SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4awd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		3 / 3 ALA A 313
VAL A  46
TRP A  45
 None
 0.90A 1grmA-4awdA:
undetectable		 1grmA-4awdA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		3 / 3 ALA A 313
VAL A  46
TRP A  45
 None
 0.91A 1grmB-4awdA:
undetectable		 1grmB-4awdA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 12 ARG A  76
GLU A 284
GLU A 178
ASN A 203
TYR A 286
 GOL  A1322 (-3.9A)
GOL  A1322 (-2.6A)
GOL  A1322 ( 3.7A)
None
None
 1.43A 1nncA-4awdA:
undetectable		 1nncA-4awdA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		4 / 7 ALA A 128
PHE A 148
ARG A 312
ASN A  48
 None
 1.20A 1t9wA-4awdA:
undetectable		 1t9wA-4awdA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 9 LEU A 116
ASN A  97
GLY A 181
ILE A 182
THR A 285
 None
 1.33A 3spkA-4awdA:
undetectable		 3spkA-4awdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 12 ARG A  76
GLU A 284
GLU A 178
ASN A 203
TYR A 286
 GOL  A1322 (-3.9A)
GOL  A1322 (-2.6A)
GOL  A1322 ( 3.7A)
None
None
 1.40A 4b7nA-4awdA:
undetectable		 4b7nA-4awdA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 12 ARG A  76
GLU A 284
GLU A 178
ASN A 203
TYR A 286
 GOL  A1322 (-3.9A)
GOL  A1322 (-2.6A)
GOL  A1322 ( 3.7A)
None
None
 1.39A 4b7qC-4awdA:
undetectable		 4b7qC-4awdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 12 ARG A  76
GLU A 284
GLU A 178
ASN A 203
TYR A 286
 GOL  A1322 (-3.9A)
GOL  A1322 (-2.6A)
GOL  A1322 ( 3.7A)
None
None
 1.40A 4b7qD-4awdA:
undetectable		 4b7qD-4awdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 12 ARG A  76
GLU A 284
GLU A 178
ASN A 203
TYR A 286
 GOL  A1322 (-3.9A)
GOL  A1322 (-2.6A)
GOL  A1322 ( 3.7A)
None
None
 1.39A 4cpzD-4awdA:
undetectable		 4cpzD-4awdA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 11 ALA A 139
THR A 230
MET A 200
PHE A 252
THR A 306
 None
 1.43A 4kyaE-4awdA:
undetectable		 4kyaE-4awdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		3 / 3 ARG A 136
ASP A 309
TRP A 310
 None
CA  A1321 (-3.4A)
None
 0.22A 4xdqA-4awdA:
18.3		 4xdqA-4awdA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		3 / 3 VAL A  47
TYR A  26
ALA A  29
 None
 0.52A 4ybnA-4awdA:
undetectable		 4ybnA-4awdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 11 THR A 179
THR A 306
THR A 305
GLY A 181
ALA A 234
 None
 1.40A 5bxnV-4awdA:
undetectable
5bxnb-4awdA:
undetectable		 5bxnV-4awdA:
20.34
5bxnb-4awdA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 11 THR A 179
THR A 306
THR A 305
GLY A 181
ALA A 234
 None
 1.41A 5bxnH-4awdA:
undetectable
5bxnN-4awdA:
undetectable		 5bxnH-4awdA:
20.34
5bxnN-4awdA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		5 / 11 ILE A 279
TRP A  65
THR A 135
VAL A 282
LEU A  93
 None
None
None
GOL  A1322 ( 4.8A)
None
 1.36A 5jkwA-4awdA:
undetectable		 5jkwA-4awdA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		4 / 6 PHE A 252
ILE A 177
MET A 200
ASN A 201
 None
 1.47A 6dhbA-4awdA:
undetectable		 6dhbA-4awdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4awd BETA-PORPHYRANASE
(Bacteroides
plebeius) 		4 / 8 ASP A 236
ARG A 136
HIS A 238
ASP A 309
 None
None
None
CA  A1321 (-3.4A)
 1.12A 6mn4D-4awdA:
undetectable		 6mn4D-4awdA:
17.11