SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4axk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE
(Corynebacterium
efficiens) 		6 / 12 LEU A 158
LEU A 155
LEU A 107
ALA A 106
ILE A 102
ILE A 196
 None
 1.29A 1tw4A-4axkA:
undetectable		 1tw4A-4axkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE
(Corynebacterium
efficiens) 		4 / 5 TRP A 112
ALA A 106
LEU A  89
ALA A 105
 None
 1.26A 2jstA-4axkA:
undetectable
2jstB-4axkA:
undetectable		 2jstA-4axkA:
14.92
2jstB-4axkA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE
(Corynebacterium
efficiens) 		4 / 7 ARG A 232
GLY A 200
VAL A 222
ASP A 170
 None
 0.95A 2y05A-4axkA:
undetectable
2y05B-4axkA:
undetectable		 2y05A-4axkA:
23.95
2y05B-4axkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE
(Corynebacterium
efficiens) 		5 / 12 PHE A  50
GLY A  82
ILE A  69
LEU A  48
ASN A 101
 None
GOL  A1249 ( 4.3A)
None
None
None
 1.24A 3eeoA-4axkA:
2.1		 3eeoA-4axkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE
(Corynebacterium
efficiens) 		4 / 7 GLY A 200
THR A 169
VAL A 222
HIS A  49
 None
 1.01A 4qwpB-4axkA:
undetectable		 4qwpB-4axkA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE
(Corynebacterium
efficiens) 		4 / 6 GLY A 148
THR A 139
ILE A 128
PHE A 166
 None
 0.75A 6f8cA-4axkA:
undetectable		 6f8cA-4axkA:
14.62