SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4avc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 SER A  35
ALA A  34
GLY A  28
ALA A  33
THR A 120
 None
 1.29A 1gtnI-4avcA:
undetectable
1gtnJ-4avcA:
undetectable		 1gtnI-4avcA:
11.71
1gtnJ-4avcA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  28
ALA A  33
THR A 120
SER A  35
ALA A  34
 None
 1.22A 1gtnO-4avcA:
undetectable
1gtnP-4avcA:
undetectable		 1gtnO-4avcA:
11.71
1gtnP-4avcA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  28
ALA A  33
THR A 120
SER A  35
ALA A  34
 None
 1.24A 1gtnQ-4avcA:
undetectable
1gtnR-4avcA:
undetectable		 1gtnQ-4avcA:
11.71
1gtnR-4avcA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 257
PHE A 224
TYR A 204
VAL A 266
 None
 1.22A 1ibgH-4avcA:
undetectable		 1ibgH-4avcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 166
ARG A 159
ALA A 140
TYR A 204
ALA A 325
 None
 1.37A 1mskA-4avcA:
undetectable		 1mskA-4avcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 135
LEU A 139
VAL A 328
TYR A 204
LEU A 162
 PEG  A1335 (-3.9A)
None
None
None
None
 1.10A 1s9pA-4avcA:
undetectable		 1s9pA-4avcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 135
LEU A 139
VAL A 328
TYR A 204
LEU A 162
 PEG  A1335 (-3.9A)
None
None
None
None
 1.09A 1s9pB-4avcA:
undetectable		 1s9pB-4avcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 135
LEU A 139
VAL A 328
TYR A 204
LEU A 162
 PEG  A1335 (-3.9A)
None
None
None
None
 1.11A 1s9pD-4avcA:
undetectable		 1s9pD-4avcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  57
ILE A  86
VAL A  20
PHE A  21
 None
PEG  A1335 (-4.5A)
PEG  A1335 ( 4.1A)
None
 0.91A 2cizA-4avcA:
undetectable		 2cizA-4avcA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 MET A  18
LEU A 131
ILE A 124
LEU A  32
PHE A  21
 None
PEG  A1335 (-4.3A)
None
None
None
 1.22A 3fl9A-4avcA:
undetectable		 3fl9A-4avcA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 MET A  18
LEU A 131
ILE A 124
LEU A  32
PHE A  21
 None
PEG  A1335 (-4.3A)
None
None
None
 1.24A 3fl9D-4avcA:
undetectable		 3fl9D-4avcA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 MET A  18
LEU A 131
ILE A 124
LEU A  32
PHE A  21
 None
PEG  A1335 (-4.3A)
None
None
None
 1.11A 3fl9E-4avcA:
undetectable		 3fl9E-4avcA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 242
GLU A 179
GLY A 178
 None
 0.66A 3w9tA-4avcA:
undetectable		 3w9tA-4avcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 242
GLU A 179
GLY A 178
GLN A 175
 None
 1.11A 3w9tE-4avcA:
undetectable		 3w9tE-4avcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 329
VAL A 266
VAL A 263
ARG A 326
 None
 1.11A 4m6tA-4avcA:
undetectable		 4m6tA-4avcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 313
MET A 317
VAL A 318
ASN A 322
 None
 1.26A 5b8iB-4avcA:
undetectable		 5b8iB-4avcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 182
GLY A 297
SER A 275
LEU A 274
 None
 1.26A 5bphA-4avcA:
undetectable		 5bphA-4avcA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 TYR A 182
GLY A 297
SER A 275
LEU A 274
 None
 1.25A 5bphC-4avcA:
undetectable		 5bphC-4avcA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 217
GLY A 172
HIS A 173
ASP A 214
 None
 0.83A 5nnwD-4avcA:
undetectable		 5nnwD-4avcA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 217
GLY A 172
HIS A 173
ASP A 214
 None
 0.84A 5no9D-4avcA:
undetectable		 5no9D-4avcA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  79
GLU A 106
LEU A  82
ILE A  60
VAL A 102
 CMP  A 400 (-3.5A)
None
None
None
None
 1.04A 5vlmE-4avcA:
undetectable		 5vlmE-4avcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 166
ARG A 159
ALA A 140
TYR A 204
ALA A 325
 None
 1.37A 6bm5A-4avcA:
undetectable		 6bm5A-4avcA:
21.33