SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4axn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4axn CHITINASE C1
(Serratia
marcescens) 		3 / 3 ASN A  93
PHE A  85
VAL A  99
 CA  A1329 (-3.1A)
None
None
 0.78A 1kijA-4axnA:
undetectable		 1kijA-4axnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 10 PHE A  66
GLY A 105
ASP A 139
TYR A 208
TRP A 300
 None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-4.6A)
ACT  A1330 ( 4.1A)
 0.98A 2a3bB-4axnA:
20.3		 2a3bB-4axnA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		6 / 12 TRP A  34
PHE A  66
GLY A 105
ASP A 139
TYR A 208
TRP A 300
 None
None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-4.6A)
ACT  A1330 ( 4.1A)
 1.07A 2a3cB-4axnA:
20.3		 2a3cB-4axnA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 5 LEU A 100
ASP A 137
GLY A 261
VAL A  61
 None
 0.89A 2aojA-4axnA:
undetectable		 2aojA-4axnA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 5 LEU A 243
ALA A 251
LEU A 190
MET A 176
 None
 1.25A 2oaxA-4axnA:
undetectable		 2oaxA-4axnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 12 LEU A 154
ILE A 110
LEU A 112
ALA A 157
VAL A 161
 None
 1.20A 2qo6A-4axnA:
undetectable		 2qo6A-4axnA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 7 GLY A 211
THR A 271
GLN A 210
PHE A 180
 None
 1.15A 2qx4A-4axnA:
undetectable
2qx4B-4axnA:
undetectable		 2qx4A-4axnA:
20.65
2qx4B-4axnA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		6 / 9 PHE A  66
GLY A 105
ASP A 139
GLN A 206
TYR A 208
TRP A 300
 None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-3.7A)
ACT  A1331 (-4.6A)
ACT  A1330 ( 4.1A)
 0.35A 2uy4A-4axnA:
23.6		 2uy4A-4axnA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4axn CHITINASE C1
(Serratia
marcescens) 		8 / 11 PHE A  66
GLY A 105
ALA A 106
ASP A 139
GLN A 206
TYR A 208
ASN A 209
TRP A 300
 None
None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-3.7A)
ACT  A1331 (-4.6A)
None
ACT  A1330 ( 4.1A)
 0.73A 2xtkA-4axnA:
23.3		 2xtkA-4axnA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4axn CHITINASE C1
(Serratia
marcescens) 		8 / 11 PHE A  66
GLY A 105
ASP A 139
GLN A 206
TYR A 208
ASN A 209
ALA A 269
TRP A 300
 None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-3.7A)
ACT  A1331 (-4.6A)
None
None
ACT  A1330 ( 4.1A)
 0.52A 2xtkA-4axnA:
23.3		 2xtkA-4axnA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4axn CHITINASE C1
(Serratia
marcescens) 		6 / 10 PHE A  66
GLY A 105
ASP A 139
GLN A 206
TYR A 208
TRP A 300
 None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-3.7A)
ACT  A1331 (-4.6A)
ACT  A1330 ( 4.1A)
 0.46A 2xtkB-4axnA:
23.2		 2xtkB-4axnA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 12 TYR A 207
PHE A 180
GLY A 211
PHE A 235
PRO A 263
 None
 1.31A 2y7kC-4axnA:
undetectable		 2y7kC-4axnA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 12 ILE A 101
MET A  18
ALA A  98
LEU A 100
ILE A  21
 None
 1.08A 3gwsX-4axnA:
undetectable		 3gwsX-4axnA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 9 LEU A 262
TYR A 323
GLY A 296
LEU A 236
TYR A 207
 None
 1.26A 3hvtA-4axnA:
0.8		 3hvtA-4axnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 9 LEU A 262
TYR A 323
GLY A 296
LEU A 236
TYR A 207
 None
 1.36A 3lp0A-4axnA:
1.0		 3lp0A-4axnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 10 LEU A 262
TYR A 323
GLY A 296
LEU A 236
TYR A 207
 None
 1.34A 3lp1A-4axnA:
undetectable		 3lp1A-4axnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 12 PHE A  30
SER A 102
LEU A 136
ALA A 204
PHE A 202
 ACT  A1331 (-3.8A)
None
None
None
None
 1.48A 3nuvA-4axnA:
undetectable		 3nuvA-4axnA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 7 ASP A  82
PHE A  85
GLY A 132
PHE A  75
 None
None
CA  A1329 (-3.9A)
None
 1.06A 3vnsA-4axnA:
undetectable		 3vnsA-4axnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 11 PHE A  66
GLY A 105
ASP A 139
TYR A 208
TRP A 300
 None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-4.6A)
ACT  A1330 ( 4.1A)
 0.60A 3wqvA-4axnA:
20.6		 3wqvA-4axnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 11 PHE A  66
GLY A 105
ASP A 139
TYR A 208
TRP A 300
 None
None
ACT  A1331 (-2.7A)
ACT  A1331 (-4.6A)
ACT  A1330 ( 4.1A)
 0.60A 3wqwA-4axnA:
20.6		 3wqwA-4axnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 5 TYR A 207
LEU A 239
TYR A 250
LEU A 183
 None
 1.38A 4em2A-4axnA:
undetectable		 4em2A-4axnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 7 GLY A 104
ILE A 110
ASN A 150
MET A  28
 None
 1.12A 4g0vA-4axnA:
undetectable		 4g0vA-4axnA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 11 LEU A 196
LYS A 159
LEU A 158
GLU A 117
LEU A 154
 None
 0.98A 4wg0J-4axnA:
undetectable
4wg0K-4axnA:
undetectable
4wg0L-4axnA:
undetectable		 4wg0J-4axnA:
3.92
4wg0K-4axnA:
3.92
4wg0L-4axnA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 11 GLU A 117
LEU A 154
LYS A 159
LEU A 158
LEU A 196
 None
 0.90A 4wg0I-4axnA:
undetectable
4wg0J-4axnA:
undetectable
4wg0K-4axnA:
undetectable		 4wg0I-4axnA:
3.92
4wg0J-4axnA:
3.92
4wg0K-4axnA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 5 VAL A  99
ASP A 134
PHE A  85
GLY A 132
 None
CA  A1329 (-2.9A)
None
CA  A1329 (-3.9A)
 1.12A 4xp6A-4axnA:
undetectable		 4xp6A-4axnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 5 GLN A 206
PRO A 178
ILE A 138
ASP A 137
 ACT  A1331 (-3.7A)
None
None
None
 1.41A 4z4hA-4axnA:
undetectable		 4z4hA-4axnA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 8 PHE A  66
GLY A 105
TYR A 208
TRP A 300
 None
None
ACT  A1331 (-4.6A)
ACT  A1330 ( 4.1A)
 0.50A 5gqbA-4axnA:
19.7		 5gqbA-4axnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 11 LEU A 262
TYR A 323
GLY A 296
LEU A 236
TYR A 207
 None
 1.32A 5hbmA-4axnA:
undetectable		 5hbmA-4axnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 12 ILE A 124
LEU A 158
ILE A 110
LEU A 140
PRO A 178
 None
 1.08A 5ienA-4axnA:
undetectable		 5ienA-4axnA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 10 ILE A 124
LEU A 158
ILE A 110
LEU A 140
PRO A 178
 None
 1.13A 5ienB-4axnA:
undetectable		 5ienB-4axnA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4axn CHITINASE C1
(Serratia
marcescens) 		3 / 3 TYR A  59
SER A 301
TRP A 317
 None
 1.04A 5n8jB-4axnA:
undetectable		 5n8jB-4axnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4axn CHITINASE C1
(Serratia
marcescens) 		3 / 3 TYR A  59
SER A 301
TRP A 317
 None
 1.07A 5n8jA-4axnA:
undetectable		 5n8jA-4axnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4axn CHITINASE C1
(Serratia
marcescens) 		3 / 3 TYR A  59
SER A 301
TRP A 317
 None
 1.06A 5n8jD-4axnA:
undetectable		 5n8jD-4axnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4axn CHITINASE C1
(Serratia
marcescens) 		4 / 8 ALA A 177
ASP A 137
LEU A 100
TYR A 208
 ACT  A1331 ( 3.9A)
None
None
ACT  A1331 (-4.6A)
 0.81A 5uihA-4axnA:
undetectable		 5uihA-4axnA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 12 PHE A  30
GLY A 104
ALA A 108
ILE A 124
LEU A 136
 ACT  A1331 (-3.8A)
None
None
None
None
 1.13A 6b3bA-4axnA:
undetectable		 6b3bA-4axnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4axn CHITINASE C1
(Serratia
marcescens) 		5 / 10 LEU A 262
TYR A 323
GLY A 296
LEU A 236
TYR A 207
 None
 1.31A 6bsjA-4axnA:
undetectable		 6bsjA-4axnA:
13.31