SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ayj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 7 MET A  29
PHE A  28
SER A  23
PHE A  92
 None
 1.14A 1fxvA-4ayjA:
undetectable
1fxvB-4ayjA:
undetectable		 1fxvA-4ayjA:
22.31
1fxvB-4ayjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 7 LEU A 167
THR A 163
GLY A 160
LEU A   6
 None
 0.95A 1gtiA-4ayjA:
undetectable		 1gtiA-4ayjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 5 PHE A  92
LEU A 208
PHE A  28
SER A 102
 None
 1.28A 1wrlC-4ayjA:
undetectable		 1wrlC-4ayjA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 6 PHE A  28
ILE A 108
PHE A  94
GLY A 161
GLY A 160
 None
 1.17A 2qx6A-4ayjA:
undetectable
2qx6B-4ayjA:
undetectable		 2qx6A-4ayjA:
20.23
2qx6B-4ayjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 12 PRO A 204
LEU A 118
GLY A 160
GLY A 161
PRO A 110
 None
 0.97A 3axzA-4ayjA:
undetectable		 3axzA-4ayjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		3 / 3 HIS A 122
SER A 159
ASN A 196
 GAL  A1233 (-3.5A)
None
None
 0.88A 3s8pB-4ayjA:
undetectable		 3s8pB-4ayjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 5 PHE A  94
LEU A 118
GLY A 161
ILE A   5
 None
 0.87A 3wrkA-4ayjA:
undetectable		 3wrkA-4ayjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 9 GLY A 160
PHE A  92
SER A 114
GLY A 116
TYR A  90
 None
 1.24A 3ztvA-4ayjA:
undetectable		 3ztvA-4ayjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 5 PHE A  94
PHE A  28
ILE A   5
GLY A   4
 None
 0.85A 4ejjC-4ayjA:
undetectable		 4ejjC-4ayjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 9 GLY A 161
GLY A 160
PHE A  28
ILE A 108
PHE A  94
 None
 1.24A 4fgjA-4ayjA:
1.6
4fgjB-4ayjA:
undetectable		 4fgjA-4ayjA:
19.47
4fgjB-4ayjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 12 CYH A 170
GLY A 160
LEU A  84
PHE A  77
GLY A 157
 None
 0.95A 4n09C-4ayjA:
undetectable		 4n09C-4ayjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		3 / 3 LYS A  72
ASN A  95
ASP A  68
 None
 0.80A 4o1eA-4ayjA:
undetectable		 4o1eA-4ayjA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		3 / 3 THR A  70
ASN A 196
PHE A 199
 None
 0.83A 4pd9A-4ayjA:
undetectable		 4pd9A-4ayjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 6 GLY A 160
PHE A  94
ILE A   5
PHE A 100
 None
 1.06A 4qogA-4ayjA:
undetectable
4qogB-4ayjA:
undetectable		 4qogA-4ayjA:
20.23
4qogB-4ayjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 12 PRO A 204
LEU A 118
GLY A 160
GLY A 161
PRO A 110
 None
 0.98A 4yvgA-4ayjA:
undetectable		 4yvgA-4ayjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 7 PHE A 100
PHE A  94
THR A 120
LEU A 118
 None
 0.93A 4zdzA-4ayjA:
undetectable		 4zdzA-4ayjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 12 GLY A 161
GLY A 160
PHE A  28
ILE A 108
PHE A  94
 None
 1.17A 4zvmA-4ayjA:
undetectable
4zvmB-4ayjA:
undetectable		 4zvmA-4ayjA:
20.23
4zvmB-4ayjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		3 / 3 HIS A 122
SER A 159
ASN A 196
 GAL  A1233 (-3.5A)
None
None
 0.86A 5cprB-4ayjA:
undetectable		 5cprB-4ayjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 8 PHE A 100
PHE A  94
THR A 120
LEU A 118
 None
 0.92A 5esfA-4ayjA:
undetectable		 5esfA-4ayjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 7 PHE A 100
PHE A  94
THR A 120
LEU A 118
 None
 0.95A 5esmA-4ayjA:
undetectable		 5esmA-4ayjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 8 PHE A 100
PHE A  94
THR A 120
LEU A 118
 None
 0.87A 5hs1A-4ayjA:
undetectable		 5hs1A-4ayjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		4 / 5 PHE A  94
LEU A 118
GLY A 161
ILE A   5
 None
 0.85A 5ik1A-4ayjA:
undetectable		 5ik1A-4ayjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 12 PHE A  28
ILE A 226
SER A 102
PHE A  94
GLY A 160
 None
 1.07A 5m24A-4ayjA:
undetectable		 5m24A-4ayjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 12 PRO A 204
LEU A 118
GLY A 160
GLY A 161
PRO A 110
 None
 0.92A 5wyqA-4ayjA:
undetectable		 5wyqA-4ayjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE
(Bacteroides
ovatus) 		5 / 12 PRO A 204
LEU A 118
GLY A 160
GLY A 161
PRO A 110
 None
 0.95A 5wyqB-4ayjA:
undetectable		 5wyqB-4ayjA:
21.03