmA-4atqA:
9.15
5mvmB-4atqA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		3 / 3 THR A 324
HIS A  98
ASN A 328
 None
 0.67A 5n4tA-4atqA:
1.7		 5n4tA-4atqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 440
PRO A 433
ASP A  54
GLY A  79
TYR A  10
 None
 1.16A 5nnaC-4atqA:
undetectable		 5nnaC-4atqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A  80
ASP A  60
ILE A  58
ILE A 417
 None
 0.90A 5t8sA-4atqA:
undetectable		 5t8sA-4atqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4atq 4-AMINOBUTYRATE
TRANSAMINASE
(Paenarthrobacter
aurescens) 		5 / 12 MET A 386
ALA A  74
GLY A 296
SER A  77
LEU A 434
 None
 1.32A 5vlmF-4atqA:
undetectable		 5vlmF-4atqA:
18.34