SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4av2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ

(Neisseria
meningitidis)
3 / 3 ASP A 463
LYS A 504
ARG A 503
None
1.13A 1ra8A-4av2A:
undetectable
1ra8A-4av2A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4av2 PILP PROTEIN
(Neisseria
meningitidis)
5 / 10 ARG M  96
ILE M 111
GLY M 127
ARG M 132
ILE M 133
None
1.47A 3adsA-4av2M:
undetectable
3adsA-4av2M:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4av2 PILP PROTEIN
(Neisseria
meningitidis)
5 / 12 LEU M 143
GLY M 109
SER M 108
ASN M 124
LEU M 126
None
0.98A 3cjtO-4av2M:
undetectable
3cjtO-4av2M:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ

(Neisseria
meningitidis)
4 / 8 ARG A 402
ASN A 379
GLU A 356
ILE A 357
None
1.01A 4d33A-4av2A:
undetectable
4d33A-4av2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ

(Neisseria
meningitidis)
4 / 7 ARG A 402
ASN A 379
GLU A 356
ILE A 357
None
1.10A 4d33B-4av2A:
undetectable
4d33B-4av2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ

(Neisseria
meningitidis)
4 / 7 ARG A 402
ASN A 379
GLU A 356
ILE A 357
None
1.10A 4d39B-4av2A:
undetectable
4d39B-4av2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
4av2 PILP PROTEIN
(Neisseria
meningitidis)
4 / 8 LEU M 143
LEU M 146
TYR M 125
MET M  95
None
1.18A 5hbsA-4av2M:
undetectable
5hbsA-4av2M:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ
PILP PROTEIN

(Neisseria
meningitidis;
Neisseria
meningitidis)
3 / 3 LYS M 106
LYS A 387
SER A 349
None
1.39A 5odiA-4av2M:
undetectable
5odiA-4av2M:
14.96