SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ay7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.91A 1dfoA-4ay7A:
undetectable		 1dfoA-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.91A 1dfoB-4ay7A:
undetectable		 1dfoB-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.91A 1dfoC-4ay7A:
undetectable		 1dfoC-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.91A 1dfoD-4ay7A:
undetectable		 1dfoD-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.89A 1eqbA-4ay7A:
undetectable		 1eqbA-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.89A 1eqbB-4ay7A:
undetectable		 1eqbB-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.90A 1eqbC-4ay7A:
undetectable		 1eqbC-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  17
GLY A  19
LEU A  13
VAL A 145
SER A 261
 None
 0.89A 1eqbD-4ay7A:
undetectable		 1eqbD-4ay7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 LEU A 226
LEU A 239
THR A 237
ILE A 201
ILE A 187
 None
 1.17A 1i18A-4ay7A:
undetectable
1i18B-4ay7A:
undetectable		 1i18A-4ay7A:
15.17
1i18B-4ay7A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 ILE A 187
LEU A 226
LEU A 239
THR A 237
ILE A 201
 None
 1.17A 1i18A-4ay7A:
undetectable
1i18B-4ay7A:
undetectable		 1i18A-4ay7A:
15.17
1i18B-4ay7A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 11 ALA A 269
GLY A 277
GLY A 311
ASP A 313
ILE A 312
 None
None
None
MG  A 600 (-3.1A)
None
 1.16A 1pg2A-4ay7A:
undetectable		 1pg2A-4ay7A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		6 / 12 GLY A 197
ASP A 199
VAL A  72
GLY A 139
ALA A  57
ILE A 134
 None
 1.36A 1rl8A-4ay7A:
undetectable		 1rl8A-4ay7A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 LEU A  81
ALA A 185
ILE A 181
ASP A 157
LEU A 158
 None
 1.10A 1yi4A-4ay7A:
undetectable		 1yi4A-4ay7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 ALA A 182
ALA A 185
LEU A 118
LEU A  81
ALA A  84
 None
 0.65A 2bxeA-4ay7A:
undetectable		 2bxeA-4ay7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 ALA A 182
ALA A 185
LEU A 118
LEU A  81
ALA A  84
 None
 0.72A 2bxgB-4ay7A:
undetectable		 2bxgB-4ay7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		4 / 7 THR A  33
SER A  67
VAL A 334
LEU A  13
 None
 1.01A 2hdnE-4ay7A:
undetectable
2hdnF-4ay7A:
undetectable
2hdnH-4ay7A:
undetectable		 2hdnE-4ay7A:
10.45
2hdnF-4ay7A:
24.18
2hdnH-4ay7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		4 / 7 SER A  67
VAL A 334
LEU A  13
THR A  33
 None
 0.98A 2hdnF-4ay7A:
undetectable
2hdnG-4ay7A:
undetectable
2hdnH-4ay7A:
undetectable		 2hdnF-4ay7A:
24.18
2hdnG-4ay7A:
10.45
2hdnH-4ay7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 VAL A 262
LEU A 249
GLY A 310
ALA A 269
LEU A 282
 None
 1.03A 3pghC-4ay7A:
undetectable		 3pghC-4ay7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 ARG A 135
ALA A  71
VAL A 145
SER A 235
VAL A 238
 None
 1.27A 4da7A-4ay7A:
undetectable		 4da7A-4ay7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 TYR A 105
LEU A 158
ALA A  84
GLU A 184
ALA A 185
 None
 1.30A 4fiaA-4ay7A:
undetectable		 4fiaA-4ay7A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 TYR A 105
LEU A 158
ALA A  84
GLU A 184
ALA A 185
 None
 1.30A 4fiaA-4ay7A:
undetectable		 4fiaA-4ay7A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 11 ALA A 185
ALA A 190
VAL A 100
HIS A 103
LEU A 158
 None
 1.12A 4nqaA-4ay7A:
undetectable		 4nqaA-4ay7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 VAL A 262
LEU A 249
GLY A 310
ALA A 269
LEU A 282
 None
 1.07A 4ph9A-4ay7A:
undetectable		 4ph9A-4ay7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 10 VAL A 262
LEU A 249
GLY A 310
ALA A 269
LEU A 282
 None
 1.06A 4ph9B-4ay7A:
undetectable		 4ph9B-4ay7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 9 ALA A 196
ALA A 192
ALA A 190
SER A 235
ALA A 198
 None
 1.10A 4twdA-4ay7A:
undetectable
4twdB-4ay7A:
undetectable
4twdC-4ay7A:
undetectable
4twdD-4ay7A:
undetectable
4twdE-4ay7A:
undetectable		 4twdA-4ay7A:
22.16
4twdB-4ay7A:
22.16
4twdC-4ay7A:
22.16
4twdD-4ay7A:
22.16
4twdE-4ay7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 12 ASP A 173
GLU A 176
LEU A 158
ALA A 178
ARG A 225
 None
 1.31A 5nd4B-4ay7A:
3.7		 5nd4B-4ay7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		5 / 11 LEU A 315
GLU A 264
GLY A 318
LEU A 308
ALA A 304
 None
 1.10A 5o96A-4ay7A:
undetectable
5o96B-4ay7A:
undetectable		 5o96A-4ay7A:
21.71
5o96B-4ay7A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE
(Methanosarcina
mazei) 		3 / 3 SER A 163
LYS A 162
SER A 160
 None
 0.70A 6az3P-4ay7A:
undetectable		 6az3P-4ay7A:
15.62