SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4axj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OC8_A_HU5A999_1 (HEPATITIS C VIRUS)	4axj	ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN (Clostridioides difficile)	5 / 12	ILE A 10 LEU A 72 GLY A 70 ALA A 64 ALA A 63	None	0.99A	2oc8A-4axjA: undetectable	2oc8A-4axjA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_NCAA493_0 (CHORISMATE SYNTHASE)	4axj	ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN (Clostridioides difficile)	5 / 11	ARG A 68 ALA A 24 ALA A 63 ALA A 66 VAL A 69	None	1.07A	2qhfA-4axjA: undetectable	2qhfA-4axjA: 16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XH9_A_J01A1437_1 (ORF12)	4axj	ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN (Clostridioides difficile)	5 / 11	THR A 12 ALA A 63 GLY A 62 ALA A 21 MET A 25	None	1.29A	2xh9A-4axjA: undetectable	2xh9A-4axjA: 12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXX_C_DR7C100_2 (HIV-1 PROTEASE)	4axj	ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN (Clostridioides difficile)	5 / 11	ALA A 63 GLY A 70 VAL A 69 VAL A 46 ILE A 10	None	1.01A	3oxxD-4axjA: undetectable	3oxxD-4axjA: 24.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OC8_A_HU5A999_1","HEPATITIS C VIRUS","4axj","ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN","Clostridioides difficile",5,"ILE A  10;LEU A  72;GLY A  70;ALA A  64;ALA A  63","None","0.99A","2oc8A-4axjA:undetectable","2oc8A-4axjA:24.14"],["2QHF_A_NCAA493_0","CHORISMATE SYNTHASE","4axj","ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN","Clostridioides difficile",5,"ARG A  68;ALA A  24;ALA A  63;ALA A  66;VAL A  69","None","1.07A","2qhfA-4axjA:undetectable","2qhfA-4axjA:16.10"],["2XH9_A_J01A1437_1","ORF12","4axj","ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN","Clostridioides difficile",5,"THR A  12;ALA A  63;GLY A  62;ALA A  21;MET A  25","None","1.29A","2xh9A-4axjA:undetectable","2xh9A-4axjA:12.88"],["3OXX_C_DR7C100_2","HIV-1 PROTEASE;HIV-1 PROTEASE","4axj","ETHANOLAMINE CARBOXYSOME STRUCTURAL PROTEIN","Clostridioides difficile",5,"ALA A  63;GLY A  70;VAL A  69;VAL A  46;ILE A  10","None","1.01A","3oxxD-4axjA:undetectable","3oxxD-4axjA:24.56"]]