SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4axg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 5 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 1.17A 1mz9D-4axgA:
undetectable		 1mz9D-4axgA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 0.99A 1mz9E-4axgA:
undetectable		 1mz9E-4axgA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 6 PRO A 114
HIS A 111
ASP A 104
TYR A 109
 None
 1.31A 2lh8A-4axgA:
undetectable		 2lh8A-4axgA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 8 ILE A 148
ILE A 194
ALA A 183
TRP A 146
 None
 0.96A 4ou1A-4axgA:
undetectable		 4ou1A-4axgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 4 ASN A 192
ILE A 112
TYR A  80
PHE A 127
 None
 1.27A 5igvA-4axgA:
undetectable		 5igvA-4axgA:
20.71