SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4auo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 7 SER A 299
GLY A 214
THR A 222
ILE A 213
 None
 0.84A 1gtnC-4auoA:
undetectable
1gtnD-4auoA:
undetectable		 1gtnC-4auoA:
14.14
1gtnD-4auoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 6 SER A 299
GLY A 214
THR A 222
ILE A 213
 None
 0.92A 1gtnD-4auoA:
undetectable
1gtnE-4auoA:
undetectable		 1gtnD-4auoA:
14.14
1gtnE-4auoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 7 SER A 299
GLY A 214
THR A 222
ILE A 213
 None
 0.88A 1gtnF-4auoA:
undetectable
1gtnG-4auoA:
undetectable		 1gtnF-4auoA:
14.14
1gtnG-4auoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 7 SER A 299
GLY A 214
THR A 222
ILE A 213
 None
 0.86A 1gtnJ-4auoA:
undetectable
1gtnK-4auoA:
undetectable		 1gtnJ-4auoA:
14.14
1gtnK-4auoA:
14.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.12A 1os2A-4auoA:
28.3		 1os2A-4auoA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.14A 1y93A-4auoA:
27.8		 1y93A-4auoA:
55.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 8 LEU A 162
HIS A 199
HIS A 203
HIS A 209
 None
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.29A 2jihB-4auoA:
9.9		 2jihB-4auoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 12 GLU A 383
TYR A 313
THR A 269
PHE A 324
TYR A 341
 None
 1.18A 2mjiA-4auoA:
undetectable		 2mjiA-4auoA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.33A 2ow9A-4auoA:
28.0		 2ow9A-4auoA:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 HIS A 199
HIS A 203
HIS A 209
 ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.26A 2ozrF-4auoA:
27.5		 2ozrF-4auoA:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 11 LEU A 216
ALA A 200
PHE A 178
ALA A 163
TYR A 221
 None
 1.38A 3bszF-4auoA:
undetectable		 3bszF-4auoA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 ILE A 234
SER A 244
SER A 123
 None
 0.61A 3iltH-4auoA:
undetectable		 3iltH-4auoA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.29A 3likA-4auoA:
28.0		 3likA-4auoA:
55.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.25A 3lkaA-4auoA:
28.0		 3lkaA-4auoA:
57.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 8 PHE A 411
ALA A 409
PHE A 445
ALA A 441
 None
 1.00A 3t3sF-4auoA:
undetectable		 3t3sF-4auoA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.35A 4a7bA-4auoA:
28.3		 4a7bA-4auoA:
33.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 GLN A 238
THR A 126
LEU A 216
LEU A 229
 None
 1.11A 4lvcB-4auoA:
undetectable		 4lvcB-4auoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 12 LEU A 263
THR A 264
ASP A 266
ASP A 408
GLY A 422
 None
 1.10A 4qb9E-4auoA:
undetectable		 4qb9E-4auoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 GLN A 238
THR A 126
LEU A 216
LEU A 229
 None
 1.10A 5m5kB-4auoA:
undetectable		 5m5kB-4auoA:
21.19