SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4auk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
3 / 3 TRP A 225
ARG A 258
THR A 226
None
0.76A 1df7A-4aukA:
1.9
1df7A-4aukA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
4 / 6 LEU A 137
VAL A 148
VAL A  90
GLN A  94
None
0.89A 1e7aB-4aukA:
undetectable
1e7aB-4aukA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 11 ILE A 336
ALA A 334
ARG A 354
LEU A 305
ALA A 286
None
None
TLA  A1363 (-2.8A)
None
None
1.25A 1n4hA-4aukA:
undetectable
1n4hA-4aukA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
4 / 5 PHE A  61
ARG A 339
ILE A  20
GLU A  19
None
EDO  A1368 (-3.5A)
None
None
1.48A 1oniG-4aukA:
1.1
1oniH-4aukA:
undetectable
1oniG-4aukA:
15.63
1oniH-4aukA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 TYR A 227
ALA A 245
GLY A 223
SER A 238
SER A 247
EDO  A1370 ( 4.7A)
None
None
None
EDO  A1370 (-3.9A)
1.13A 1ve3A-4aukA:
10.7
1ve3A-4aukA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
3 / 3 HIS A 197
ASP A 206
ASN A 211
None
0.86A 1wg8B-4aukA:
12.8
1wg8B-4aukA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 SER A 188
GLY A 219
GLY A 223
TRP A 225
MET A 278
None
EDO  A1373 (-3.8A)
None
None
None
0.98A 2nyuA-4aukA:
15.2
2nyuA-4aukA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
4 / 4 PRO A 222
ASP A 240
ASP A 260
ASP A 277
None
EDO  A1373 (-3.1A)
None
None
0.88A 2nyuA-4aukA:
15.2
2nyuA-4aukA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 SER A 188
GLY A 219
GLY A 223
TRP A 225
MET A 278
None
EDO  A1373 (-3.8A)
None
None
None
0.95A 2nyuB-4aukA:
15.6
2nyuB-4aukA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
4 / 5 PRO A 222
ASP A 240
ASP A 260
ASP A 277
None
EDO  A1373 (-3.1A)
None
None
0.96A 2nyuB-4aukA:
15.6
2nyuB-4aukA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.71A 2pxcA-4aukA:
12.9
2pxcA-4aukA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
3 / 3 ARG A 132
VAL A 105
THR A 124
None
EDO  A1377 (-3.8A)
EDO  A1377 (-3.1A)
0.81A 3cyxA-4aukA:
undetectable
3cyxA-4aukA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
PRO A 222
GLY A 223
GLY A 224
TRP A 225
EDO  A1373 (-3.8A)
None
None
None
None
0.50A 3douA-4aukA:
14.7
3douA-4aukA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
PHE A 262
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.65A 3eluA-4aukA:
13.2
3eluA-4aukA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
PHE A 262
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.66A 3elwA-4aukA:
12.9
3elwA-4aukA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 SER A 186
GLY A 219
GLY A 224
TRP A 225
ASP A 277
None
EDO  A1373 (-3.8A)
None
None
None
0.69A 3gczA-4aukA:
13.7
3gczA-4aukA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 11 ALA A  24
LEU A  64
LEU A   6
VAL A   4
ASN A 167
None
None
None
None
PEG  A1364 (-4.0A)
1.27A 3jw5A-4aukA:
undetectable
3jw5A-4aukA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.75A 3p97A-4aukA:
12.2
3p97A-4aukA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
12 / 12 SER A 186
GLY A 219
CYH A 221
PRO A 222
GLY A 223
GLY A 224
TRP A 225
ASP A 240
ASP A 260
ASP A 277
MET A 278
VAL A 279
None
EDO  A1373 (-3.8A)
EDO  A1373 (-4.5A)
None
None
None
None
EDO  A1373 (-3.1A)
None
None
None
None
0.54A 4b17A-4aukA:
55.8
4b17A-4aukA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
6 / 12 SER A 186
GLY A 219
GLY A 223
ASP A 277
MET A 278
VAL A 279
None
EDO  A1373 (-3.8A)
None
None
None
None
1.25A 4b17A-4aukA:
55.8
4b17A-4aukA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
7 / 12 SER A 188
GLY A 219
CYH A 221
GLY A 223
GLY A 224
ASP A 240
ASP A 260
None
EDO  A1373 (-3.8A)
EDO  A1373 (-4.5A)
None
None
EDO  A1373 (-3.1A)
None
1.20A 4b17A-4aukA:
55.8
4b17A-4aukA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.80A 4ctjA-4aukA:
12.5
4ctjA-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.74A 4ctkA-4aukA:
12.5
4ctkA-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 SER A 186
GLY A 219
GLY A 224
TRP A 225
ASP A 277
None
EDO  A1373 (-3.8A)
None
None
None
0.71A 4ctkC-4aukA:
12.6
4ctkC-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
4 / 4 ALA A 283
ALA A 286
ALA A 287
ALA A 290
EDO  A1375 (-3.1A)
None
None
None
0.09A 4oadA-4aukA:
undetectable
4oadA-4aukA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
4 / 4 ALA A 283
ALA A 286
ALA A 287
ALA A 290
EDO  A1375 (-3.1A)
None
None
None
0.07A 4oaeA-4aukA:
undetectable
4oaeA-4aukA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.77A 5e9qA-4aukA:
12.5
5e9qA-4aukA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.73A 5e9qC-4aukA:
12.6
5e9qC-4aukA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 SER A 186
GLY A 219
GLY A 224
TRP A 225
ASP A 277
None
EDO  A1373 (-3.8A)
None
None
None
0.75A 5ec8A-4aukA:
12.1
5ec8A-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.76A 5ehgA-4aukA:
12.5
5ehgA-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.78A 5eifA-4aukA:
12.6
5eifA-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.77A 5eifC-4aukA:
12.6
5eifC-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.73A 5eiwC-4aukA:
12.6
5eiwC-4aukA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
3 / 3 ARG A   9
HIS A 343
ARG A 345
None
0.70A 5iaoC-4aukA:
2.3
5iaoC-4aukA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
3 / 3 ARG A   9
HIS A 343
ARG A 345
None
0.71A 5iaoF-4aukA:
2.6
5iaoF-4aukA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.77A 5ikmA-4aukA:
11.7
5ikmA-4aukA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
4 / 8 HIS A 149
LEU A 137
GLY A 100
VAL A 147
None
1.02A 5m8rC-4aukA:
undetectable
5m8rC-4aukA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.79A 5njvB-4aukA:
12.8
5njvB-4aukA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 PRO A 222
ASP A 240
ASP A 260
GLY A 261
ASP A 277
None
EDO  A1373 (-3.1A)
None
None
None
0.98A 5wwsB-4aukA:
9.5
5wwsB-4aukA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.78A 5wz1A-4aukA:
12.8
5wz1A-4aukA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.80A 5wz1C-4aukA:
12.7
5wz1C-4aukA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.77A 5wz1D-4aukA:
12.2
5wz1D-4aukA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.76A 5wz1F-4aukA:
12.8
5wz1F-4aukA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.78A 5wz1G-4aukA:
12.7
5wz1G-4aukA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 GLY A 219
GLY A 224
TRP A 225
ASP A 260
ASP A 277
EDO  A1373 (-3.8A)
None
None
None
None
0.79A 5wz1H-4aukA:
12.5
5wz1H-4aukA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 LEU A   7
VAL A   5
VAL A  73
GLY A 161
LEU A 127
None
1.23A 5x24A-4aukA:
undetectable
5x24A-4aukA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
5 / 12 PHE A 151
ALA A 108
PHE A  61
THR A 349
LEU A 341
None
1.32A 6aycA-4aukA:
undetectable
6aycA-4aukA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli)
3 / 3 HIS A 351
ARG A 208
ILE A 200
None
0.74A 6fgdA-4aukA:
undetectable
6fgdA-4aukA:
23.09