SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4awn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		5 / 12 TYR A 151
ALA A 230
ILE A 214
VAL A 225
ALA A 224
 None
 1.17A 1udtA-4awnA:
undetectable		 1udtA-4awnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		3 / 3 ARG A 117
ASP A 153
ASP A  99
 None
None
CA  A 300 (-2.5A)
 0.55A 2ejtA-4awnA:
undetectable		 2ejtA-4awnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		4 / 6 ALA A 142
ASP A 145
GLU A 143
ARG A  73
 None
 1.40A 2ouzA-4awnA:
undetectable		 2ouzA-4awnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		5 / 12 ASP A  58
LEU A  29
SER A  30
ILE A  25
LEU A  51
 None
 1.27A 3ko0G-4awnA:
undetectable
3ko0H-4awnA:
undetectable
3ko0I-4awnA:
undetectable
3ko0J-4awnA:
undetectable		 3ko0G-4awnA:
16.33
3ko0H-4awnA:
16.33
3ko0I-4awnA:
16.33
3ko0J-4awnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		5 / 12 ASP A  58
LEU A  51
LEU A  29
SER A  30
ILE A  25
 None
 1.24A 3ko0M-4awnA:
undetectable
3ko0N-4awnA:
undetectable
3ko0O-4awnA:
undetectable
3ko0P-4awnA:
undetectable		 3ko0M-4awnA:
16.33
3ko0N-4awnA:
16.33
3ko0O-4awnA:
16.33
3ko0P-4awnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		5 / 11 LEU A 195
VAL A 225
ALA A 224
PHE A 128
PHE A 118
 None
 1.34A 3n23C-4awnA:
undetectable		 3n23C-4awnA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		5 / 12 LEU A  81
ILE A  25
GLY A  12
ILE A   8
ALA A  47
 None
 0.81A 3uj7A-4awnA:
undetectable		 3uj7A-4awnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		5 / 12 ALA A  47
LYS A  50
LEU A  51
ASN A  54
ILE A   8
 None
 1.14A 3ut5B-4awnA:
undetectable		 3ut5B-4awnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		4 / 8 MET A 166
ILE A   3
PRO A 113
VAL A 116
 None
 1.34A 4f4dB-4awnA:
undetectable		 4f4dB-4awnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		3 / 3 SER A 250
GLU A  78
GLU A 143
 None
 0.77A 4ymgB-4awnA:
2.5		 4ymgB-4awnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		4 / 5 THR A 203
ALA A 204
THR A 205
HIS A 252
 CA  A 301 (-3.7A)
None
None
PO4  A 310 (-4.1A)
 0.93A 5ecmA-4awnA:
undetectable		 5ecmA-4awnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		4 / 6 THR A 203
ALA A 204
THR A 205
HIS A 252
 CA  A 301 (-3.7A)
None
None
PO4  A 310 (-4.1A)
 0.90A 5ecoA-4awnA:
undetectable		 5ecoA-4awnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		5 / 12 ALA A 204
ARG A  31
GLN A  27
GLY A 240
LEU A 241
 None
 1.07A 5m54E-4awnA:
undetectable		 5m54E-4awnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		4 / 7 GLN A 155
LEU A 152
ASP A 149
ALA A 146
 None
 1.05A 5nwvA-4awnA:
undetectable		 5nwvA-4awnA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		3 / 3 HIS A 134
ASP A 168
HIS A 252
 PO4  A 310 (-3.9A)
PO4  A 310 (-2.7A)
PO4  A 310 (-4.1A)
 0.77A 5oexB-4awnA:
undetectable		 5oexB-4awnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		3 / 3 HIS A 134
ASP A 168
HIS A 252
 PO4  A 310 (-3.9A)
PO4  A 310 (-2.7A)
PO4  A 310 (-4.1A)
 0.77A 5oexD-4awnA:
undetectable		 5oexD-4awnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens) 		4 / 8 ALA A 210
THR A 202
TRP A 194
ALA A   4
 None
None
BTB  A 315 ( 4.9A)
None
 1.04A 5x2tI-4awnA:
undetectable
5x2tJ-4awnA:
undetectable
5x2tK-4awnA:
undetectable
5x2tL-4awnA:
undetectable		 5x2tI-4awnA:
20.50
5x2tJ-4awnA:
21.58
5x2tK-4awnA:
20.50
5x2tL-4awnA:
21.58