SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4atw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 412
GLY A 307
ILE A 353
GLY A 302
 None
 0.80A 11gsB-4atwA:
undetectable		 11gsB-4atwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 8 THR A 195
THR A 269
VAL A 275
ASP A 230
 None
 1.16A 1uyuB-4atwA:
undetectable		 1uyuB-4atwA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 5 GLY A 274
PRO A 320
VAL A 319
ILE A 318
 None
 0.99A 2aoiA-4atwA:
undetectable		 2aoiA-4atwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 12 VAL A 260
LEU A 263
VAL A 267
THR A 195
GLY A 211
 None
 1.13A 2cbrA-4atwA:
undetectable		 2cbrA-4atwA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 11 HIS A 469
PHE A 467
ILE A 479
THR A 470
VAL A 424
 None
 1.47A 2gl0B-4atwA:
undetectable
2gl0C-4atwA:
undetectable		 2gl0B-4atwA:
16.74
2gl0C-4atwA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 479
THR A 470
VAL A 424
HIS A 469
PHE A 467
 None
 1.45A 2gl0A-4atwA:
undetectable
2gl0C-4atwA:
undetectable		 2gl0A-4atwA:
16.74
2gl0C-4atwA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 469
PHE A 467
ILE A 479
THR A 470
VAL A 424
 None
 1.48A 2gl0D-4atwA:
undetectable
2gl0E-4atwA:
undetectable		 2gl0D-4atwA:
16.74
2gl0E-4atwA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 11 HIS A 469
PHE A 467
ILE A 479
THR A 470
VAL A 424
 None
 1.48A 2gl0E-4atwA:
undetectable
2gl0F-4atwA:
undetectable		 2gl0E-4atwA:
16.74
2gl0F-4atwA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 4 ILE A 334
GLN A 326
ILE A  60
LEU A 293
 None
 1.21A 3dzyD-4atwA:
undetectable		 3dzyD-4atwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 10 ALA A 394
ALA A 408
PHE A 471
VAL A 463
ILE A 461
 None
 1.13A 3falA-4atwA:
undetectable		 3falA-4atwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 11 TYR A 297
ALA A 325
VAL A 346
LEU A 309
THR A 249
 None
 1.41A 3jwqB-4atwA:
undetectable
3jwqC-4atwA:
undetectable		 3jwqB-4atwA:
21.16
3jwqC-4atwA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 11 ARG A  66
ASN A  64
LEU A 324
LEU A 312
LEU A 309
 None
 1.25A 3ndvA-4atwA:
undetectable
3ndvB-4atwA:
undetectable		 3ndvA-4atwA:
22.00
3ndvB-4atwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A 312
LEU A 309
ARG A  66
ASN A  64
LEU A 324
 None
 1.28A 3ndvA-4atwA:
undetectable
3ndvB-4atwA:
undetectable		 3ndvA-4atwA:
22.00
3ndvB-4atwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 11 ARG A  66
ASN A  64
LEU A 324
LEU A 312
LEU A 309
 None
 1.27A 3ndvC-4atwA:
undetectable
3ndvD-4atwA:
undetectable		 3ndvC-4atwA:
22.00
3ndvD-4atwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A 312
LEU A 309
ARG A  66
ASN A  64
LEU A 324
 None
 1.25A 3ndvC-4atwA:
undetectable
3ndvD-4atwA:
undetectable		 3ndvC-4atwA:
22.00
3ndvD-4atwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A  35
GLY A  34
ILE A 342
MET A 448
VAL A  53
 None
 0.97A 3nk7A-4atwA:
undetectable		 3nk7A-4atwA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 12 VAL A 328
ILE A 116
PHE A 104
TYR A 112
TYR A  33
 None
 1.41A 3q5pA-4atwA:
undetectable		 3q5pA-4atwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 301
GLY A 239
TYR A 297
GLU A 295
 None
 1.41A 3w9tA-4atwA:
undetectable		 3w9tA-4atwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 301
GLY A 239
TYR A 297
GLU A 295
 None
 1.40A 3w9tC-4atwA:
undetectable		 3w9tC-4atwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 301
GLY A 239
TYR A 297
GLU A 295
 None
 1.41A 3w9tD-4atwA:
undetectable		 3w9tD-4atwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 301
GLY A 239
TYR A 297
GLU A 295
 None
 1.40A 3w9tG-4atwA:
undetectable		 3w9tG-4atwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 8 PRO A 320
SER A  17
VAL A 275
GLY A 274
 None
 0.97A 4mk4A-4atwA:
undetectable		 4mk4A-4atwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 7 VAL A 420
LEU A 392
SER A 368
GLU A 369
 None
 1.10A 4zphA-4atwA:
undetectable
4zphB-4atwA:
undetectable		 4zphA-4atwA:
23.32
4zphB-4atwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 6 TYR A 174
ASP A 213
PHE A 236
TYR A 234
 None
 1.45A 5e2iA-4atwA:
undetectable		 5e2iA-4atwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 9 GLU A 281
GLU A 172
VAL A 210
GLY A  69
GLN A 178
 None
 1.44A 5ksnA-4atwA:
undetectable		 5ksnA-4atwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 169
GLY A 168
ALA A 209
ALA A 191
VAL A 228
 None
 1.05A 5n0oB-4atwA:
undetectable		 5n0oB-4atwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 169
GLY A 168
ALA A 209
ALA A 191
VAL A 228
 None
 1.01A 5n0tB-4atwA:
undetectable		 5n0tB-4atwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN
(Thermotoga
maritima) 		4 / 7 VAL A 454
PRO A 345
GLY A 302
TYR A 297
 None
 1.00A 5x80C-4atwA:
undetectable
5x80D-4atwA:
undetectable		 5x80C-4atwA:
14.08
5x80D-4atwA:
14.08