SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4axs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 12 THR A 229
GLY A 187
ALA A   7
VAL A 227
LEU A 213
 SO4  A1312 (-3.4A)
None
None
None
None
 1.13A 1jg4A-4axsA:
3.0		 1jg4A-4axsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 190
GLY A  82
LEU A 109
GLY A  78
 None
 1.20A 1jhoA-4axsA:
2.3		 1jhoA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 190
GLY A  82
LEU A 109
GLY A  78
 None
 1.19A 1jhrA-4axsA:
undetectable		 1jhrA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 189
GLY A  82
LEU A 109
GLY A  78
 None
 1.29A 1jhyA-4axsA:
2.5		 1jhyA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 189
GLY A  82
LEU A 109
GLY A  78
 None
 1.28A 1l4nA-4axsA:
2.1		 1l4nA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 189
GLY A  82
LEU A 109
GLY A  78
 None
 1.29A 1l5kA-4axsA:
2.1		 1l5kA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 190
GLY A  82
LEU A 109
GLY A  78
 None
 1.21A 1l5kA-4axsA:
2.1		 1l5kA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 190
GLY A  82
LEU A 109
GLY A  78
 None
 1.19A 1l5lA-4axsA:
undetectable		 1l5lA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 189
GLY A  82
LEU A 109
GLY A  78
 None
 1.26A 1l5mA-4axsA:
undetectable		 1l5mA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 9 THR A 110
GLY A 190
GLY A  82
LEU A 109
GLY A  78
 None
 1.19A 1l5mA-4axsA:
undetectable		 1l5mA-4axsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 12 PHE A 121
ALA A 160
PRO A 192
THR A 112
ILE A 163
 None
 1.30A 1mx8A-4axsA:
undetectable		 1mx8A-4axsA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		3 / 3 VAL A 227
ALA A   7
HIS A  45
 None
 0.76A 1q23C-4axsA:
undetectable		 1q23C-4axsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		3 / 3 VAL A 227
ALA A   7
HIS A  45
 None
 0.74A 1q23H-4axsA:
undetectable		 1q23H-4axsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		6 / 12 HIS A  45
ALA A   7
GLY A 190
GLY A 186
LEU A 109
ILE A 191
 None
 1.16A 1x1aA-4axsA:
3.7		 1x1aA-4axsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 11 MET A  88
GLU A  22
GLY A  10
HIS A  45
LEU A   8
 None
None
SO4  A1311 (-3.0A)
None
None
 1.30A 3hm1B-4axsA:
undetectable		 3hm1B-4axsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		4 / 7 ALA A 274
PHE A 225
ALA A 217
ALA A 212
 None
 0.87A 4du2B-4axsA:
undetectable		 4du2B-4axsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 12 VAL A   5
ILE A 207
GLY A 187
GLY A 190
ILE A 184
 None
 0.95A 4iv0A-4axsA:
2.9		 4iv0A-4axsA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		5 / 12 VAL A   5
ILE A 207
GLY A 187
GLY A 190
ILE A 184
 None
 0.99A 4mwzB-4axsA:
2.9		 4mwzB-4axsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		4 / 5 VAL A  51
VAL A 128
GLY A 129
PHE A  73
 None
 0.87A 5d4nA-4axsA:
undetectable
5d4nC-4axsA:
undetectable		 5d4nA-4axsA:
14.16
5d4nC-4axsA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		3 / 3 GLY A   9
GLN A  50
LYS A 209
 SO4  A1312 ( 3.6A)
None
SO4  A1311 (-3.2A)
 0.94A 5imsB-4axsA:
2.6		 5imsB-4axsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4axs CARBAMATE KINASE
(Mycoplasma
penetrans) 		3 / 3 SER A  80
HIS A  45
TYR A 107
 None
 0.98A 5y2tA-4axsA:
undetectable		 5y2tA-4axsA:
undetectable