SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ay1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 TYR A  32
PHE A  63
GLY A 103
ASP A 213
TRP A 360
 NAG  A 401 (-3.9A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 401 (-3.7A)
 0.87A 1e9lA-4ay1A:
54.1		 1e9lA-4ay1A:
43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 ALA A 182
ILE A 145
GLY A 103
GLY A 102
ILE A 101
 None
NAG  A 402 (-4.7A)
NAG  A 401 (-3.5A)
None
None
 0.90A 1sdvA-4ay1A:
undetectable		 1sdvA-4ay1A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLY A 270
ALA A 327
LEU A 311
VAL A 324
HIS A 226
 None
 1.07A 1ukbA-4ay1A:
undetectable		 1ukbA-4ay1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 ILE A  66
LEU A  81
ILE A  97
ILE A  51
 None
 0.71A 1uwjA-4ay1A:
undetectable		 1uwjA-4ay1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		6 / 11 TYR A  32
PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 NAG  A 401 (-3.9A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.75A 2a3aA-4ay1A:
15.1		 2a3aA-4ay1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.53A 2a3aB-4ay1A:
42.9		 2a3aB-4ay1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.59A 2a3bB-4ay1A:
14.8		 2a3bB-4ay1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		7 / 12 TYR A  32
TRP A  36
PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 NAG  A 401 (-3.9A)
NAG  A 400 (-4.3A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.76A 2a3cA-4ay1A:
15.0		 2a3cA-4ay1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		6 / 12 TRP A  36
PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 NAG  A 400 (-4.3A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.60A 2a3cB-4ay1A:
43.0		 2a3cB-4ay1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		6 / 12 LEU A 158
PHE A 111
LEU A 162
LEU A 140
ILE A 101
ALA A 182
 None
 1.44A 2bxqA-4ay1A:
undetectable		 2bxqA-4ay1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 MET A 342
ILE A 359
PRO A 325
GLY A 270
 None
 1.13A 2pnjB-4ay1A:
undetectable		 2pnjB-4ay1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ALA A 182
SER A 211
PHE A 212
GLY A 265
SER A 143
 None
None
NAG  A 401 (-4.8A)
None
NAG  A 401 (-3.4A)
 1.34A 2vh3A-4ay1A:
undetectable		 2vh3A-4ay1A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 THR A  34
ASP A 363
SER A 361
TYR A 269
 None
None
None
NAG  A 400 (-3.7A)
 1.38A 2xz5A-4ay1A:
undetectable
2xz5C-4ay1A:
undetectable		 2xz5A-4ay1A:
20.22
2xz5C-4ay1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.29A 3fhjA-4ay1A:
undetectable		 3fhjA-4ay1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.36A 3fhjB-4ay1A:
undetectable		 3fhjB-4ay1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.32A 3fhjC-4ay1A:
undetectable		 3fhjC-4ay1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.26A 3fhjE-4ay1A:
undetectable		 3fhjE-4ay1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.29A 3fi0A-4ay1A:
undetectable		 3fi0A-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.30A 3fi0C-4ay1A:
undetectable		 3fi0C-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.24A 3fi0D-4ay1A:
undetectable		 3fi0D-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.21A 3fi0F-4ay1A:
undetectable		 3fi0F-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.29A 3fi0H-4ay1A:
undetectable		 3fi0H-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.21A 3fi0J-4ay1A:
undetectable		 3fi0J-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.31A 3fi0K-4ay1A:
undetectable		 3fi0K-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.28A 3fi0M-4ay1A:
undetectable		 3fi0M-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.29A 3fi0N-4ay1A:
undetectable		 3fi0N-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.28A 3fi0O-4ay1A:
undetectable		 3fi0O-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 7 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.33A 3fi0P-4ay1A:
undetectable		 3fi0P-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.19A 3fi0R-4ay1A:
undetectable		 3fi0R-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		6 / 11 TYR A  32
PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 NAG  A 401 (-3.9A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.80A 3g6mA-4ay1A:
43.2		 3g6mA-4ay1A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP A 363
SER A 361
LEU A  99
SER A  62
ILE A  73
 None
 1.38A 3ko0A-4ay1A:
undetectable
3ko0B-4ay1A:
undetectable
3ko0C-4ay1A:
undetectable
3ko0D-4ay1A:
undetectable		 3ko0A-4ay1A:
13.70
3ko0B-4ay1A:
13.70
3ko0C-4ay1A:
13.70
3ko0D-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU A  99
SER A  62
ILE A  73
ASP A 363
SER A 361
 None
 1.40A 3ko0C-4ay1A:
undetectable
3ko0D-4ay1A:
undetectable
3ko0E-4ay1A:
undetectable
3ko0F-4ay1A:
undetectable		 3ko0C-4ay1A:
13.70
3ko0D-4ay1A:
13.70
3ko0E-4ay1A:
13.70
3ko0F-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP A 363
SER A 361
LEU A  99
SER A  62
ILE A  73
 None
 1.34A 3ko0C-4ay1A:
undetectable
3ko0D-4ay1A:
undetectable
3ko0E-4ay1A:
undetectable
3ko0F-4ay1A:
undetectable		 3ko0C-4ay1A:
13.70
3ko0D-4ay1A:
13.70
3ko0E-4ay1A:
13.70
3ko0F-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU A  99
SER A  62
ILE A  73
ASP A 363
SER A 361
 None
 1.38A 3ko0E-4ay1A:
undetectable
3ko0F-4ay1A:
undetectable
3ko0G-4ay1A:
undetectable
3ko0H-4ay1A:
undetectable		 3ko0E-4ay1A:
13.70
3ko0F-4ay1A:
13.70
3ko0G-4ay1A:
13.70
3ko0H-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A  99
SER A  62
ILE A  73
ASP A 363
SER A 361
 None
 1.41A 3ko0G-4ay1A:
undetectable
3ko0H-4ay1A:
undetectable
3ko0I-4ay1A:
undetectable
3ko0J-4ay1A:
undetectable		 3ko0G-4ay1A:
13.70
3ko0H-4ay1A:
13.70
3ko0I-4ay1A:
13.70
3ko0J-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP A 363
SER A 361
LEU A  99
SER A  62
ILE A  73
 None
 1.40A 3ko0K-4ay1A:
undetectable
3ko0L-4ay1A:
undetectable
3ko0M-4ay1A:
undetectable
3ko0N-4ay1A:
undetectable		 3ko0K-4ay1A:
13.70
3ko0L-4ay1A:
13.70
3ko0M-4ay1A:
13.70
3ko0N-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU A  99
SER A  62
ILE A  73
ASP A 363
SER A 361
 None
 1.37A 3ko0O-4ay1A:
undetectable
3ko0P-4ay1A:
undetectable
3ko0Q-4ay1A:
undetectable
3ko0R-4ay1A:
undetectable		 3ko0O-4ay1A:
13.70
3ko0P-4ay1A:
13.70
3ko0Q-4ay1A:
13.70
3ko0R-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 ASP A 363
SER A 361
LEU A  99
SER A  62
ILE A  73
 None
 1.34A 3ko0O-4ay1A:
undetectable
3ko0P-4ay1A:
undetectable
3ko0Q-4ay1A:
undetectable
3ko0R-4ay1A:
undetectable		 3ko0O-4ay1A:
13.70
3ko0P-4ay1A:
13.70
3ko0Q-4ay1A:
13.70
3ko0R-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A 153
VAL A 157
GLU A 151
 None
 0.73A 3v4tA-4ay1A:
undetectable
3v4tD-4ay1A:
undetectable		 3v4tA-4ay1A:
21.15
3v4tD-4ay1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ALA A 357
GLY A 265
LEU A 354
LEU A 209
ASN A 208
 None
 1.12A 3wdmA-4ay1A:
undetectable		 3wdmA-4ay1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ALA A 357
GLY A 265
LEU A 354
LEU A 209
ASN A 208
 None
 1.13A 3wdmC-4ay1A:
undetectable		 3wdmC-4ay1A:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQV_A_GCSA501_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.40A 3wqvA-4ay1A:
51.4		 3wqvA-4ay1A:
35.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQW_A_GCSA501_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
 None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
 0.39A 3wqwA-4ay1A:
51.5		 3wqwA-4ay1A:
35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE A 131
LEU A 140
GLY A 139
PHE A 137
ALA A 182
 None
 1.29A 4eb4A-4ay1A:
undetectable		 4eb4A-4ay1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE A 131
LEU A 140
GLY A 139
PHE A 137
ALA A 182
 None
 1.28A 4eb4B-4ay1A:
undetectable		 4eb4B-4ay1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 PHE A 273
TRP A 333
PRO A 229
GLN A 322
 None
 1.00A 4j7uD-4ay1A:
2.2		 4j7uD-4ay1A:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 THR A  34
TRP A  36
ARG A  40
TRP A 360
 None
NAG  A 400 (-4.3A)
None
NAG  A 401 (-3.7A)
 0.75A 4nsbA-4ay1A:
53.6		 4nsbA-4ay1A:
49.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASN A  50
THR A 268
ARG A  40
PHE A  46
THR A 368
 None
 1.46A 4xt7A-4ay1A:
undetectable		 4xt7A-4ay1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 110
TYR A  61
LEU A  99
ILE A  85
PHE A 131
 None
 0.93A 5eskA-4ay1A:
undetectable		 5eskA-4ay1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 PHE A  63
GLY A 103
ASP A 213
TRP A 360
 None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 401 (-3.7A)
 0.49A 5gqbA-4ay1A:
43.1		 5gqbA-4ay1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 PRO A 147
TYR A 195
PHE A 111
SER A 100
 None
 1.13A 5l1fC-4ay1A:
3.3		 5l1fC-4ay1A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 VAL A 328
LEU A 275
THR A 274
ALA A 286
PRO A 285
 None
 1.33A 5tt3C-4ay1A:
undetectable		 5tt3C-4ay1A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.35A 5v0iA-4ay1A:
undetectable		 5v0iA-4ay1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.33A 5v0iB-4ay1A:
undetectable		 5v0iB-4ay1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A  98
ASP A 141
GLY A 183
GLY A 265
ILE A  60
 None
None
NAG  A 401 ( 4.8A)
None
None
 1.02A 6dh6B-4ay1A:
undetectable		 6dh6B-4ay1A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ILE A 266
ALA A 357
GLY A 356
LEU A 354
GLY A 388
 None
 1.32A 6nm4B-4ay1A:
undetectable		 6nm4B-4ay1A:
18.13