SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4awl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT GAMMA
(Homo
sapiens) 		3 / 3 ARG C  93
ILE C  86
TRP C  85
 None
 1.22A 1m8eB-4awlC:
undetectable		 1m8eB-4awlC:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 ARG A 267
ARG A 266
PRO A 263
 None
 0.75A 2wljA-4awlA:
undetectable		 2wljA-4awlA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT GAMMA
(Homo
sapiens) 		3 / 3 ARG C  93
ILE C  86
TRP C  85
 None
 1.15A 3e68A-4awlC:
undetectable		 3e68A-4awlC:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT GAMMA
(Homo
sapiens) 		3 / 3 ARG C  93
ILE C  86
TRP C  85
 None
 1.18A 3e6tB-4awlC:
undetectable		 3e6tB-4awlC:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4awl NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 LYS A 282
ARG A 281
HIS A 277
 None
 1.08A 4zbrA-4awlA:
undetectable		 4zbrA-4awlA:
8.23