SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ayz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 10 TYR A 179
THR A  90
THR A  86
ALA A  87
TYR A  43
 None
 1.20A 2coiA-4ayzA:
undetectable
2coiB-4ayzA:
undetectable		 2coiA-4ayzA:
20.51
2coiB-4ayzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 10 TYR A  43
TYR A 179
THR A  90
THR A  86
ALA A  87
 None
 1.24A 2coiA-4ayzA:
undetectable
2coiB-4ayzA:
undetectable		 2coiA-4ayzA:
20.51
2coiB-4ayzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 TYR A 179
THR A  90
THR A  86
ALA A  87
TYR A  43
 None
 1.20A 2cojA-4ayzA:
undetectable
2cojB-4ayzA:
undetectable		 2cojA-4ayzA:
20.51
2cojB-4ayzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_A_ACTA511_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		4 / 4 ASN A 189
PHE A 142
SER A 141
GLN A 154
 None
 1.38A 3v5vA-4ayzA:
0.0		 3v5vA-4ayzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 ASN A  70
GLY A  65
ALA A 177
GLY A 178
GLU A 191
 None
 1.14A 4a6nA-4ayzA:
undetectable		 4a6nA-4ayzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 THR A  51
GLY A  65
THR A  64
ALA A  61
ASP A  57
 None
 1.50A 4qvnH-4ayzA:
undetectable
4qvnI-4ayzA:
undetectable		 4qvnH-4ayzA:
21.34
4qvnI-4ayzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 10 THR A  51
GLY A  65
THR A  64
ALA A  61
ASP A  57
 None
 1.49A 4qvnV-4ayzA:
undetectable
4qvnW-4ayzA:
undetectable		 4qvnV-4ayzA:
21.34
4qvnW-4ayzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 THR A  51
GLY A  65
THR A  64
ALA A  61
ASP A  57
 None
 1.50A 4qvqH-4ayzA:
undetectable
4qvqI-4ayzA:
undetectable		 4qvqH-4ayzA:
21.34
4qvqI-4ayzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 THR A  51
GLY A  65
THR A  64
ALA A  61
ASP A  57
 None
 1.50A 4qvqV-4ayzA:
undetectable
4qvqW-4ayzA:
undetectable		 4qvqV-4ayzA:
21.34
4qvqW-4ayzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 THR A  51
GLY A  65
THR A  64
ALA A  61
ASP A  57
 None
 1.49A 4qwuH-4ayzA:
undetectable
4qwuI-4ayzA:
undetectable		 4qwuH-4ayzA:
21.34
4qwuI-4ayzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 THR A  51
GLY A  65
THR A  64
ALA A  61
ASP A  57
 None
 1.50A 4qwuV-4ayzA:
undetectable
4qwuW-4ayzA:
undetectable		 4qwuV-4ayzA:
21.34
4qwuW-4ayzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		4 / 6 SER A 108
LEU A 109
TYR A  72
LEU A  69
 None
 1.02A 4wozA-4ayzA:
undetectable
4wozB-4ayzA:
undetectable		 4wozA-4ayzA:
21.85
4wozB-4ayzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens) 		4 / 6 ASP A  57
THR A 106
THR A  51
VAL A  53
 None
 1.15A 4yoaA-4ayzA:
undetectable		 4yoaA-4ayzA:
18.32