SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aur'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 4aur LEOA
(Escherichia
coli) 		4 / 4 VAL A 321
PHE A 381
SER A 385
VAL A 388
 None
 1.34A 1e7cA-4aurA:
1.6		 1e7cA-4aurA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4aur LEOA
(Escherichia
coli) 		3 / 3 ARG A 232
TYR A 236
LYS A 240
 None
 1.06A 1uujB-4aurA:
1.6		 1uujB-4aurA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4aur LEOA
(Escherichia
coli) 		5 / 12 LEU A 206
PHE A 174
ILE A 141
ILE A 135
ILE A 158
 None
 1.47A 2efjA-4aurA:
undetectable		 2efjA-4aurA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4aur LEOA
(Escherichia
coli) 		4 / 5 LEU A 100
ILE A 106
ILE A  70
ALA A  71
 None
 0.77A 2i2zA-4aurA:
2.8		 2i2zA-4aurA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4aur LEOA
(Escherichia
coli) 		4 / 4 LEU A 100
ILE A 106
ILE A  70
ALA A  71
 None
 0.72A 2i30A-4aurA:
undetectable		 2i30A-4aurA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4aur LEOA
(Escherichia
coli) 		5 / 10 LEU A 556
ALA A 421
ILE A 428
LEU A 433
PHE A 415
 None
 1.21A 3fl9A-4aurA:
undetectable		 3fl9A-4aurA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4aur LEOA
(Escherichia
coli) 		4 / 7 VAL A 107
LEU A 112
MET A  85
ILE A  94
 None
 0.94A 3gp0A-4aurA:
undetectable		 3gp0A-4aurA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4aur LEOA
(Escherichia
coli) 		5 / 12 THR A 435
THR A 436
ILE A 549
ILE A 428
LEU A 542
 None
 1.26A 3gwxA-4aurA:
undetectable		 3gwxA-4aurA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4aur LEOA
(Escherichia
coli) 		3 / 3 ILE A 314
SER A 389
SER A 393
 None
 0.65A 3iltH-4aurA:
undetectable		 3iltH-4aurA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4aur LEOA
(Escherichia
coli) 		4 / 6 ALA A  14
ILE A  49
VAL A 268
HIS A 139
 None
 1.22A 3nneG-4aurA:
undetectable		 3nneG-4aurA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4aur LEOA
(Escherichia
coli) 		5 / 12 LEU A 288
ALA A 289
LEU A 418
GLY A  32
LEU A  28
 None
 1.03A 3olsA-4aurA:
undetectable		 3olsA-4aurA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4aur LEOA
(Escherichia
coli) 		4 / 4 LYS A 203
GLN A 219
ILE A 260
LEU A 253
 None
 1.45A 3qt0A-4aurA:
undetectable		 3qt0A-4aurA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4aur LEOA
(Escherichia
coli) 		5 / 10 LEU A 418
ILE A 559
GLY A 420
GLY A  32
SER A 557
 None
 0.98A 4fakA-4aurA:
undetectable		 4fakA-4aurA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4aur LEOA
(Escherichia
coli) 		4 / 7 ILE A 158
ASP A  90
GLY A 111
PHE A 113
 None
 0.87A 4iqqB-4aurA:
undetectable		 4iqqB-4aurA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4aur LEOA
(Escherichia
coli) 		4 / 5 ASP A  38
VAL A 277
ASP A 276
GLY A 274
 None
 1.19A 4xp6A-4aurA:
undetectable		 4xp6A-4aurA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4aur LEOA
(Escherichia
coli) 		4 / 7 ILE A 158
ASP A  90
GLY A 111
PHE A 113
 None
 0.86A 5h3aA-4aurA:
undetectable		 5h3aA-4aurA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4aur LEOA
(Escherichia
coli) 		4 / 7 ILE A 158
ASP A  90
GLY A 111
PHE A 113
 None
 0.89A 5nooB-4aurA:
undetectable		 5nooB-4aurA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4aur LEOA
(Escherichia
coli) 		4 / 7 PHE A 354
ASP A 350
LEU A 346
SER A 341
 None
 0.96A 5uxcA-4aurA:
2.4		 5uxcA-4aurA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4aur LEOA
(Escherichia
coli) 		5 / 12 LEU A 261
CYH A 104
GLN A 103
ILE A  83
ILE A  56
 None
 1.08A 5y2tB-4aurA:
undetectable		 5y2tB-4aurA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4aur LEOA
(Escherichia
coli) 		5 / 9 LEU A 400
SER A 401
THR A 397
ILE A 444
VAL A 538
 None
 1.26A 6ef6A-4aurA:
undetectable		 6ef6A-4aurA:
22.13