SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4avx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		4 / 6 SER A  48
TYR A  44
ASP A  39
THR A  78
 None
EDO  A1234 (-4.1A)
None
None
 1.10A 3q70A-4avxA:
undetectable		 3q70A-4avxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		4 / 6 GLU A   9
TYR A  44
VAL A  79
PHE A   8
 None
EDO  A1234 (-4.1A)
None
None
 1.21A 4a97E-4avxA:
2.4		 4a97E-4avxA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		4 / 7 GLU A   9
TYR A  44
VAL A  79
PHE A   8
 None
EDO  A1234 (-4.1A)
None
None
 1.10A 4a97H-4avxA:
undetectable		 4a97H-4avxA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		3 / 3 TYR A 197
HIS A 180
ARG A 210
 None
ITP  A1227 (-3.7A)
ITP  A1227 (-4.1A)
 1.04A 4htfA-4avxA:
undetectable		 4htfA-4avxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		5 / 12 VAL A  79
ALA A  45
SER A  70
LEU A 111
VAL A  83
 None
 1.28A 4kyaB-4avxA:
undetectable		 4kyaB-4avxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		5 / 12 VAL A  79
ALA A  45
SER A  70
LEU A 111
VAL A  83
 None
 1.29A 4kyaH-4avxA:
undetectable		 4kyaH-4avxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		5 / 12 CYH A 169
ARG A 170
ALA A 163
ILE A 188
GLY A 191
 ZN  A1226 (-2.3A)
None
None
None
None
 1.11A 4r38A-4avxA:
undetectable		 4r38A-4avxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		5 / 12 CYH A 169
ARG A 170
ALA A 163
ILE A 188
GLY A 191
 ZN  A1226 (-2.3A)
None
None
None
None
 1.09A 4r38B-4avxA:
undetectable		 4r38B-4avxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		5 / 12 CYH A 169
ARG A 170
ALA A 163
ILE A 188
GLY A 191
 ZN  A1226 (-2.3A)
None
None
None
None
 1.07A 4r38C-4avxA:
undetectable		 4r38C-4avxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		5 / 12 CYH A 169
ARG A 170
ALA A 163
ILE A 188
GLY A 191
 ZN  A1226 (-2.3A)
None
None
None
None
 1.11A 4r38D-4avxA:
undetectable		 4r38D-4avxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		4 / 7 VAL A  53
LEU A  92
VAL A  83
THR A  88
 EDO  A1230 ( 4.8A)
EDO  A1230 ( 4.7A)
None
EDO  A1230 ( 4.0A)
 0.93A 5e4dA-4avxA:
undetectable
5e4dB-4avxA:
undetectable		 5e4dA-4avxA:
18.78
5e4dB-4avxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens) 		3 / 3 VAL A  67
GLN A  30
CYH A  32
 None
 0.64A 5icxC-4avxA:
undetectable
5icxF-4avxA:
undetectable		 5icxC-4avxA:
22.73
5icxF-4avxA:
5.58