SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ayi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		5 / 12 GLY D 318
GLY D 219
ILE D 316
ALA D 221
GLN D 320
 None
 1.06A 1ri4A-4ayiD:
undetectable		 1ri4A-4ayiD:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		4 / 4 LEU D 133
LEU D  99
SER D 127
LEU D  89
 None
 1.18A 1ya3A-4ayiD:
undetectable		 1ya3A-4ayiD:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		4 / 5 PHE D 222
PHE D 143
SER D 114
PHE D 194
 None
 1.38A 2v0mD-4ayiD:
undetectable		 2v0mD-4ayiD:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		4 / 8 GLY D 201
GLY D 200
ILE D 163
THR D 130
 None
 0.65A 3d41A-4ayiD:
undetectable		 3d41A-4ayiD:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		5 / 11 GLY D 159
ILE D 176
GLU D 177
ASP D 142
GLN D 162
 None
 1.00A 3nmuB-4ayiD:
undetectable
3nmuJ-4ayiD:
undetectable		 3nmuB-4ayiD:
21.41
3nmuJ-4ayiD:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		5 / 12 LEU D 289
ALA D 303
ALA D 221
ALA D 173
VAL D 171
 None
 0.93A 4nkxC-4ayiD:
undetectable		 4nkxC-4ayiD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		5 / 12 LEU D 289
ALA D 303
ALA D 221
ALA D 173
VAL D 171
 None
 0.93A 4nkxD-4ayiD:
undetectable		 4nkxD-4ayiD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		4 / 7 ALA D  84
ILE D 163
LEU D 113
PHE D 141
 None
 1.06A 4uymB-4ayiD:
undetectable		 4uymB-4ayiD:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		5 / 12 LEU D 111
ILE D 105
GLY D 109
THR D 153
LEU D 113
 None
 1.24A 5nfjC-4ayiD:
undetectable		 5nfjC-4ayiD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4ayi LIPOPROTEIN GNA1870
CCOMPND 7
(Neisseria
meningitidis) 		4 / 8 LEU D 274
LEU D 289
ALA D 290
LEU D 199
 None
 0.87A 5y7pE-4ayiD:
undetectable		 5y7pE-4ayiD:
24.07