SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.61A 1iepA-4aw2A:
19.0		 1iepA-4aw2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
LEU A 129
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
 0.54A 1t46A-4aw2A:
19.8		 1t46A-4aw2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ILE A  83
VAL A  91
LYS A 106
ASN A 206
LEU A 208
ALA A 218
ASP A 219
 None
None
EDO  A1419 (-3.3A)
None
EDO  A1420 ( 4.8A)
None
None
 0.68A 2eufB-4aw2A:
24.5		 2eufB-4aw2A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 VAL A  91
LYS A 106
ASP A 161
THR A 164
ASN A 206
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1419 (-3.3A)
None
None
None
EDO  A1420 ( 4.8A)
None
None
 0.62A 2eufB-4aw2A:
24.5		 2eufB-4aw2A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 11 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
LEU A 208
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.45A 2evaA-4aw2A:
21.2		 2evaA-4aw2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
ALA A 104
ASP A 201
LYS A 203
ASN A 206
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
None
None
None
 0.93A 2fumA-4aw2A:
21.1		 2fumA-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
ALA A 104
MET A 154
LYS A 203
ASN A 206
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
None
None
None
 0.89A 2fumB-4aw2A:
24.4		 2fumB-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
ASN A 206
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
None
None
 0.64A 2fumB-4aw2A:
24.4		 2fumB-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
ASN A 206
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
None
 0.70A 2fumC-4aw2A:
22.9		 2fumC-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 GLY A  84
VAL A  91
ALA A 104
MET A 154
LYS A 203
ASN A 206
 None
None
EDO  A1420 (-3.4A)
None
None
None
 0.55A 2fumD-4aw2A:
23.0		 2fumD-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		3 / 3 LYS A 225
GLY A  23
PRO A  18
 None
 0.89A 2hreB-4aw2A:
undetectable		 2hreB-4aw2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.62A 2hyyA-4aw2A:
19.1		 2hyyA-4aw2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.60A 2hyyB-4aw2A:
15.5		 2hyyB-4aw2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
LYS A 106
GLU A 125
LEU A 129
TYR A 156
ASP A 219
 None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
 0.75A 2ivuA-4aw2A:
23.9		 2ivuA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
LYS A 106
GLU A 125
LEU A 152
TYR A 156
ASP A 219
 None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
 0.82A 2ivuA-4aw2A:
23.9		 2ivuA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 5 ASP A 412
SER A  27
GLY A 401
ARG A  71
 None
None
None
22E  A 500 ( 4.0A)
 0.84A 2j2pA-4aw2A:
undetectable
2j2pB-4aw2A:
undetectable		 2j2pA-4aw2A:
20.28
2j2pB-4aw2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 6 ARG A  71
ASP A 412
SER A  27
GLY A 401
 22E  A 500 ( 4.0A)
None
None
None
 0.90A 2j2pA-4aw2A:
undetectable
2j2pC-4aw2A:
undetectable		 2j2pA-4aw2A:
20.28
2j2pC-4aw2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 6 ARG A  71
ASP A 412
SER A  27
GLY A 401
 22E  A 500 ( 4.0A)
None
None
None
 0.90A 2j2pD-4aw2A:
undetectable
2j2pF-4aw2A:
undetectable		 2j2pD-4aw2A:
20.28
2j2pF-4aw2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
GLU A 125
TYR A 156
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
 0.78A 2oiqA-4aw2A:
20.1		 2oiqA-4aw2A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 6 ILE A 189
TRP A 348
GLY A 333
GLY A 330
 None
 0.77A 2qx6A-4aw2A:
undetectable
2qx6B-4aw2A:
undetectable		 2qx6A-4aw2A:
19.59
2qx6B-4aw2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		3 / 3 LEU A 321
ARG A 320
ILE A 322
 None
 0.64A 2xn5B-4aw2A:
undetectable		 2xn5B-4aw2A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 LYS A  81
ILE A  83
ALA A 104
LYS A 106
GLU A 125
TYR A 156
GLY A 160
LEU A 208
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.86A 2y6oA-4aw2A:
19.7		 2y6oA-4aw2A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 8 ILE A 189
HIS A 193
ARG A 328
GLY A 330
 None
 0.89A 3b9lA-4aw2A:
undetectable		 3b9lA-4aw2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 5 ILE A 189
HIS A 193
ARG A 328
GLY A 330
 None
 1.07A 3b9mA-4aw2A:
undetectable		 3b9mA-4aw2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 GLY A  84
VAL A  91
ALA A 104
LYS A 106
MET A 154
ASN A 206
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
EDO  A1420 ( 4.8A)
None
 0.70A 3eygA-4aw2A:
22.8		 3eygA-4aw2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 GLY A  84
VAL A  91
ALA A 104
LYS A 106
MET A 154
TYR A 156
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.69A 3fupA-4aw2A:
22.7		 3fupA-4aw2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
ALA A 104
LYS A 106
MET A 154
TYR A 156
LEU A 208
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.48A 3fupB-4aw2A:
22.8		 3fupB-4aw2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 11 VAL A  91
ALA A 104
TYR A 156
GLY A 160
ASP A 161
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1420 (-4.9A)
None
None
EDO  A1420 ( 4.8A)
 0.44A 3g0fA-4aw2A:
19.9		 3g0fA-4aw2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.56A 3k5vA-4aw2A:
15.1		 3k5vA-4aw2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.55A 3k5vB-4aw2A:
18.8		 3k5vB-4aw2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 7 PHE A  88
GLY A  86
CYH A 121
PHE A 122
 EDO  A1419 ( 4.8A)
None
None
None
 0.95A 3ko0D-4aw2A:
1.3
3ko0E-4aw2A:
undetectable		 3ko0D-4aw2A:
16.27
3ko0E-4aw2A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 7 CYH A 121
PHE A 122
PHE A  88
GLY A  86
 None
None
EDO  A1419 ( 4.8A)
None
 0.91A 3ko0M-4aw2A:
1.3
3ko0P-4aw2A:
1.1		 3ko0M-4aw2A:
16.27
3ko0P-4aw2A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 7 PHE A  88
GLY A  86
CYH A 121
PHE A 122
 EDO  A1419 ( 4.8A)
None
None
None
 0.93A 3ko0M-4aw2A:
1.3
3ko0P-4aw2A:
1.1		 3ko0M-4aw2A:
16.27
3ko0P-4aw2A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 8 ALA A 104
LYS A 106
GLU A 125
LEU A 152
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
 0.36A 3lfaA-4aw2A:
21.8		 3lfaA-4aw2A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 GLY A  84
VAL A  91
ALA A 104
LYS A 106
MET A 154
TYR A 156
ALA A 218
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
EDO  A1420 (-4.9A)
None
None
 0.79A 3lxkA-4aw2A:
22.7		 3lxkA-4aw2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
LEU A 208
ALA A 218
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
None
 0.88A 3lxkA-4aw2A:
22.7		 3lxkA-4aw2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
ALA A 104
LYS A 106
TYR A 156
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.56A 3lxnA-4aw2A:
22.8		 3lxnA-4aw2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.59A 3ms9B-4aw2A:
19.1		 3ms9B-4aw2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.59A 3mssB-4aw2A:
18.9		 3mssB-4aw2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.74A 3oezB-4aw2A:
20.1		 3oezB-4aw2A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
GLU A 125
LEU A 129
TYR A 156
HIS A 199
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
None
None
 0.82A 3rgfA-4aw2A:
21.4		 3rgfA-4aw2A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 7 ILE A 187
LYS A 339
PHE A 337
GLY A 330
 None
 1.04A 3sj0X-4aw2A:
undetectable		 3sj0X-4aw2A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 9 LEU A  96
LEU A  72
ILE A 107
PHE A 103
VAL A  94
 None
 1.21A 3tmzA-4aw2A:
undetectable		 3tmzA-4aw2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
LYS A 106
LEU A 152
MET A 154
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
None
EDO  A1420 ( 4.8A)
 0.75A 3ug2A-4aw2A:
21.4		 3ug2A-4aw2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 ILE A  83
GLY A  86
GLY A  89
VAL A  91
ALA A 104
LYS A 106
LEU A 108
ASP A 219
 None
None
None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-4.2A)
None
 0.65A 3v5wA-4aw2A:
11.1		 3v5wA-4aw2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 4 LEU A 321
GLY A 269
MET A 185
PHE A 342
 None
 1.42A 3vaqB-4aw2A:
undetectable		 3vaqB-4aw2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ALA A 104
LYS A 106
GLU A 125
HIS A 199
ARG A 200
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 0.85A 3zosB-4aw2A:
20.0		 3zosB-4aw2A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
LEU A 129
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
 0.68A 4agcA-4aw2A:
19.3		 4agcA-4aw2A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 LEU A 108
LEU A 152
ASP A 201
LYS A 203
ASN A 206
GLY A 221
 EDO  A1419 (-4.2A)
None
None
None
None
EDO  A1419 (-3.7A)
 1.24A 4an2A-4aw2A:
22.3		 4an2A-4aw2A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 LEU A 152
LEU A 129
ASP A 201
LYS A 203
ASN A 206
GLY A 221
 None
None
None
None
None
EDO  A1419 (-3.7A)
 1.37A 4an2A-4aw2A:
22.3		 4an2A-4aw2A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
TYR A 156
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.76A 4bkjA-4aw2A:
20.0		 4bkjA-4aw2A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ALA A 104
LYS A 106
GLU A 125
LEU A 129
HIS A 199
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 0.56A 4c8bA-4aw2A:
21.0		 4c8bA-4aw2A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 ALA A 104
LYS A 106
GLU A 125
LEU A 129
ILE A 137
HIS A 199
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
None
EDO  A1420 ( 4.8A)
None
 0.71A 4c8bB-4aw2A:
21.1		 4c8bB-4aw2A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 10 GLY A  84
GLY A  86
VAL A  91
ALA A 104
TYR A 156
LEU A 208
 None
None
None
EDO  A1420 (-3.4A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.50A 4ckjA-4aw2A:
24.2		 4ckjA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		9 / 12 GLY A  84
VAL A  91
ALA A 104
LYS A 106
LEU A 152
MET A 154
GLY A 160
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
None
EDO  A1420 ( 4.8A)
None
 0.85A 4i22A-4aw2A:
19.1		 4i22A-4aw2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 VAL A  91
ALA A 104
ASP A 161
ASP A 201
LYS A 203
ASN A 206
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
None
None
None
None
EDO  A1420 ( 4.8A)
None
 0.69A 4i41A-4aw2A:
25.9		 4i41A-4aw2A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 11 VAL A  91
ALA A 104
LYS A 106
ASP A 161
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
EDO  A1420 ( 4.8A)
None
 0.72A 4iaaA-4aw2A:
25.7		 4iaaA-4aw2A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 GLY A  84
VAL A  91
ALA A 104
LEU A 140
LEU A 152
GLY A 160
LEU A 208
 None
None
EDO  A1420 (-3.4A)
None
None
None
EDO  A1420 ( 4.8A)
 0.55A 4ifgA-4aw2A:
23.3		 4ifgA-4aw2A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
LYS A 106
GLY A 160
ASP A 161
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
EDO  A1420 ( 4.8A)
None
 0.88A 4mkcA-4aw2A:
20.4		 4mkcA-4aw2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 VAL A  91
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
None
 1.06A 4mxyB-4aw2A:
16.5		 4mxyB-4aw2A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 VAL A  91
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
None
 1.06A 4mxzB-4aw2A:
16.5		 4mxzB-4aw2A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 8 ILE A  83
VAL A  91
ALA A 104
ASN A 206
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 ( 4.8A)
None
 0.51A 4ogrA-4aw2A:
25.2		 4ogrA-4aw2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 7 ALA A 104
ASP A 161
ASN A 206
LEU A 208
ASP A 219
 EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.61A 4ogrE-4aw2A:
25.1		 4ogrE-4aw2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 9 ILE A  83
VAL A  91
ALA A 104
ASP A 161
ASN A 206
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.77A 4ogrI-4aw2A:
25.4		 4ogrI-4aw2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
LYS A 106
TYR A 156
GLY A 160
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
None
 0.71A 4otwA-4aw2A:
19.4		 4otwA-4aw2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ALA A 104
GLU A 125
THR A 138
MET A 154
TYR A 156
ALA A 218
ASP A 219
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 (-4.9A)
None
None
 0.65A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ALA A 104
LYS A 106
GLU A 125
THR A 138
MET A 154
TYR A 156
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 (-4.9A)
None
 0.91A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 ILE A  83
ALA A 104
GLU A 125
THR A 138
TYR A 156
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
None
 0.68A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 ILE A  83
ALA A 104
LYS A 106
GLU A 125
THR A 138
TYR A 156
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.82A 4qmnA-4aw2A:
27.6		 4qmnA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 11 ILE A  83
ALA A 104
LYS A 106
GLU A 125
MET A 154
TYR A 156
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.93A 4qmsA-4aw2A:
27.5		 4qmsA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 ILE A  83
GLY A  84
VAL A  91
ALA A 104
THR A 138
MET A 154
TYR A 156
LEU A 208
 None
None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.64A 4qmzA-4aw2A:
27.5		 4qmzA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 ILE A  83
GLY A  84
VAL A  91
THR A 138
MET A 154
GLY A 160
 None
 0.69A 4qmzA-4aw2A:
27.5		 4qmzA-4aw2A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 VAL A  91
ALA A 104
LYS A 106
GLY A 160
ASN A 206
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
EDO  A1420 ( 4.8A)
None
None
 0.57A 4twpA-4aw2A:
18.2		 4twpA-4aw2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 12 ALA A 104
GLU A 125
HIS A 199
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.63A 4tyjA-4aw2A:
19.4		 4tyjA-4aw2A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 ALA A 104
LYS A 106
LEU A 129
GLY A 160
HIS A 199
LEU A 208
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
None
EDO  A1420 ( 4.8A)
 0.48A 4u0iA-4aw2A:
19.8		 4u0iA-4aw2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 11 GLY A  86
VAL A  91
ALA A 104
TYR A 156
ASN A 206
LEU A 208
ALA A 218
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
None
 0.73A 4u5jA-4aw2A:
22.6		 4u5jA-4aw2A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ALA A 104
LYS A 106
GLU A 125
LEU A 152
GLY A 160
LEU A 208
THR A 138
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 1.43A 4wkqA-4aw2A:
22.5		 4wkqA-4aw2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		3 / 3 VAL A 130
PHE A 402
ARG A 123
 None
 0.97A 4xr4B-4aw2A:
undetectable		 4xr4B-4aw2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 12 ALA A 104
LYS A 106
LEU A 129
ASP A 219
PHE A 220
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
None
 0.87A 4xv2B-4aw2A:
20.2		 4xv2B-4aw2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 7 ALA A 188
ASP A 205
THR A 280
GLU A 274
 None
 1.00A 5bs8A-4aw2A:
2.9
5bs8B-4aw2A:
undetectable
5bs8C-4aw2A:
3.5		 5bs8A-4aw2A:
18.77
5bs8B-4aw2A:
22.01
5bs8C-4aw2A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
 0.58A 5bvwA-4aw2A:
19.5		 5bvwA-4aw2A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 12 VAL A  91
ALA A 104
LYS A 106
LEU A 129
PHE A 220
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
 0.79A 5cswA-4aw2A:
20.3		 5cswA-4aw2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 12 GLY A  84
VAL A  91
ALA A 104
LYS A 106
ASP A 219
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
 0.61A 5hieC-4aw2A:
20.4		 5hieC-4aw2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 8 ILE A  83
GLY A  84
ASP A 219
PHE A 220
 None
 0.93A 5hieD-4aw2A:
20.4		 5hieD-4aw2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 6 ARG A  71
ASP A 412
GLY A 401
ASP A  33
 22E  A 500 ( 4.0A)
None
None
22E  A 500 (-3.6A)
 1.31A 5hp1A-4aw2A:
undetectable		 5hp1A-4aw2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 ILE A  83
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.68A 5i9xA-4aw2A:
15.4		 5i9xA-4aw2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 ILE A  83
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.69A 5i9yA-4aw2A:
20.0		 5i9yA-4aw2A:
24.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 7 GLY A  84
GLY A  86
GLY A  89
VAL A  91
LEU A 108
 None
None
None
None
EDO  A1419 (-4.2A)
 0.30A 5izjB-4aw2A:
31.7		 5izjB-4aw2A:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 7 GLY A  84
GLY A  86
VAL A  91
LYS A 106
LEU A 108
 None
None
None
EDO  A1419 (-3.3A)
EDO  A1419 (-4.2A)
 0.32A 5izjA-4aw2A:
32.9		 5izjA-4aw2A:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 7 GLY A  84
GLY A  86
VAL A  91
LYS A 106
ASP A 219
 None
None
None
EDO  A1419 (-3.3A)
None
 0.54A 5j5xA-4aw2A:
36.0		 5j5xA-4aw2A:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 12 GLY A 269
MET A 272
LEU A 276
ALA A 314
PHE A 303
 None
 1.40A 5kc4E-4aw2A:
undetectable		 5kc4E-4aw2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		8 / 12 GLY A  84
VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
ALA A 218
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
None
 0.74A 5l2iA-4aw2A:
7.1		 5l2iA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ILE A  83
GLY A  84
VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
 None
None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
 0.90A 5l2iA-4aw2A:
7.1		 5l2iA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 GLY A  84
ALA A 104
ASP A 161
THR A 164
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.95A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 GLY A  84
ASP A 161
THR A 164
LEU A 208
ALA A 218
ASP A 219
 None
None
None
EDO  A1420 ( 4.8A)
None
None
 0.94A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 ILE A  83
VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
 None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
 0.98A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
ASP A 161
THR A 164
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.73A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ASP A 161
THR A 164
LEU A 208
ALA A 218
ASP A 219
 None
None
None
EDO  A1420 ( 4.8A)
None
None
 0.78A 5l2tA-4aw2A:
7.0		 5l2tA-4aw2A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		5 / 9 ILE A  83
GLY A  84
VAL A  91
ALA A 104
MET A 154
 None
None
None
EDO  A1420 (-3.4A)
None
 0.63A 5lw1B-4aw2A:
22.8		 5lw1B-4aw2A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ILE A  83
GLY A  84
VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
 None
None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
 0.69A 5mafA-4aw2A:
27.1		 5mafA-4aw2A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ILE A  83
VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
GLY A 160
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
 0.81A 5mafA-4aw2A:
27.1		 5mafA-4aw2A:
14.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 10 VAL A  91
ALA A 104
MET A 154
TYR A 156
LEU A 208
PHE A 371
 None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
EDO  A1420 ( 4.6A)
 0.39A 5n3hA-4aw2A:
36.5		 5n3hA-4aw2A:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		4 / 8 ALA A 104
GLU A 125
LEU A 208
ASP A 219
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 ( 4.8A)
None
 0.33A 5owrA-4aw2A:
21.2		 5owrA-4aw2A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
LEU A 152
GLY A 160
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
 0.96A 5vcyA-4aw2A:
23.3		 5vcyA-4aw2A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 ALA A 104
LYS A 106
GLU A 125
LEU A 152
GLY A 160
LEU A 208
ASP A 219
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 0.77A 5y7zB-4aw2A:
24.8		 5y7zB-4aw2A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
GLY A 160
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.58A 5y80A-4aw2A:
23.8		 5y80A-4aw2A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
GLU A 125
TYR A 156
GLY A 160
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
None
 0.63A 5zv2A-4aw2A:
19.1		 5zv2A-4aw2A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		6 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
GLY A 160
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
 0.42A 5zv2B-4aw2A:
19.0		 5zv2B-4aw2A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA
(Rattus
norvegicus) 		7 / 12 VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.50A 6bsdA-4aw2A:
19.3		 6bsdA-4aw2A:
10.49