SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ayc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ayc E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		4 / 7 TYR A 425
SER A 424
CYH A 423
ILE A 405
 None
None
ZN  A1485 (-2.3A)
ZN  A1485 (-4.8A)
 1.17A 2xz5A-4aycA:
undetectable
2xz5B-4aycA:
undetectable		 2xz5A-4aycA:
21.43
2xz5B-4aycA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4ayc E3 UBIQUITIN-PROTEIN
LIGASE RNF8
(Homo
sapiens) 		4 / 5 CYH A 437
ILE A 439
HIS A 420
LEU A 416
 ZN  A1484 (-2.3A)
ZN  A1484 ( 4.8A)
ZN  A1484 (-3.1A)
None
 1.41A 3qpkA-4aycA:
undetectable		 3qpkA-4aycA:
12.16