SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4avy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  61
ILE A  62
THR A  63
LEU A 105
 None
 0.83A 1hmyA-4avyA:
7.8		 1hmyA-4avyA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 135
LYS A 150
VAL A  82
ILE A 153
 None
 1.37A 1opjA-4avyA:
undetectable		 1opjA-4avyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 175
GLY A 177
ILE A 131
ALA A 173
SER A 136
 None
 1.07A 1ve3B-4avyA:
6.7		 1ve3B-4avyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  41
ILE A  55
ALA A  31
VAL A  15
ILE A  26
 None
 1.14A 2nnhA-4avyA:
undetectable		 2nnhA-4avyA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  26
GLY A  23
PRO A  50
ALA A  49
ALA A  85
 None
 0.99A 3jb3A-4avyA:
4.4		 3jb3A-4avyA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 133
ILE A  22
TYR A 146
GLY A 177
 None
 0.85A 3uboB-4avyA:
6.7		 3uboB-4avyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 146
VAL A 102
SER A  88
GLY A  86
 None
 1.24A 3v4tA-4avyA:
undetectable
3v4tD-4avyA:
undetectable		 3v4tA-4avyA:
22.25
3v4tD-4avyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 121
LEU A  78
LEU A  75
VAL A  37
ARG A  56
 None
 1.40A 3zqtA-4avyA:
undetectable		 3zqtA-4avyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  26
GLY A  18
ILE A  62
ASN A 130
LEU A  14
 None
 1.08A 4a81A-4avyA:
undetectable		 4a81A-4avyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  26
ILE A  22
GLY A  21
VAL A 234
GLY A 207
 None
 0.98A 4ac9B-4avyA:
6.5
4ac9C-4avyA:
6.0		 4ac9B-4avyA:
20.26
4ac9C-4avyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 102
THR A  98
GLU A  93
GLU A  92
 None
 1.41A 4l78A-4avyA:
undetectable		 4l78A-4avyA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  21
ILE A  62
THR A  63
GLY A  86
LEU A 105
 None
 1.06A 4n48A-4avyA:
6.9		 4n48A-4avyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  21
LEU A  42
ILE A  62
THR A  63
LEU A 105
 None
 1.09A 4n48A-4avyA:
6.9		 4n48A-4avyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  26
GLY A  23
PRO A  50
ALA A  49
VAL A  15
 None
 0.98A 4rvdA-4avyA:
5.8		 4rvdA-4avyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  26
GLY A  23
PRO A  50
ALA A  49
VAL A  15
 None
 0.99A 4rvgA-4avyA:
5.8		 4rvgA-4avyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  60
LEU A  40
LEU A  68
GLU A  73
ALA A  74
 None
 1.11A 4wg0B-4avyA:
undetectable
4wg0C-4avyA:
undetectable
4wg0D-4avyA:
undetectable		 4wg0B-4avyA:
5.49
4wg0C-4avyA:
5.49
4wg0D-4avyA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  60
LEU A  40
LEU A  68
GLU A  73
ALA A  74
 None
 1.12A 4wg0D-4avyA:
undetectable
4wg0E-4avyA:
undetectable
4wg0F-4avyA:
undetectable		 4wg0D-4avyA:
5.49
4wg0E-4avyA:
5.49
4wg0F-4avyA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  60
LEU A  40
LEU A  68
GLU A  73
ALA A  74
 None
 1.11A 4wg0F-4avyA:
undetectable
4wg0G-4avyA:
undetectable
4wg0H-4avyA:
undetectable		 4wg0F-4avyA:
5.49
4wg0G-4avyA:
5.49
4wg0H-4avyA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  60
LEU A  40
LEU A  68
GLU A  73
ALA A  74
 None
 1.18A 4wg0H-4avyA:
undetectable
4wg0I-4avyA:
undetectable
4wg0J-4avyA:
undetectable		 4wg0H-4avyA:
5.49
4wg0I-4avyA:
5.49
4wg0J-4avyA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 GLU A  73
ALA A  74
LEU A  68
LEU A  60
LEU A  40
 None
 1.09A 4wg0G-4avyA:
undetectable
4wg0H-4avyA:
undetectable
4wg0I-4avyA:
undetectable		 4wg0G-4avyA:
5.49
4wg0H-4avyA:
5.49
4wg0I-4avyA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  27
GLY A  17
GLY A  23
GLY A  21
LEU A  40
 None
 1.01A 5c0oH-4avyA:
6.4		 5c0oH-4avyA:
24.03