SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A  58
ALA A  34
PRO A  54
THR A 343
ILE A 140
 None
 1.13A 1mx8A-4atyA:
undetectable		 1mx8A-4atyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 5 ALA A 212
TYR A 175
ILE A 307
ASP A 173
 None
 1.19A 1upfA-4atyA:
undetectable		 1upfA-4atyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 THR A 343
GLY A 337
VAL A  57
ASP A  95
ILE A  94
 None
 1.05A 2b25B-4atyA:
undetectable		 2b25B-4atyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 305
ILE A 307
ALA A 303
VAL A 347
MET A 220
 None
 1.20A 2qo4A-4atyA:
undetectable		 2qo4A-4atyA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 305
ILE A 307
ALA A 303
VAL A 347
MET A 220
 None
 1.21A 2qo6A-4atyA:
undetectable		 2qo6A-4atyA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 5 HIS A 291
ILE A 185
HIS A 187
LEU A 176
 None
 1.23A 3qpkA-4atyA:
undetectable		 3qpkA-4atyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 10 TYR A  68
ILE A  65
ASN A  23
ILE A  19
ALA A  30
 None
 1.24A 3u6tA-4atyA:
undetectable		 3u6tA-4atyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 TYR A 159
GLY A 319
GLY A 317
LEU A 335
ILE A  25
 None
 1.12A 4qtuB-4atyA:
2.6		 4qtuB-4atyA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		4 / 7 ILE A 149
HIS A 144
LEU A 121
GLY A 158
 None
 1.04A 4z69A-4atyA:
undetectable		 4z69A-4atyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 317
THR A 120
GLY A 117
GLY A 321
ILE A  29
 None
 0.93A 5tuiB-4atyA:
2.9		 5tuiB-4atyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 12 VAL A 124
ALA A 130
PRO A  27
TYR A 159
ALA A 127
 None
 1.35A 5tzoA-4atyA:
undetectable		 5tzoA-4atyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE
(Paraburkholderia
xenovorans) 		5 / 10 ALA A 254
LEU A 229
VAL A 264
VAL A 283
ALA A 213
 None
 1.23A 6h1lA-4atyA:
undetectable		 6h1lA-4atyA:
21.97