SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ay9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 ILE X 132
THR X 159
ILE X 160
LEU X 177
ILE X 157
 None
 0.93A 1rx7A-4ay9X:
undetectable		 1rx7A-4ay9X:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		3 / 3 PHE X  53
PHE X  66
PHE X  69
 None
 0.66A 2od9A-4ay9X:
undetectable		 2od9A-4ay9X:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		3 / 3 PHE X  53
PHE X  66
PHE X  69
 None
 0.66A 2qqgA-4ay9X:
undetectable		 2qqgA-4ay9X:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		3 / 3 SER X 268
GLU X 197
ASP X 150
 None
 0.82A 2zulA-4ay9X:
undetectable		 2zulA-4ay9X:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 PHE X 190
GLY X 192
GLY X 167
LEU X 168
ASN X 163
 None
NAG  X1191 ( 4.1A)
None
None
NAG  X1191 (-3.4A)
 1.00A 3av6A-4ay9X:
undetectable		 3av6A-4ay9X:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 LEU X 177
ASN X 178
LEU X 200
LEU X 195
LEU X 148
 None
 1.29A 3d90B-4ay9X:
undetectable		 3d90B-4ay9X:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		3 / 3 SER X 268
GLU X 197
ASP X 150
 None
 0.76A 3dmhA-4ay9X:
undetectable		 3dmhA-4ay9X:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 6 LEU X 135
ASN X 180
SER X 164
PHE X 190
 None
 1.47A 3i9jB-4ay9X:
undetectable		 3i9jB-4ay9X:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 8 PHE X  91
ALA X  65
PHE X  66
THR X  56
 None
 0.87A 3t3sD-4ay9X:
undetectable		 3t3sD-4ay9X:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 11 THR X 130
ALA X 105
LEU X  83
PHE X 116
ILE X 100
 None
 1.33A 4claA-4ay9X:
undetectable		 4claA-4ay9X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 11 THR X 130
ALA X 105
PHE X 116
VAL X  90
ILE X 100
 None
 1.44A 4claA-4ay9X:
undetectable		 4claA-4ay9X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 6 LEU X 233
LEU X 209
ILE X 185
THR X 228
 None
 0.93A 4do3B-4ay9X:
undetectable		 4do3B-4ay9X:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		4 / 7 ILE X 160
PHE X 190
LEU X 177
THR X 228
 None
 1.04A 4mmcA-4ay9X:
undetectable		 4mmcA-4ay9X:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		3 / 3 ASP X 196
ASN X 240
PHE X 170
 None
 0.74A 5jglB-4ay9X:
undetectable		 5jglB-4ay9X:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 PHE X 214
LEU X 195
PRO X 220
ILE X 225
LEU X 261
 None
 1.18A 5ljcA-4ay9X:
undetectable		 5ljcA-4ay9X:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR
(Homo
sapiens) 		5 / 12 ILE X 132
THR X 159
ILE X 160
LEU X 177
ILE X 157
 None
 1.03A 7dfrA-4ay9X:
undetectable		 7dfrA-4ay9X:
17.33