SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4axv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4axv MPAA
(Vibrio
campbellii) 		5 / 10 LEU A 174
ALA A 225
ASP A 224
GLY A  57
VAL A 208
 None
 1.12A 1d4yA-4axvA:
undetectable		 1d4yA-4axvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4axv MPAA
(Vibrio
campbellii) 		5 / 12 LEU A 146
LEU A 143
LEU A 140
ALA A 139
LEU A  28
 None
 0.96A 1s9pC-4axvA:
undetectable		 1s9pC-4axvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 4axv MPAA
(Vibrio
campbellii) 		5 / 11 GLU A  36
VAL A  35
ALA A  33
SER A  39
ASP A 233
 None
 1.34A 2c12B-4axvA:
undetectable		 2c12B-4axvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 4axv MPAA
(Vibrio
campbellii) 		5 / 10 GLU A  36
VAL A  35
ALA A  33
SER A  39
ASP A 233
 None
 1.33A 2c12D-4axvA:
undetectable		 2c12D-4axvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4axv MPAA
(Vibrio
campbellii) 		5 / 11 GLU A  36
VAL A  35
ALA A  33
SER A  39
ASP A 233
 None
 1.36A 2c12F-4axvA:
undetectable		 2c12F-4axvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4axv MPAA
(Vibrio
campbellii) 		5 / 12 SER A  59
THR A 207
ILE A  43
PHE A 155
HIS A 156
 None
None
None
None
ZN  A 301 (-3.2A)
 1.28A 2vdyB-4axvA:
undetectable		 2vdyB-4axvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4axv MPAA
(Vibrio
campbellii) 		5 / 11 LEU A 174
ALA A 225
ASP A 224
GLY A  57
VAL A 208
 None
 1.02A 3el1A-4axvA:
undetectable		 3el1A-4axvA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4axv MPAA
(Vibrio
campbellii) 		6 / 12 VAL A 153
LEU A 229
TYR A 188
VAL A 162
ALA A 171
LEU A 170
 None
 1.45A 3nt1A-4axvA:
undetectable		 3nt1A-4axvA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4axv MPAA
(Vibrio
campbellii) 		6 / 12 VAL A 153
LEU A 229
TYR A 188
VAL A 162
ALA A 171
LEU A 170
 None
 1.45A 3nt1B-4axvA:
undetectable		 3nt1B-4axvA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4axv MPAA
(Vibrio
campbellii) 		5 / 10 LEU A 174
ALA A 225
ASP A 224
GLY A  57
VAL A 208
 None
 1.01A 3oxwC-4axvA:
undetectable		 3oxwC-4axvA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 4axv MPAA
(Vibrio
campbellii) 		5 / 11 LEU A 174
ALA A 225
ASP A 224
GLY A  57
VAL A 208
 None
 1.00A 3oxxB-4axvA:
undetectable		 3oxxB-4axvA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4axv MPAA
(Vibrio
campbellii) 		4 / 5 ASP A 185
GLU A 189
TYR A 188
ASP A 163
 None
 1.29A 3w9tD-4axvA:
undetectable		 3w9tD-4axvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4axv MPAA
(Vibrio
campbellii) 		5 / 12 SER A  59
THR A 207
ILE A  43
PHE A 155
HIS A 156
 None
None
None
None
ZN  A 301 (-3.2A)
 1.31A 4c49A-4axvA:
undetectable		 4c49A-4axvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4axv MPAA
(Vibrio
campbellii) 		6 / 12 ILE A 182
ALA A  45
VAL A 153
LEU A  58
GLY A  57
THR A 218
 None
 1.39A 5igtA-4axvA:
undetectable		 5igtA-4axvA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4axv MPAA
(Vibrio
campbellii) 		6 / 12 VAL A 153
LEU A 229
TYR A 188
VAL A 162
ALA A 171
LEU A 170
 None
 1.45A 5jvzA-4axvA:
undetectable		 5jvzA-4axvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4axv MPAA
(Vibrio
campbellii) 		3 / 3 GLY A  20
THR A  87
PRO A  80
 None
 0.65A 5v5zA-4axvA:
undetectable		 5v5zA-4axvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4axv MPAA
(Vibrio
campbellii) 		3 / 3 GLY A 192
THR A 196
GLU A 200
 None
 0.66A 6b58A-4axvA:
undetectable		 6b58A-4axvA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4axv MPAA
(Vibrio
campbellii) 		4 / 5 THR A 102
THR A  47
HIS A  48
GLY A 128
 None
None
ZN  A 301 (-3.2A)
None
 1.10A 6gbnC-4axvA:
undetectable		 6gbnC-4axvA:
20.18