SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4az1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 5 ARG A 232
ALA A 130
LYS A 129
GLU A 124
 FMT  A1302 (-3.8A)
None
FMT  A1304 (-3.2A)
None
 0.88A 1e7cA-4az1A:
undetectable		 1e7cA-4az1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 7 TYR A  75
VAL A 223
GLU A 110
LEU A 151
 None
 0.93A 1j96B-4az1A:
undetectable		 1j96B-4az1A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		5 / 11 TYR A  75
VAL A 223
GLU A 110
LEU A 151
LEU A 176
 None
 1.13A 1mrqA-4az1A:
undetectable		 1mrqA-4az1A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 ASN A  49
ASN A  78
ARG A 267
 None
 0.88A 2rlcA-4az1A:
undetectable		 2rlcA-4az1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 8 SER A 205
TYR A 191
LEU A 122
THR A 211
 None
None
FMT  A1305 (-3.7A)
None
 1.10A 2v0zO-4az1A:
undetectable		 2v0zO-4az1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 5 GLY A 141
GLU A 155
GLY A 139
PRO A 135
 None
 1.01A 3onnA-4az1A:
undetectable		 3onnA-4az1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 8 ALA A  56
ASN A  80
ALA A  92
THR A 233
 None
 1.11A 3t3sE-4az1A:
undetectable		 3t3sE-4az1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 6 GLN A 188
PHE A 104
PRO A  96
LEU A 105
 None
FMT  A1306 ( 4.8A)
FMT  A1306 (-3.8A)
None
 1.26A 3tgvD-4az1A:
undetectable		 3tgvD-4az1A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		5 / 9 TYR A  75
VAL A 223
GLU A 110
LEU A 151
LEU A 176
 None
 1.08A 4l1xB-4az1A:
undetectable		 4l1xB-4az1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		5 / 9 TYR A  75
VAL A 223
ILE A 113
LEU A 151
LEU A 176
 None
 1.39A 4l1xB-4az1A:
undetectable		 4l1xB-4az1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 275
GLN A  22
ILE A 280
VAL A 271
VAL A 260
 None
 1.04A 5dpdA-4az1A:
undetectable		 5dpdA-4az1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 198
ILE A 199
ILE A 237
ALA A 239
LEU A 210
 None
EDO  A1301 ( 4.5A)
None
None
None
 0.97A 5e72A-4az1A:
undetectable		 5e72A-4az1A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		5 / 12 ASP A  33
THR A  60
PHE A 268
THR A  41
SER A  36
 None
 1.42A 5hfjC-4az1A:
undetectable		 5hfjC-4az1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 5 ASP A  67
THR A  73
GLN A  64
GLU A 110
 None
 1.27A 5k9dA-4az1A:
undetectable		 5k9dA-4az1A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 176
PHE A 186
LEU A 108
PHE A 104
 None
None
None
FMT  A1306 ( 4.8A)
 1.03A 5x19C-4az1A:
undetectable
5x19J-4az1A:
undetectable		 5x19C-4az1A:
19.87
5x19J-4az1A:
11.90