SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4awe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 6 GLN A 345
TYR A  29
ASP A 359
GLY A  78
 CL  A1394 (-3.7A)
CL  A1394 (-4.7A)
CL  A1394 ( 4.5A)
CL  A1394 ( 3.9A)
 1.26A 1ekjC-4aweA:
undetectable
1ekjD-4aweA:
undetectable		 1ekjC-4aweA:
22.16
1ekjD-4aweA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 1.00A 1fohA-4aweA:
undetectable		 1fohA-4aweA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.99A 1fohB-4aweA:
undetectable		 1fohB-4aweA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.96A 1fohC-4aweA:
undetectable		 1fohC-4aweA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.97A 1fohD-4aweA:
undetectable		 1fohD-4aweA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 GLU A 300
ILE A 118
LEU A 178
ASP A 261
LEU A 223
 None
 1.09A 1hvyD-4aweA:
undetectable		 1hvyD-4aweA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 ARG A 310
ASP A 359
ASN A 356
 None
CL  A1394 ( 4.5A)
None
 0.84A 1nbhA-4aweA:
undetectable		 1nbhA-4aweA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 ARG A 310
ASP A 359
ASN A 356
 None
CL  A1394 ( 4.5A)
None
 0.86A 1nbhD-4aweA:
undetectable		 1nbhD-4aweA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 1.02A 1pn0A-4aweA:
undetectable		 1pn0A-4aweA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 1.00A 1pn0B-4aweA:
undetectable		 1pn0B-4aweA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.98A 1pn0C-4aweA:
undetectable		 1pn0C-4aweA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.97A 1pn0D-4aweA:
undetectable		 1pn0D-4aweA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 GLU A 301
ASN A  27
TRP A  57
 TRS  A1391 (-2.8A)
None
None
 1.21A 1r15C-4aweA:
undetectable		 1r15C-4aweA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 GLU A 301
ASN A  27
TRP A  57
 TRS  A1391 (-2.8A)
None
None
 1.26A 1r15D-4aweA:
undetectable		 1r15D-4aweA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 GLU A 301
ASN A  27
TRP A  57
 TRS  A1391 (-2.8A)
None
None
 1.22A 1r15E-4aweA:
undetectable		 1r15E-4aweA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 GLU A 301
ASN A  27
TRP A  57
 TRS  A1391 (-2.8A)
None
None
 1.21A 1r15F-4aweA:
undetectable		 1r15F-4aweA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 7 GLN A 345
TYR A 268
TRP A  57
GLU A 181
 CL  A1394 (-3.7A)
TRS  A1391 (-4.4A)
None
TRS  A1391 ( 2.7A)
 1.28A 2aowA-4aweA:
1.4		 2aowA-4aweA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 7 SER A 289
ASP A 252
GLN A 281
TRP A 282
 None
 1.13A 2cmlA-4aweA:
undetectable		 2cmlA-4aweA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 4 PRO A 193
ASP A 132
ASP A  61
ASP A 145
 None
 1.29A 2nyuA-4aweA:
undetectable		 2nyuA-4aweA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 GLN A  96
THR A 122
TRP A 207
 None
 1.18A 2rctA-4aweA:
undetectable		 2rctA-4aweA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		6 / 12 ASN A 180
GLU A 181
HIS A 266
TYR A 268
GLU A 301
TRP A 344
 TRS  A1391 (-2.7A)
TRS  A1391 ( 2.7A)
None
TRS  A1391 (-4.4A)
TRS  A1391 (-2.8A)
TRS  A1391 (-3.8A)
 0.84A 2v3dA-4aweA:
7.5		 2v3dA-4aweA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 11 ASN A 180
GLU A 181
TYR A 268
GLU A 301
TRP A 344
 TRS  A1391 (-2.7A)
TRS  A1391 ( 2.7A)
TRS  A1391 (-4.4A)
TRS  A1391 (-2.8A)
TRS  A1391 (-3.8A)
 0.89A 2v3dB-4aweA:
6.3		 2v3dB-4aweA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 8 ALA A 110
LEU A 117
ILE A  39
THR A 113
 None
 0.78A 2w9sE-4aweA:
undetectable		 2w9sE-4aweA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 8 LEU A 338
ILE A 283
TYR A 302
GLY A 328
 None
 0.96A 3b9lA-4aweA:
undetectable		 3b9lA-4aweA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 PHE A 103
MET A 163
THR A 165
VAL A 119
LEU A 117
 None
 1.34A 3elzA-4aweA:
undetectable		 3elzA-4aweA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 GLU A 300
ILE A 118
LEU A 178
ASP A 261
LEU A 223
 None
 1.13A 3k2hA-4aweA:
undetectable		 3k2hA-4aweA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 GLU A 300
ILE A 118
LEU A 178
ASP A 261
LEU A 223
 None
 1.14A 3k2hB-4aweA:
undetectable		 3k2hB-4aweA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 8 ASP A 145
ASP A 144
GLY A 198
PRO A 193
 None
 0.92A 3s3mA-4aweA:
undetectable		 3s3mA-4aweA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 PHE A  14
PHE A  21
VAL A  53
PHE A  23
PHE A 262
 None
 1.33A 3t3qA-4aweA:
undetectable		 3t3qA-4aweA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 PHE A  14
PHE A  21
VAL A  53
PHE A  23
PHE A 262
 None
 1.38A 3t3qB-4aweA:
undetectable		 3t3qB-4aweA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 PHE A  14
PHE A  21
VAL A  53
PHE A  23
PHE A 262
 None
 1.33A 3t3qC-4aweA:
undetectable		 3t3qC-4aweA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 10 PHE A  14
PHE A  21
VAL A  53
PHE A  23
PHE A 262
 None
 1.38A 3t3qD-4aweA:
undetectable		 3t3qD-4aweA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 TYR A 302
GLY A  25
LEU A 299
GLY A 340
ALA A  46
 None
None
None
ACT  A1392 (-3.4A)
None
 1.16A 3vywC-4aweA:
undetectable		 3vywC-4aweA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 ASP A 104
LYS A 105
ASP A 108
 None
 0.76A 4a7tA-4aweA:
undetectable		 4a7tA-4aweA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 GLU A 300
ILE A 118
LEU A 178
ASP A 261
LEU A 223
 None
 1.14A 4foxA-4aweA:
undetectable		 4foxA-4aweA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 GLU A 300
ILE A 118
LEU A 178
ASP A 261
LEU A 223
 None
 1.15A 4foxB-4aweA:
undetectable		 4foxB-4aweA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 12 GLU A 300
ILE A 118
LEU A 178
ASP A 261
LEU A 223
 None
 1.08A 4foxG-4aweA:
undetectable		 4foxG-4aweA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		3 / 3 TYR A 128
GLN A 345
TRP A 125
 None
CL  A1394 (-3.7A)
TRS  A1391 ( 4.8A)
 0.98A 4kn2C-4aweA:
undetectable		 4kn2C-4aweA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		5 / 11 ARG A  55
ALA A 339
ASP A  12
ILE A 332
THR A 264
 TRS  A1391 ( 4.9A)
None
None
None
None
 0.94A 4l1aA-4aweA:
undetectable		 4l1aA-4aweA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 7 PHE A  54
ILE A 115
PHE A 346
GLY A  42
 None
 0.89A 4ze3A-4aweA:
undetectable		 4ze3A-4aweA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 7 ALA A 288
ASP A 250
ARG A 253
GLY A 256
 None
 0.96A 5bs8A-4aweA:
undetectable
5bs8B-4aweA:
undetectable
5bs8C-4aweA:
undetectable		 5bs8A-4aweA:
21.04
5bs8B-4aweA:
22.25
5bs8C-4aweA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 7 ALA A 288
ASP A 250
ARG A 253
GLY A 256
 None
 0.96A 5btdA-4aweA:
undetectable
5btdB-4aweA:
undetectable
5btdC-4aweA:
undetectable		 5btdA-4aweA:
21.04
5btdB-4aweA:
22.25
5btdC-4aweA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 7 ALA A 288
ASP A 250
ARG A 253
GLY A 256
 None
 0.93A 5btdA-4aweA:
undetectable
5btdC-4aweA:
undetectable
5btdD-4aweA:
1.3		 5btdA-4aweA:
21.04
5btdC-4aweA:
21.04
5btdD-4aweA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 8 PHE A  54
ILE A 115
PHE A 346
GLY A  42
 None
 0.89A 5esjA-4aweA:
undetectable		 5esjA-4aweA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 6 TYR A 159
PHE A 156
PHE A 103
THR A  56
 None
 1.21A 5g08A-4aweA:
undetectable		 5g08A-4aweA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 6 GLY A  78
ILE A 363
TYR A 364
TYR A 353
 CL  A1394 ( 3.9A)
None
None
None
 1.03A 5iwuA-4aweA:
undetectable		 5iwuA-4aweA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4awe ENDO-BETA-D-1,4-MANN
ANASE
(Neurospora
sitophila) 		4 / 6 GLY A 347
TYR A 364
GLY A 350
ASN A 356
 None
 0.65A 5k4pA-4aweA:
1.7		 5k4pA-4aweA:
21.43