SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ay2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 VAL A 405
PHE A 371
VAL A 338
ILE A 344
PHE A 296
 None
 1.14A 1c9hA-4ay2A:
undetectable		 1c9hA-4ay2A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 GLU A 483
LEU A 552
GLY A 505
PHE A 504
ALA A 563
 None
 1.23A 1hvyA-4ay2A:
undetectable		 1hvyA-4ay2A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 GLU A 556
LEU A 639
ALA A 642
LEU A 643
 None
 0.90A 1hwiB-4ay2A:
undetectable		 1hwiB-4ay2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 GLU A 556
LEU A 639
ALA A 642
LEU A 643
 None
 0.89A 1hwiD-4ay2A:
undetectable		 1hwiD-4ay2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 GLU A 556
LEU A 639
ALA A 642
LEU A 643
 None
 0.90A 1hwiC-4ay2A:
undetectable		 1hwiC-4ay2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LEU A 496
CYH A 813
ALA A 815
CYH A 810
 None
ZN  A1923 (-2.1A)
ZN  A1923 ( 4.9A)
ZN  A1923 (-2.2A)
 0.90A 1mz9D-4ay2A:
undetectable		 1mz9D-4ay2A:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 ALA A 486
SER A 497
LEU A 496
VAL A 516
 None
 0.70A 2bxgA-4ay2A:
3.6		 2bxgA-4ay2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 SER A 411
THR A 441
PHE A 776
 None
 0.71A 2x91A-4ay2A:
3.0		 2x91A-4ay2A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 ALA A 558
ASP A 562
THR A 697
ILE A 660
ILE A 647
 None
 0.98A 3clbB-4ay2A:
undetectable		 3clbB-4ay2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 ILE A 862
PHE A 838
HIS A 871
 None
 0.67A 3h0aA-4ay2A:
undetectable		 3h0aA-4ay2A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 LEU A 614
ARG A 559
PRO A 658
GLY A 649
 None
 1.02A 3hcrA-4ay2A:
4.0		 3hcrA-4ay2A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 7 LEU A 614
ARG A 559
PRO A 658
GLY A 649
 None
 1.08A 3hcrB-4ay2A:
3.9		 3hcrB-4ay2A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 ILE A 647
ARG A 559
ILE A 631
THR A 630
VAL A 640
 None
 1.38A 3ijdB-4ay2A:
0.0		 3ijdB-4ay2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.85A 3ko0K-4ay2A:
undetectable
3ko0L-4ay2A:
undetectable
3ko0S-4ay2A:
undetectable
3ko0T-4ay2A:
undetectable		 3ko0K-4ay2A:
9.75
3ko0L-4ay2A:
9.75
3ko0S-4ay2A:
9.75
3ko0T-4ay2A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.89A 3ko0M-4ay2A:
undetectable
3ko0N-4ay2A:
undetectable
3ko0O-4ay2A:
undetectable
3ko0P-4ay2A:
undetectable		 3ko0M-4ay2A:
9.75
3ko0N-4ay2A:
9.75
3ko0O-4ay2A:
9.75
3ko0P-4ay2A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 PHE A 776
LEU A 434
ASP A 435
LEU A 430
ILE A 261
 None
 0.88A 3ko0M-4ay2A:
undetectable
3ko0N-4ay2A:
undetectable
3ko0O-4ay2A:
undetectable
3ko0P-4ay2A:
undetectable		 3ko0M-4ay2A:
9.75
3ko0N-4ay2A:
9.75
3ko0O-4ay2A:
9.75
3ko0P-4ay2A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 7 TYR A 390
VAL A 334
VAL A 294
ILE A 365
 None
 1.20A 3ms9B-4ay2A:
undetectable		 3ms9B-4ay2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 7 PHE A 853
VAL A 877
ILE A 875
TYR A 879
 None
 0.92A 3pglA-4ay2A:
undetectable		 3pglA-4ay2A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 ASP A 565
ARG A 559
LYS A 561
 None
 1.04A 3wipG-4ay2A:
undetectable		 3wipG-4ay2A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 ASP A 550
ARG A 546
ASP A 641
 None
 0.73A 4fp9C-4ay2A:
undetectable		 4fp9C-4ay2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 THR A 377
LEU A 434
VAL A 405
VAL A 294
 None
 1.04A 4l4bA-4ay2A:
undetectable		 4l4bA-4ay2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 7 SER A 891
ILE A 889
LEU A 808
PHE A 892
 None
 1.05A 4uymA-4ay2A:
undetectable		 4uymA-4ay2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 TYR A 473
LYS A 470
LEU A 597
GLU A 596
 None
 1.25A 4z4hA-4ay2A:
undetectable		 4z4hA-4ay2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 7 ILE A 277
LEU A 368
GLY A 257
LYS A 256
 None
 0.94A 4z69A-4ay2A:
3.0		 4z69A-4ay2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 11 GLY A 407
ALA A 436
ASN A 376
CYH A 374
VAL A 412
 None
 1.46A 5c8tB-4ay2A:
3.7		 5c8tB-4ay2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 GLY A 415
MET A 761
CYH A 263
THR A 409
LEU A 430
 None
 1.47A 5fhzD-4ay2A:
undetectable		 5fhzD-4ay2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 VAL A 405
PHE A 371
VAL A 338
ILE A 344
PHE A 296
 None
 1.16A 5hkgA-4ay2A:
undetectable		 5hkgA-4ay2A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 9 VAL A 293
ILE A 406
GLY A 407
LEU A 408
PHE A 314
 None
None
None
MG  A1925 ( 4.7A)
None
 0.96A 5vkqC-4ay2A:
3.9
5vkqD-4ay2A:
3.9		 5vkqC-4ay2A:
17.29
5vkqD-4ay2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 10 HIS A 444
ALA A 254
GLY A 407
ILE A 406
ALA A 251
 None
 1.32A 5vyhA-4ay2A:
undetectable		 5vyhA-4ay2A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.42A 6cbdA-4ay2A:
undetectable		 6cbdA-4ay2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 ILE A 262
ILE A 406
VAL A 273
ILE A 277
PHE A 295
 None
 1.12A 6hlpA-4ay2A:
2.1		 6hlpA-4ay2A:
19.97