SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ays'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 10 VAL A 116
TYR A  90
LEU A 122
LEU A 121
VAL A 104
 None
 1.21A 1cqpA-4aysA:
undetectable
1cqpB-4aysA:
undetectable		 1cqpA-4aysA:
12.69
1cqpB-4aysA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 6 LEU A  68
THR A 306
ALA A 310
LEU A  71
 None
 1.27A 1etb2-4aysA:
undetectable		 1etb2-4aysA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 GLY A 324
PRO A 323
ASP A 398
ALA A 367
 None
 0.95A 1gxsA-4aysA:
undetectable
1gxsB-4aysA:
undetectable		 1gxsA-4aysA:
17.00
1gxsB-4aysA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 523
VAL A 464
LEU A 468
LEU A 496
LEU A 452
 None
 1.19A 1mx1C-4aysA:
undetectable		 1mx1C-4aysA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 PRO A  65
ILE A 262
GLY A 269
VAL A 272
ALA A 312
 None
 1.05A 1nv8A-4aysA:
undetectable		 1nv8A-4aysA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 594
ALA A 476
LEU A 632
GLY A 480
LEU A 638
 None
 1.14A 1qabF-4aysA:
undetectable		 1qabF-4aysA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 PRO A  65
ILE A 262
GLY A 269
VAL A 272
ALA A 312
 None
 1.06A 1sg9C-4aysA:
undetectable		 1sg9C-4aysA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 9 TYR A 258
LEU A 281
VAL A 254
ALA A 253
LEU A  49
 None
 1.28A 1tbfA-4aysA:
undetectable		 1tbfA-4aysA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 LEU A 114
GLY A 115
LEU A 547
PRO A 485
 None
 0.92A 1ya4A-4aysA:
undetectable		 1ya4A-4aysA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 LEU A 578
LEU A 577
ARG A 359
SER A 358
 None
 1.11A 2hc4A-4aysA:
undetectable		 2hc4A-4aysA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 490
MET A 543
GLY A 546
LEU A 547
LEU A 550
 None
 0.97A 2hw2A-4aysA:
undetectable		 2hw2A-4aysA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 TYR A 417
TRP A 392
ARG A 440
HIS A 409
 None
 1.42A 2vxaA-4aysA:
undetectable
2vxaC-4aysA:
undetectable
2vxaE-4aysA:
undetectable		 2vxaA-4aysA:
8.18
2vxaC-4aysA:
8.18
2vxaE-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 440
TYR A 417
TRP A 392
HIS A 409
 None
 1.46A 2vxaA-4aysA:
undetectable
2vxaB-4aysA:
undetectable
2vxaK-4aysA:
undetectable		 2vxaA-4aysA:
8.18
2vxaB-4aysA:
8.18
2vxaK-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 440
TYR A 417
TRP A 392
HIS A 409
 None
 1.44A 2vxaB-4aysA:
undetectable
2vxaC-4aysA:
undetectable
2vxaG-4aysA:
undetectable		 2vxaB-4aysA:
8.18
2vxaC-4aysA:
8.18
2vxaG-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 TYR A 417
TRP A 392
ARG A 440
HIS A 409
 None
 1.44A 2vxaD-4aysA:
undetectable
2vxaF-4aysA:
undetectable
2vxaI-4aysA:
undetectable		 2vxaD-4aysA:
8.18
2vxaF-4aysA:
8.18
2vxaI-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 440
TYR A 417
TRP A 392
HIS A 409
 None
 1.46A 2vxaD-4aysA:
undetectable
2vxaE-4aysA:
undetectable
2vxaL-4aysA:
undetectable		 2vxaD-4aysA:
8.18
2vxaE-4aysA:
8.18
2vxaL-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 HIS A 409
ARG A 440
TYR A 417
TRP A 392
 None
 1.44A 2vxaB-4aysA:
undetectable
2vxaG-4aysA:
undetectable
2vxaH-4aysA:
undetectable		 2vxaB-4aysA:
8.18
2vxaG-4aysA:
8.18
2vxaH-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 440
TYR A 417
TRP A 392
HIS A 409
 None
 1.44A 2vxaH-4aysA:
undetectable
2vxaI-4aysA:
undetectable
2vxaJ-4aysA:
undetectable		 2vxaH-4aysA:
8.18
2vxaI-4aysA:
8.18
2vxaJ-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 HIS A 409
TYR A 417
TRP A 392
ARG A 440
 None
 1.45A 2vxaD-4aysA:
undetectable
2vxaJ-4aysA:
undetectable
2vxaL-4aysA:
undetectable		 2vxaD-4aysA:
8.18
2vxaJ-4aysA:
8.18
2vxaL-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 HIS A 409
ARG A 440
TYR A 417
TRP A 392
 None
 1.43A 2vxaH-4aysA:
undetectable
2vxaJ-4aysA:
undetectable
2vxaK-4aysA:
undetectable		 2vxaH-4aysA:
8.18
2vxaJ-4aysA:
8.18
2vxaK-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 HIS A 409
ARG A 440
TYR A 417
TRP A 392
 None
 1.47A 2vxaA-4aysA:
undetectable
2vxaK-4aysA:
undetectable
2vxaL-4aysA:
undetectable		 2vxaA-4aysA:
8.18
2vxaK-4aysA:
8.18
2vxaL-4aysA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 8 TYR A 258
LEU A 281
LEU A 174
ALA A 277
 None
 1.08A 2wekA-4aysA:
undetectable		 2wekA-4aysA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 ARG A 636
GLU A 633
SER A 571
 None
 0.89A 2xctD-4aysA:
undetectable		 2xctD-4aysA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 4 LEU A 496
ARG A 470
LEU A 471
ALA A 455
 None
 0.97A 3b9mA-4aysA:
1.9		 3b9mA-4aysA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 PRO A 558
THR A 557
LEU A 588
 None
 0.72A 3ttrA-4aysA:
undetectable		 3ttrA-4aysA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 5 GLU A 112
GLY A 113
TYR A 110
GLN A 528
 None
 1.37A 3w9tD-4aysA:
undetectable		 3w9tD-4aysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 5 GLU A 112
GLY A 113
TYR A 110
GLN A 528
 None
 1.38A 3w9tE-4aysA:
undetectable		 3w9tE-4aysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 5 GLU A 112
GLY A 113
TYR A 110
GLN A 528
 None
 1.34A 3w9tG-4aysA:
undetectable		 3w9tG-4aysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 108
ALA A  92
VAL A 116
LEU A 161
GLY A 490
 None
 0.92A 4dc3A-4aysA:
undetectable		 4dc3A-4aysA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 TYR A 635
ARG A 359
SER A 595
 None
 1.03A 4dr2I-4aysA:
undetectable
4dr2J-4aysA:
0.6		 4dr2I-4aysA:
12.26
4dr2J-4aysA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 TYR A 635
ARG A 359
SER A 595
 None
 1.07A 4lf7I-4aysA:
undetectable
4lf7J-4aysA:
undetectable		 4lf7I-4aysA:
12.26
4lf7J-4aysA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 TYR A 635
ARG A 359
SER A 595
 None
 1.07A 4lf8I-4aysA:
undetectable
4lf8J-4aysA:
undetectable		 4lf8I-4aysA:
12.26
4lf8J-4aysA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 THR A 379
GLY A 482
ARG A 554
ALA A 562
 None
 0.92A 4txnA-4aysA:
undetectable		 4txnA-4aysA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 THR A 379
GLY A 482
ARG A 554
ALA A 562
 None
 0.92A 4txnB-4aysA:
undetectable		 4txnB-4aysA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 GLU A 492
GLY A 490
PHE A 544
GLN A 528
LEU A 111
 None
 1.06A 4uilH-4aysA:
undetectable
4uilL-4aysA:
undetectable		 4uilH-4aysA:
17.00
4uilL-4aysA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 ASN A 248
PHE A 198
TRP A 237
PHE A 226
 None
 1.39A 4v32C-4aysA:
undetectable		 4v32C-4aysA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 5 ARG A  24
ARG A  29
GLY A  31
GLU A  33
 None
 1.26A 4z3oA-4aysA:
undetectable
4z3oB-4aysA:
undetectable		 4z3oA-4aysA:
23.66
4z3oB-4aysA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 LEU A 452
ALA A 494
LEU A 468
LEU A 456
 None
 0.67A 4z90F-4aysA:
undetectable
4z90G-4aysA:
undetectable
4z90H-4aysA:
undetectable
4z90J-4aysA:
undetectable		 4z90F-4aysA:
18.88
4z90G-4aysA:
18.88
4z90H-4aysA:
18.88
4z90J-4aysA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 ASP A  95
ARG A  96
TYR A  93
 None
 1.01A 5a7mA-4aysA:
3.2		 5a7mA-4aysA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 ASP A  95
ARG A  96
TYR A  93
 None
 1.02A 5a7mB-4aysA:
3.4		 5a7mB-4aysA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 12 ARG A 274
ASP A 276
GLU A 318
HIS A 387
ASP A 388
 None
 0.85A 5csyB-4aysA:
13.8		 5csyB-4aysA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		5 / 11 ALA A 637
ALA A 476
LEU A 550
HIS A 549
VAL A 553
 None
 1.32A 5eb5A-4aysA:
undetectable		 5eb5A-4aysA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		3 / 3 MET A 543
HIS A 475
GLY A 490
 None
 0.66A 5gwzB-4aysA:
undetectable		 5gwzB-4aysA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 PHE A 481
GLY A 483
GLY A 381
HIS A 345
 None
 1.05A 5n9xA-4aysA:
undetectable		 5n9xA-4aysA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 7 ILE A 166
LEU A 108
LEU A 157
LEU A 168
 None
 0.72A 6g9bA-4aysA:
undetectable
6g9bB-4aysA:
undetectable		 6g9bA-4aysA:
8.97
6g9bB-4aysA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 5 ARG A 401
ALA A 400
GLN A 351
ILE A 394
 None
 1.39A 6g9bA-4aysA:
undetectable
6g9bB-4aysA:
undetectable		 6g9bA-4aysA:
8.97
6g9bB-4aysA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ays AMYLOSUCRASE
(Deinococcus
radiodurans) 		4 / 5 LEU A 579
TYR A 592
ILE A 390
GLY A 480
 None
 0.91A 6hd6A-4aysA:
undetectable		 6hd6A-4aysA:
9.37