SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 150
VAL A 153
SER A 148
ASP A 137
ILE A 134
 None
 1.18A 1pk9C-4autA:
undetectable		 1pk9C-4autA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  48
ALA A  51
ILE A  79
GLY A 189
LEU A 159
 None
 1.00A 1qknA-4autA:
undetectable		 1qknA-4autA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 387
GLY A 150
ASN A 151
GLY A 147
 None
 1.07A 1zlqA-4autA:
undetectable		 1zlqA-4autA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A 158
VAL A 165
VAL A  47
ILE A  43
VAL A  44
 None
 1.00A 2l8mA-4autA:
undetectable		 2l8mA-4autA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A  97
VAL A 103
ASP A 100
VAL A 130
 None
 1.03A 2qbnA-4autA:
undetectable		 2qbnA-4autA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 PHE A 457
PHE A  14
VAL A  42
ILE A  43
PRO A  40
 None
 1.31A 2vcdA-4autA:
undetectable		 2vcdA-4autA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLN A  72
PHE A 457
ALA A 458
GLY A  74
ARG A 463
 None
 1.45A 3aobC-4autA:
3.4		 3aobC-4autA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 129
VAL A 128
VAL A  97
LEU A 117
ILE A 196
 FAD  A 600 (-2.9A)
FAD  A 600 (-3.6A)
None
None
None
 1.18A 3elzC-4autA:
undetectable		 3elzC-4autA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 196
GLY A 140
PRO A 387
VAL A 182
LEU A 105
 None
FAD  A 600 ( 4.8A)
None
None
None
 1.26A 3elzC-4autA:
undetectable		 3elzC-4autA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 THR A 213
GLY A 248
PHE A 373
LEU A 216
ILE A 220
 None
 1.13A 3kvrA-4autA:
undetectable		 3kvrA-4autA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 133
GLY A 184
GLY A 186
PRO A 123
LEU A 105
 None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.6A)
None
 1.04A 3m6vA-4autA:
undetectable		 3m6vA-4autA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 133
GLY A 184
GLY A 186
PRO A 123
LEU A 105
 None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.6A)
None
 1.05A 3m6wA-4autA:
undetectable		 3m6wA-4autA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 150
VAL A 153
SER A 148
ASP A 137
ILE A 134
 None
 1.21A 3uawA-4autA:
undetectable		 3uawA-4autA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 163
ALA A 161
ALA A  50
VAL A 456
VAL A  44
 None
 1.19A 4df3A-4autA:
undetectable		 4df3A-4autA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 163
ALA A 161
ALA A  50
VAL A 456
VAL A  44
 None
 1.18A 4df3B-4autA:
undetectable		 4df3B-4autA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A 153
ARG A 193
ILE A 191
ALA A 101
 None
None
FAD  A 600 (-3.7A)
FAD  A 600 (-3.5A)
 0.91A 4lv9B-4autA:
undetectable		 4lv9B-4autA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 392
PHE A 376
PHE A 344
TYR A 438
 None
 1.33A 4v2zC-4autA:
undetectable		 4v2zC-4autA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 SER A 234
TYR A 231
PHE A 222
GLU A 228
 None
 1.44A 4xzkA-4autA:
undetectable		 4xzkA-4autA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 458
GLY A  55
GLY A  57
GLY A  75
ALA A  51
 None
 1.02A 5c0oE-4autA:
undetectable		 5c0oE-4autA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 150
LEU A 108
GLY A 116
THR A 201
MET A 198
 None
 1.18A 5eskA-4autA:
undetectable		 5eskA-4autA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 385
GLY A 150
ASN A 151
ILE A 138
 None
None
None
FAD  A 600 (-3.7A)
 1.02A 5j4nA-4autA:
undetectable		 5j4nA-4autA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A 450
THR A 181
ASP A 137
ASP A 176
 None
 1.43A 5vimA-4autA:
undetectable		 5vimA-4autA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A 450
THR A 181
ASP A 137
ASP A 176
 None
 1.44A 5vimB-4autA:
undetectable		 5vimB-4autA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 421
GLU A 416
VAL A 414
THR A 408
ARG A 412
 None
 1.41A 5xipD-4autA:
undetectable		 5xipD-4autA:
22.16