SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ayx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 LEU A 579
ALA A 647
ALA A 643
VAL A 627
TYR A 590
 None
 1.35A 1kt4A-4ayxA:
undetectable		 1kt4A-4ayxA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		4 / 7 GLY A 530
THR A 535
ILE A 509
GLY A 532
 ACP  A 900 (-3.5A)
ACP  A 900 (-3.9A)
ACP  A 900 (-4.8A)
ACP  A 900 (-3.5A)
 0.87A 1usqA-4ayxA:
undetectable		 1usqA-4ayxA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 TYR A 544
SER A 531
ILE A 509
VAL A 536
LEU A 704
 None
ACP  A 900 (-3.9A)
ACP  A 900 (-4.8A)
None
None
 1.44A 1z9hA-4ayxA:
4.7		 1z9hA-4ayxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 TYR A 544
SER A 531
ILE A 509
VAL A 536
LEU A 704
 None
ACP  A 900 (-3.9A)
ACP  A 900 (-4.8A)
None
None
 1.44A 1z9hB-4ayxA:
undetectable		 1z9hB-4ayxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 TYR A 544
SER A 531
ILE A 509
VAL A 536
LEU A 704
 None
ACP  A 900 (-3.9A)
ACP  A 900 (-4.8A)
None
None
 1.44A 1z9hC-4ayxA:
4.7		 1z9hC-4ayxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 THR A 535
ILE A 688
SER A 531
VAL A 536
LEU A 704
 ACP  A 900 (-3.9A)
None
ACP  A 900 (-3.9A)
None
None
 1.13A 1z9hD-4ayxA:
4.7		 1z9hD-4ayxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 LEU A 314
MET A 436
LEU A 435
ILE A 196
GLY A 193
 None
 1.14A 2j7xA-4ayxA:
undetectable		 2j7xA-4ayxA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		4 / 6 VAL A 233
GLN A 241
GLY A 283
LEU A 163
 None
 1.01A 3bjwE-4ayxA:
undetectable		 3bjwE-4ayxA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 10 ALA A 461
ARG A 464
GLY A 463
LEU A 160
LEU A 282
 None
 1.06A 3wdmB-4ayxA:
undetectable		 3wdmB-4ayxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 10 ALA A 461
ARG A 464
GLY A 463
LEU A 160
LEU A 282
 None
 1.14A 3wdmD-4ayxA:
undetectable		 3wdmD-4ayxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		4 / 6 ARG A 617
GLY A 622
ALA A 600
GLN A 638
 None
 1.11A 4g0uA-4ayxA:
4.1		 4g0uA-4ayxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 LEU A 314
MET A 436
LEU A 435
ILE A 196
GLY A 193
 None
 1.14A 4j26A-4ayxA:
undetectable		 4j26A-4ayxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		3 / 4 SER A 449
GLY A 333
GLU A 391
 None
 0.46A 4juoA-4ayxA:
3.3
4juoC-4ayxA:
undetectable		 4juoA-4ayxA:
22.50
4juoC-4ayxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		4 / 6 GLY A 527
ILE A 509
ILE A 709
LEU A 686
 None
ACP  A 900 (-4.8A)
None
None
 0.78A 4o8fB-4ayxA:
1.4		 4o8fB-4ayxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 ILE A 443
VAL A 441
GLY A 447
SER A 444
VAL A 330
 None
 1.08A 5ergB-4ayxA:
undetectable		 5ergB-4ayxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		5 / 12 LEU A 314
MET A 436
LEU A 435
ILE A 196
GLY A 193
 None
 1.15A 5gs4A-4ayxA:
3.1		 5gs4A-4ayxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens) 		3 / 3 LYS A 457
LEU A 281
ARG A 284
 None
 0.85A 5yw0A-4ayxA:
undetectable		 5yw0A-4ayxA:
19.77